HELLS Gene

Name	helicase, lymphoid-specific
Description	This gene encodes a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2014]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n HELLS (also known as LSH) is a SWI2/SNF2 family chromatin remodeling ATPase that plays a central role in establishing and maintaining proper DNA methylation patterns during development and differentiation. It facilitates de novo methylation and stable gene silencing by promoting the recruitment and/or binding of DNA methyltransferases and histone methyltransferase complexes to specific genomic loci—including gene promoters, repeat elements, and developmentally regulated genes—which in turn preserves genomic stability and prevents aberrant transcription."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": " \n In pluripotent cells and during early differentiation, HELLS is required for timely silencing of stem cell–specific genes (for example, Oct4) and for repressing retrotransposons to ensure proper lineage commitment and to prevent genomic instability; disruption of its function can lead to premature senescence and developmental defects."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": " \n In cancer, HELLS is frequently upregulated and acts as an epigenetic driver by remodeling nucleosome occupancy at transcription start sites and enhancers, thereby repressing tumor suppressor genes (such as p16INK4a) and cooperating with oncogenic transcription factors like FOXM1, E2F3, and SP1 to promote proliferation, invasion, and metastasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "14"}]}, {"type": "t", "text": " \n Moreover, mutations in HELLS underlie a subtype of immunodeficiency–centromeric instability–facial anomalies (ICF) syndrome, underscoring its importance in directing methylation at pericentromeric regions and maintaining chromosomal integrity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "17"}]}, {"type": "t", "text": " \n In addition to its roles in epigenetic silencing, HELLS is critical for proper DNA repair and meiotic recombination; it collaborates with DNA-binding proteins such as PRDM9 to open chromatin at recombination hotspots, thereby promoting proper double-strand break formation and repair."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": " \n HELLS can also modulate transcript stability and influence other regulators of the epigenome—in some contexts upregulating factors like TET2 via miRNA silencing—and delays cellular senescence by recruiting histone deacetylases to repress p16INK4a."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "20"}]}, {"type": "t", "text": " \n Collectively, these findings highlight HELLS as an indispensable epigenetic regulator whose diverse functions span from normal development and maintenance of genome stability to oncogenic reprogramming and disease.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kevin Myant, Ausma Termanis, Arvind Y M Sundaram, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LSH and G9a/GLP complex are required for developmentally programmed DNA methylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genome Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gr.108498.110"}], "href": "https://doi.org/10.1101/gr.108498.110"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21149390"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21149390"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Weishi Yu, Carl McIntosh, Ryan Lister, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide DNA methylation patterns in LSH mutant reveals de-repression of repeat elements and redundant epigenetic silencing pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genome Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gr.172015.114"}], "href": "https://doi.org/10.1101/gr.172015.114"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25170028"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25170028"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Donncha S Dunican, Hazel A Cruickshanks, Masako Suzuki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lsh regulates LTR retrotransposon repression independently of Dnmt3b function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genome Biol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/gb-2013-14-12-r146"}], "href": "https://doi.org/10.1186/gb-2013-14-12-r146"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24367978"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24367978"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yongguang Tao, Sichuan Xi, Victorino Briones, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lsh mediated RNA polymerase II stalling at HoxC6 and HoxC8 involves DNA methylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0009163"}], "href": "https://doi.org/10.1371/journal.pone.0009163"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20161795"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20161795"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Lin-Quan Sun, David W Lee, Quangeng Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.1176104"}], "href": "https://doi.org/10.1101/gad.1176104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15105378"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15105378"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Sichuan Xi, Theresa M Geiman, Victorino Briones, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lsh participates in DNA methylation and silencing of stem cell genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cells (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/stem.183"}], "href": "https://doi.org/10.1002/stem.183"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19650037"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19650037"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Rabindranath De La Fuente, Claudia Baumann, Tao Fan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lsh is required for meiotic chromosome synapsis and retrotransposon silencing in female germ cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1513"}], "href": "https://doi.org/10.1038/ncb1513"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17115026"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17115026"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Cheuk-Ting Law, Lai Wei, Felice Ho-Ching Tsang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HELLS Regulates Chromatin Remodeling and Epigenetic Silencing of Multiple Tumor Suppressor Genes in Human Hepatocellular Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.30414"}], "href": "https://doi.org/10.1002/hep.30414"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30516846"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30516846"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Ahmad Waseem, Muhammad Ali, Edward W Odell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downstream targets of FOXM1: CEP55 and HELLS are cancer progression markers of head and neck squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oral Oncol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.oraloncology.2010.03.022"}], "href": "https://doi.org/10.1016/j.oraloncology.2010.03.022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20400365"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20400365"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Muy-Teck Teh, Emilios Gemenetzidis, Deeviyaben Patel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FOXM1 induces a global methylation signature that mimics the cancer epigenome in head and neck squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0034329"}], "href": "https://doi.org/10.1371/journal.pone.0034329"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22461910"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22461910"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Björn von Eyss, Jonas Maaskola, Sebastian Memczak, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The SNF2-like helicase HELLS