{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n HCG15 is a long non‐coding RNA that has emerged as an important regulator in the context of hypoxic stress. In hepatocellular carcinoma cells, HCG15 is transcriptionally induced by hypoxia via HIF‐1α, and its upregulation promotes tumor progression by enhancing cell migration, invasion, and proliferation. Mechanistically, HCG15 interacts with the transcription factor USF1 to facilitate USF1‐mediated transcription of ZNF641, thereby contributing to the aggressive phenotype of liver cancer cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In another pathological setting, HCG15 was found to be highly expressed in exosomes secreted by cardiomyocytes under hypoxic conditions. This exosomal HCG15 contributes to myocardial injury by promoting cardiomyocyte apoptosis, enhancing the production of inflammatory cytokines, and inhibiting cell proliferation through activation of the NF‐κB/p65 and p38 signaling pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Additionally, although changes in HCG15 expression have been observed in ovarian cancer cells following treatment with therapeutic agents such as ivermectin, its precise mechanistic contribution in this context remains to be fully elucidated."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings highlight HCG15 as a stress‐responsive lncRNA that modulates critical cellular processes—ranging from tumor cell aggressiveness under hypoxic conditions to the exacerbation of hypoxia‐induced cardiac injury—underscoring its potential as both a prognostic biomarker and a therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Honglin Yan, Na He, Shuixiang He "}, {"type": "b", "children": [{"type": "t", "text": "HCG15 is a hypoxia-responsive lncRNA and facilitates hepatocellular carcinoma cell proliferation and invasion by enhancing ZNF641 transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2022.03.143"}], "href": "https://doi.org/10.1016/j.bbrc.2022.03.143"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35427894"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35427894"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Beiyou Lin, Xi Chen, Chuanghong Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of exosomal LncRNA HCG15 prevents acute myocardial ischemic injury through the NF-κB/p65 and p38 pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-021-04281-8"}], "href": "https://doi.org/10.1038/s41419-021-04281-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34707098"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34707098"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Na Li, Xianquan Zhan "}, {"type": "b", "children": [{"type": "t", "text": "Anti-parasite drug ivermectin can suppress ovarian cancer by regulating lncRNA-EIF4A3-mRNA axes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EPMA J (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13167-020-00209-y"}], "href": "https://doi.org/10.1007/s13167-020-00209-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32549918"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32549918"}]}]}]}