{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n HECTD2‐AS1 is a long noncoding RNA that has been identified as aberrantly expressed in muscle‐invasive bladder cancer, where it appears to function within a competing endogenous RNA (ceRNA) network by acting as a microRNA sponge. This regulatory role suggests that HECTD2‐AS1 contributes to the modulation of mRNA expression, thereby impacting tumorigenesis, cancer progression, and patient prognosis by influencing key cellular pathways in cancerous tissues."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In parallel, recent transcriptomic studies on statin‐induced myalgia and statin-related myotoxicity have revealed that skeletal muscle from affected patients exhibits perturbations in cellular stress, inflammatory, apoptotic, and regenerative pathways"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ";."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Although HECTD2‐AS1 has not been directly examined in the context of statin-associated muscle injury, its established function as a ceRNA suggests that it might also be involved in modulating muscle stress response or repair processes. Future research integrating comprehensive transcriptomic and functional analyses may uncover whether HECTD2‐AS1 plays a contributory role in the molecular pathways underlying statin-induced myopathy.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hanbo Wang, Leilei Niu, Shaobo Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive analysis of aberrantly expressed profiles of lncRNAs and miRNAs with associated ceRNA network in muscle-invasive bladder cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.13363"}], "href": "https://doi.org/10.18632/oncotarget.13363"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27863388"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27863388"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Marshall B Elam, Gipsy Majumdar, Khyobeni Mozhui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Patients experiencing statin-induced myalgia exhibit a unique program of skeletal muscle gene expression following statin re-challenge."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0181308"}], "href": "https://doi.org/10.1371/journal.pone.0181308"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28771594"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28771594"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Richard Myles Turner, Munir Pirmohamed "}, {"type": "b", "children": [{"type": "t", "text": "Statin-Related Myotoxicity: A Comprehensive Review of Pharmacokinetic, Pharmacogenomic and Muscle Components."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/jcm9010022"}], "href": "https://doi.org/10.3390/jcm9010022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31861911"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31861911"}]}]}]}