{"type": "root", "children": [{"type": "t", "text": "<head>\n <meta charset=\"UTF-8\">\n <title>Summary of HELLPAR Function</title>\n </head>\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n HELLPAR appears to function as a regulatory long non‐coding RNA implicated in distinct biological contexts. In pancreatic cancer, HELLPAR is predicted to act as an upstream regulator within a lncRNA/pseudogene–miRNA–mRNA network that modulates the hsa‑miR‑30d‑5p/GJA1 axis. This network is associated with metastatic potential, where HELLPAR (together with other non‐coding RNAs) may fine‑tune the expression of key adhesion and signaling molecules, ultimately influencing cancer cell dissemination."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the context of pregnancy, integrative transcriptomic analyses of myometrial tissues at the onset of term labor have identified HELLPAR as one of several top lncRNA hubs that converge with microRNAs and transcription factors such as NFKB1, RELA, and ESR1. This regulatory network appears to drive the transformation of myometrial cells toward an estrogen‐sensitive, contractile phenotype, which is essential for the initiation of labor."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, a related long non‐coding RNA, LINC‑HELLP, which is genetically linked to the pregnancy‑specific HELLP syndrome, has been shown to influence the differentiation of first‑trimester extravillous trophoblasts. Mutations in LINC‑HELLP adversely affect the balance between proliferation and invasion by altering interactions with protein networks involved in RNA splicing and ribosomal function, thereby underscoring the significant role of such transcripts in placental development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these findings suggest that HELLPAR and related non‐coding transcripts serve as critical regulatory hubs that orchestrate gene expression programs relevant to both oncogenic metastasis and key pregnancy processes, including myometrial remodeling and trophoblast differentiation.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Huilin Zheng, Bisha Ding, Ke Xue, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Construction of a lncRNA/pseudogene-hsa-miR-30d-5p-GJA1 regulatory network related to metastasis of pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genomics (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ygeno.2021.04.013"}], "href": "https://doi.org/10.1016/j.ygeno.2021.04.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33839271"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33839271"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Sonika Tyagi, Eng-Cheng Chan, Daniel Barker, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptomic analysis reveals myometrial topologically associated domains linked to the onset of human term labour."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Hum Reprod (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/molehr/gaac003"}], "href": "https://doi.org/10.1093/molehr/gaac003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35150271"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35150271"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Marie van Dijk, Allerdien Visser, Kwadwo M L Buabeng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations within the LINC-HELLP non-coding RNA differentially bind ribosomal and RNA splicing complexes and negatively affect trophoblast differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddv274"}], "href": "https://doi.org/10.1093/hmg/ddv274"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26173455"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26173455"}]}]}]}