{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Numerous large‐scale studies have highlighted the importance of long non‐coding RNAs (lncRNAs) in diverse disease processes—including cancer, neuropsychiatric conditions, and stroke—as regulators of gene expression and cellular signaling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "10"}]}, {"type": "t", "text": " In a recent study focused on ischemic stroke, application of a specialized subpathway analysis method (Subpathway‐LNCE) uncovered 11 lncRNAs that were centrally involved in dysregulated signaling routes. Among these, HCG17 emerged as a hub lncRNA whose altered expression was strongly associated with the stroke condition."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n The identification of HCG17 suggests that it functions as a competitive regulator in ischemic stroke by participating in endogenous RNA networks. In this context, HCG17 is hypothesized to modulate stroke‐related subpathways through its interactions with shared microRNAs, thereby influencing the expression of target messenger RNAs that orchestrate cellular responses during the evolution of stroke. This regulatory mechanism not only enhances our understanding of the molecular etiology of ischemic stroke but also positions HCG17 as a promising biomarker for early diagnosis and as a potential target for therapeutic intervention.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jerzy K Kulski "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "HCP5"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": ", a Hybrid HLA Class I Endogenous Retroviral Gene: Structure, Expression, and Disease Associations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells8050480"}], "href": "https://doi.org/10.3390/cells8050480"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31137555"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31137555"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hua Yuan, Hongliang Liu, Zhensheng Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Novel Genetic Variant in Long Non-coding RNA Gene NEXN-AS1 is Associated with Risk of Lung Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep34234"}], "href": "https://doi.org/10.1038/srep34234"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27713484"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27713484"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Johannes Pröll, Martin Danzer, Stephanie Stabentheiner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sequence capture and next generation resequencing of the MHC region highlights potential transplantation determinants in HLA identical haematopoietic stem cell transplantation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "DNA Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/dnares/dsr008"}], "href": "https://doi.org/10.1093/dnares/dsr008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21622977"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21622977"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Nirav M Amin, Panna Tandon, Erin Osborne Nishimura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNA-seq in the tetraploid Xenopus laevis enables genome-wide insight in a classic developmental biology model organism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Methods (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ymeth.2013.06.009"}], "href": "https://doi.org/10.1016/j.ymeth.2013.06.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23792920"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23792920"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Menachem Fromer, Panos Roussos, Solveig K Sieberts, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gene expression elucidates functional impact of polygenic risk for schizophrenia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Neurosci (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nn.4399"}], "href": "https://doi.org/10.1038/nn.4399"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27668389"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27668389"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jessada Thutkawkorapin, Hovsep Mahdessian, Tom Barber, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Two novel colorectal cancer risk loci in the region on chromosome 9q22.32."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.24340"}], "href": "https://doi.org/10.18632/oncotarget.24340"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29541405"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29541405"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Michael J Gandal, Pan Zhang, Evi Hadjimichael, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.aat8127"}], "href": "https://doi.org/10.1126/science.aat8127"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30545856"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30545856"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yoshiki Yasukochi, Jun Sakuma, Ichiro Takeuchi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of nine novel loci related to hematological traits in a Japanese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Physiol Genomics (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/physiolgenomics.00088.2017"}], "href": "https://doi.org/10.1152/physiolgenomics.00088.2017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29958078"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29958078"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Gary W Randall, Pickens A Gantt "}, {"type": "b", "children": [{"type": "t", "text": "Intrauterine insemination results in couples requiring extended semen transport time."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Fertil Womens Med (2007)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17987885"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17987885"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Yoriko Herai, Koichi Nishi, Hiroki Yamamoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[A case of primary choriocarcinoma of the mediastinum in a Japanese woman]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nihon Kokyuki Gakkai Zasshi (2006)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16780096"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16780096"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yanhua Zheng, Shaopeng Sun, Miao Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of potential hub-lncRNAs in ischemic stroke based on Subpathway-LNCE method."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.28554"}], "href": "https://doi.org/10.1002/jcb.28554"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30882937"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30882937"}]}]}]}