{"type": "root", "children": [{"type": "t", "text": "<head>\n <meta charset=\"UTF-8\">\n <title>Summary of HCG23 Function</title>\n </head>\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Recent genomic investigations have implicated the HCG23 gene in autoimmune susceptibility. In a deep resequencing study of Korean ulcerative colitis (UC) patients, a single nucleotide variant (rs3117099) in HCG23 was identified with a statistically significant association (P = 9.98×10^–6; OR = 1.40) for increased UC risk, suggesting that HCG23 represents a novel susceptibility locus in this inflammatory condition."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although the precise molecular mechanisms by which HCG23 modulates disease remain to be fully characterized, its location within the major histocompatibility complex (MHC) region hints at a potential role in regulating immune responses at the transcriptional or epigenetic level. In support of the broader relevance of HCG family long non‐coding RNAs in autoimmunity, additional studies in pemphigus have uncovered associations between alleles of HCG lncRNAs and disease susceptibility, emphasizing a role for such regulatory RNA molecules in modulating immune function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chang Mo Moon, Seung Won Kim, Jae Bum Ahn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deep Resequencing of Ulcerative Colitis-Associated Genes Identifies Novel Variants in Candidate Genes in the Korean Population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Inflamm Bowel Dis (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/ibd/izy122"}], "href": "https://doi.org/10.1093/ibd/izy122"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29733354"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29733354"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Amanda Salviano-Silva, Mareike Becker, Danillo G Augusto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic association and differential expression of HLAComplexGroup lncRNAs in pemphigus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Autoimmun (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jaut.2021.102705"}], "href": "https://doi.org/10.1016/j.jaut.2021.102705"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34325306"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34325306"}]}]}]}