{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n HCG20, a long noncoding RNA, has been recently implicated in hepatocellular carcinoma (HCC) as part of an eight‐lncRNA prognostic signature that shows a strong association with tumor mutation burden and immune cell infiltration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although its precise molecular role remains to be fully defined, the inclusion of HCG20 in this prognostic model suggests that its altered expression in HCC may influence the tumor microenvironment and impact disease progression. Its potential involvement in competitive endogenous RNA (ceRNA) networks hints at a role in modulating gene expression that may, in turn, affect immune escape mechanisms and overall patient prognosis. Future studies are needed to elucidate the specific pathways and molecular interactions through which HCG20 contributes to HCC pathobiology, thereby establishing its value as a biomarker and potential therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Feng Qi, Xiaojing Du, Zhiying Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor Mutation Burden-Associated LINC00638/miR-4732-3p/ULBP1 Axis Promotes Immune Escape "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "via"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " PD-L1 in Hepatocellular Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2021.729340"}], "href": "https://doi.org/10.3389/fonc.2021.729340"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34568062"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34568062"}]}]}]}