{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent research has underscored the importance of long non‐coding RNAs (lncRNAs) in cancer biology, particularly in hepatocellular carcinoma (HCC). One such lncRNA, HISLA—also referred to as LINC01146—has been implicated in the development of HCC, where it is proposed to regulate key cellular processes that govern tumor initiation and progression. Although the precise mechanisms remain to be fully elucidated, HISLA appears poised to influence gene expression and associated signaling pathways, thereby affecting cell proliferation, survival, and potentially metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFocused investigation into HISLA’s function suggests that its dysregulation may contribute to the molecular events driving liver cancer pathogenesis. By mediating critical steps in cellular homeostasis and the oncogenic process, HISLA is emerging as a promising biomarker and a potential target for therapeutic intervention in HCC. Continued research on HISLA will likely clarify its role in HCC’s complex regulatory networks and may ultimately inform the development of novel treatment strategies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiaoyun Ma, Meile Mo, Chao Tan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Liver-specific LINC01146, a promising prognostic indicator, inhibits the malignant phenotype of hepatocellular carcinoma cells both in vitro and in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12967-021-03225-2"}], "href": "https://doi.org/10.1186/s12967-021-03225-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35101062"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35101062"}]}]}]}