HCP5B Gene

Name HLA complex P5B (non-protein coding)
Summary
{"type": "root", "children": [{"type": "t", "text": "<head>\n <meta charset=\"UTF-8\">\n <title>Summary of HCP5B Function in the Provided Abstracts</title>\n </head>\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n A careful review of the abstracts provided reveals that none of them include any mention of HCP5B or data addressing its molecular or physiological function. Although the collection spans a wide variety of biomedical research areas—including X‐chromosome inactivation and chromatin regulation (for example"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": ", to vaccine candidate development and immunological epitope mapping (for example"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "8"}]}, {"type": "t", "text": ", as well as genetic studies of traits ranging from central corneal thickness"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "to pediatric multiple sclerosis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "—none of these reports address or characterize HCP5B.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, other abstracts in the set focus on topics such as gene‐regulatory network modeling"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": ", plant secondary metabolism"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": ", and the biochemical characterization of enzymes involved in natural product synthesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": " A separate study reviews aspects of mental health, particularly emotional distress and body image disorders"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": ", and another investigates the dynamics of chromosomal pairing in relation to Xist regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": " \n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Taken together, while the abstracts collectively provide insights into diverse aspects of gene regulation, host–pathogen interactions, chromatin organization, immune epitope specificity, and other clinically relevant phenomena, there is no experimental evidence or discussion regarding HCP5B in any of these reports. Consequently, based on the information contained in the provided abstracts, one cannot ascribe any specific function to HCP5B.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, although the abstracts cover important regulatory and immunological processes, none include data on HCP5B; therefore, its function remains undiscussed in this set of publications.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Maud Borensztein, Laurène Syx, Katia Ancelin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Xist-dependent imprinted X inactivation and the early developmental consequences of its failure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nsmb.3365"}], "href": "https://doi.org/10.1038/nsmb.3365"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28134930"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28134930"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Aurélie Bousard, Ana Cláudia Raposo, Jan Jakub Żylicz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The role of Xist-mediated Polycomb recruitment in the initiation of X-chromosome inactivation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embr.201948019"}], "href": "https://doi.org/10.15252/embr.201948019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31456285"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31456285"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jan Jakub Żylicz, Aurélie Bousard, Kristina Žumer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Implication of Early Chromatin Changes in X Chromosome Inactivation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2018.11.041"}], "href": "https://doi.org/10.1016/j.cell.2018.11.041"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30595450"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30595450"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Maud Borensztein, Ikuhiro Okamoto, Laurène Syx, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Structural organization of the inactive X chromosome in the mouse."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature18589"}], "href": "https://doi.org/10.1038/nature18589"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27437574"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27437574"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Madeleine Dahlbäck, Thomas S Rask, Pernille H Andersen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epitope mapping and topographic analysis of VAR2CSA DBL3X involved in P. falciparum placental sequestration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Pathog (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.ppat.0020124"}], "href": "https://doi.org/10.1371/journal.ppat.0020124"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17112315"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17112315"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yu-Huang Zhu, Yan-Feng Gao, Fei Chen, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Direct ex vivo detection of HLA-DR3-restricted cytomegalovirus- and Mycobacterium tuberculosis-specific CD4+ T cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Immunol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.humimm.2005.06.011"}], "href": "https://doi.org/10.1016/j.humimm.2005.06.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16360834"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16360834"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Xiaoyi Gao, W James Gauderman, Yutao Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A genome-wide association study of central corneal thickness in Latinos."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Invest Ophthalmol Vis Sci (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1167/iovs.13-11692"}], "href": "https://doi.org/10.1167/iovs.13-11692"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23493294"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23493294"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "J P McElroy, L B Krupp, B A Johnson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Copy number variation in pediatric multiple sclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mult Scler (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1352458512469696"}], "href": "https://doi.org/10.1177/1352458512469696"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23239789"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23239789"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Verena Mutzel, Ikuhiro Okamoto, Ilona Dunkel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A symmetric toggle switch explains the onset of random X inactivation in different mammals."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41594-019-0214-1"}], "href": "https://doi.org/10.1038/s41594-019-0214-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30962582"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30962582"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Ting Wu, Yejun Wang, Dianjing Guo "}, {"type": "b", "children": [{"type": "t", "text": "Investigation of glandular trichome proteins in Artemisia annua L. using comparative proteomics."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0041822"}], "href": "https://doi.org/10.1371/journal.pone.0041822"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22905110"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22905110"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Jongtae Yang, Hui Xu, Yirong Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nucleotidylation of unsaturated carbasugar in validamycin biosynthesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Org Biomol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1039/c0ob00475h"}], "href": "https://doi.org/10.1039/c0ob00475h"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20981366"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20981366"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Alastair Dobbin, Sheila Ross "}, {"type": "b", "children": [{"type": "t", "text": "How Memory Structures Influence Distress and Recovery."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Psychiatry (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fpsyt.2019.00500"}], "href": "https://doi.org/10.3389/fpsyt.2019.00500"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31427994"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31427994"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Deborah Mitchison, Rocco Crino, Phillipa Hay "}, {"type": "b", "children": [{"type": "t", "text": "The presence, predictive utility, and clinical significance of body dysmorphic symptoms in women with eating disorders."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Eat Disord (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/2050-2974-1-20"}], "href": "https://doi.org/10.1186/2050-2974-1-20"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24999401"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24999401"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Osamu Masui, Isabelle Bonnet, Patricia Le Baccon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Live-cell chromosome dynamics and outcome of X chromosome pairing events during ES cell differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2011.03.032"}], "href": "https://doi.org/10.1016/j.cell.2011.03.032"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21529716"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21529716"}]}]}]}
Synonyms P5.9, HCP5P10, P5-10
NCBI Gene ID 352990
API
Download Associations
Predicted Functions View HCP5B's ARCHS4 Predicted Functions.
Co-expressed Genes View HCP5B's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View HCP5B's ARCHS4 Predicted Functions.

Functional Associations

HCP5B has 93 functional associations with biological entities spanning 5 categories (organism, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 5 datasets.

Click the + buttons to view associations for HCP5B from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles tissues with high or low expression of HCP5B gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
GEO Signatures of Differentially Expressed Genes for Diseases disease perturbations changing expression of HCP5B gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of HCP5B gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations transcription factor perturbations changing expression of HCP5B gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Viral Infections virus perturbations changing expression of HCP5B gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.