{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Human chorionic gonadotropin (hCG) and its gene variants—including transcripts such as HCG16—play multifaceted roles in human physiology. In the reproductive axis, hCG‐related factors are essential for normal corpus luteum formation and the ovulatory process; deficiencies in key regulatory peptides can lead to impaired luteal development, underscoring the critical endocrine support required for fertility."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In the context of gestational trophoblastic disease, quantitative assays for hCG remain a cornerstone for diagnosis and monitoring, with declining hCG levels serving as a benchmark for complete remission in trophoblastic neoplasia."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its classical endocrine functions, hCG has been demonstrated to exert neuroprotective effects. Preclinical studies in neonatal models of hypoxic–ischemic injury showed that administration of hCG prior to the insult can significantly reduce tissue loss in vulnerable brain regions—possibly via dampening NMDA receptor–mediated excitotoxicity—thereby safeguarding the developing brain."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, recent genomic network analyses in malignancies such as colorectal cancer have identified dysregulated long non‐coding RNAs as part of complex competitive endogenous RNA pathways. In these studies, transcripts like HCG16 have emerged as potential biomarkers and regulatory players in oncogenic circuits."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies illustrate that hCG and its related gene variants, including HCG16, are not only pivotal for reproductive and luteal function but also contribute to neuroprotection and may be involved in tumorigenic regulatory networks.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Joseph A Cacioppo, Sang Wook Oh, Hey-young Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of function of endothelin-2 leads to reduced ovulation and CL formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0096115"}], "href": "https://doi.org/10.1371/journal.pone.0096115"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24763822"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24763822"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Y Tomoda, Y Asai, Y Arii, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Criteria of complete remission from trophoblastic neoplasia with the use of human chorionic gonadotropin (HCG) excretion pattern as a parameter."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer (1977)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1097-0142(197709)40:3"}, {"type": "a", "children": [{"type": "t", "text": "1016::aid-cncr2820400309"}], "href": "1016::aid-cncr2820400309"}, {"type": "t", "text": "3.0.co;2-s"}], "href": "https://doi.org/10.1002/1097-0142(197709"}, {"type": "t", "text": "40:3"}, {"type": "a", "children": [{"type": "t", "text": "1016::aid-cncr2820400309"}], "href": "1016::aid-cncr2820400309"}, {"type": "t", "text": "3.0.co;2-s) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "198083"}], "href": "https://pubmed.ncbi.nlm.nih.gov/198083"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Tammy Z Movsas, Rebecca L Weiner, M Banks Greenberg, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pretreatment with Human Chorionic Gonadotropin Protects the Neonatal Brain against the Effects of Hypoxic-Ischemic Injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Pediatr (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fped.2017.00232"}], "href": "https://doi.org/10.3389/fped.2017.00232"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29164084"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29164084"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Tao Meng, Zhangzhang Lan, Xiaoling Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive bioinformatics analysis of functional molecules in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gastrointest Oncol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.21037/jgo-21-921"}], "href": "https://doi.org/10.21037/jgo-21-921"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35284121"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35284121"}]}]}]}