{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‑coding RNA HCG26 has emerged as a multifunctional regulatory molecule implicated in diverse human diseases. In one study of psoriatic disease, subtle but consistent differences in DNA methylation were detected within an HCG26‐associated region in sperm cells, and this epigenetic mark was prioritized among differentially methylated regions linked to skin and/or joint pathologies, suggesting that aberrant regulation of HCG26 may be one contributor to the missing heritability in psoriatic arthritis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In reproductive biology, HCG26 was found to be upregulated in granulosa cells from women with polycystic ovary syndrome (PCOS) and to correlate with antral follicle count; functional experiments in ovarian cell lines demonstrated that HCG26 promotes cell proliferation and modulates steroidogenesis—its knockdown not only inhibited cell‐cycle progression but also enhanced aromatase expression and estradiol production—thus implicating HCG26 in both folliculogenesis and androgen–estrogen balance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, in the context of ischemic stroke, high‐throughput RNA sequencing of patient blood samples identified HCG26 among several long non‑coding RNAs with altered expression, indicating a potential role in the regulatory networks underpinning stroke pathophysiology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Finally, structural genomic analyses in nasopharyngeal carcinoma uncovered copy number variations overlapping a region that includes HCG26, with a suggestive association to disease susceptibility, thereby extending the potential clinical impact of HCG26 to oncogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these findings highlight the multifaceted involvement of HCG26 in mediating epigenetic regulation, cell proliferation, and cellular differentiation processes, as well as its possible contribution to cancer predisposition, warranting further investigations into its mechanistic roles across different disease contexts.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Remy A Pollock, Laila Zaman, Vinod Chandran, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epigenome-wide analysis of sperm cells identifies IL22 as a possible germ line risk locus for psoriatic arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0212043"}], "href": "https://doi.org/10.1371/journal.pone.0212043"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30779748"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30779748"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yu-Dong Liu, Ying Li, Shu-Xian Feng, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Altered Long Non-Coding RNA Transcriptomic Profiles in Ischemic Stroke."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Gene Ther (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/hum.2017.064"}], "href": "https://doi.org/10.1089/hum.2017.064"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29284304"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29284304"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Joyce Siew Yong Low, Yoon Ming Chin, Taisei Mushiroda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Genome Wide Study of Copy Number Variation Associated with Nasopharyngeal Carcinoma in Malaysian Chinese Identifies CNVs at 11q14.3 and 6p21.3 as Candidate Loci."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0145774"}], "href": "https://doi.org/10.1371/journal.pone.0145774"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26730743"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26730743"}]}]}]}