mediates E2F3-dependent transcription and cellular transformation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/emboj.2011.451"}], "href": "https://doi.org/10.1038/emboj.2011.451"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22157815"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22157815"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Xiaozhen He, Bin Yan, Shuang Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chromatin Remodeling Factor LSH Drives Cancer Progression by Suppressing the Activity of Fumarate Hydratase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-16-0268"}], "href": "https://doi.org/10.1158/0008-5472.CAN-16-0268"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27302170"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27302170"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Rui Yang, Na Liu, Ling Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LSH interacts with and stabilizes GINS4 transcript that promotes tumourigenesis in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-019-1276-y"}], "href": "https://doi.org/10.1186/s13046-019-1276-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31253190"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31253190"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Ranran Wang, Ying Shi, Ling Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The ratio of FoxA1 to FoxA2 in lung adenocarcinoma is regulated by LncRNA HOTAIR and chromatin remodeling factor LSH."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep17826"}], "href": "https://doi.org/10.1038/srep17826"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26658322"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26658322"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Peter E Thijssen, Yuya Ito, Giacomo Grillo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in CDCA7 and HELLS cause immunodeficiency-centromeric instability-facial anomalies syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms8870"}], "href": "https://doi.org/10.1038/ncomms8870"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26216346"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26216346"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Christopher Jenness, Simona Giunta, Manuel M Müller, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1717509115"}], "href": "https://doi.org/10.1073/pnas.1717509115"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29339483"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29339483"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Guillaume Velasco, Giacomo Grillo, Nizar Touleimat, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comparative methylome analysis of ICF patients identifies heterochromatin loci that require ZBTB24, CDCA7 and HELLS for their methylated state."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddy130"}], "href": "https://doi.org/10.1093/hmg/ddy130"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29659838"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29659838"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Motoko Unoki, Hironori Funabiki, Guillaume Velasco, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CDCA7 and HELLS mutations undermine nonhomologous end joining in centromeric instability syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI99751"}], "href": "https://doi.org/10.1172/JCI99751"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30307408"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30307408"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Catrina Spruce, Sibongakonke Dlamini, Guruprasad Ananda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HELLS and PRDM9 form a pioneer complex to open chromatin at meiotic recombination hot spots."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.333542.119"}], "href": "https://doi.org/10.1101/gad.333542.119"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32001511"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32001511"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Jiantao Jia, Ying Shi, Ling Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Decrease in Lymphoid Specific Helicase and 5-hydroxymethylcytosine Is Associated with Metastasis and Genome Instability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Theranostics (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/thno.21389"}], "href": "https://doi.org/10.7150/thno.21389"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29109788"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29109788"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Rui Zhou, Limin Han, Guodong Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Senescence delay and repression of p16INK4a by Lsh via recruitment of histone deacetylases in human diploid fibroblasts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkp533"}], "href": "https://doi.org/10.1093/nar/gkp533"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19561196"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19561196"}]}]}]}
Synonyms	NBLA10143, SMARCA6, LSH, ICF4, PASG
Proteins	HELLS_HUMAN
NCBI Gene ID	3070
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

HELLS has 10,105 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 123 datasets.

Click the + buttons to view associations for HELLS from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

HELLS Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by HELLS gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of HELLS gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of HELLS gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of HELLS gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of HELLS gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of HELLS gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of HELLS gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of HELLS gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of HELLS gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of HELLS gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of HELLS gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of HELLS gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with HELLS protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with HELLS gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of HELLS gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of HELLS gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of HELLS gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with HELLS gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of HELLS gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing HELLS protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing HELLS protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with HELLS protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with HELLS protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of HELLS gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with HELLS gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with HELLS gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with HELLS gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of HELLS protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by HELLS gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with HELLS gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with HELLS gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with HELLS gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with HELLS gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at HELLS gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of HELLS gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of HELLS gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing HELLS from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with HELLS gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with HELLS gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of HELLS gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.