| HGNC Family | Immunoglobulin superfamily domain containing, Histocompatibility complex (HLA) |
| Name | major histocompatibility complex, class I, C |
| Description | HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. About 6000 HLA-C alleles have been described. The HLA system plays an important role in the occurrence and outcome of infectious diseases, including those caused by the malaria parasite, the human immunodeficiency virus (HIV), and the severe acute respiratory syndrome coronavirus (SARS-CoV). The structural spike and the nucleocapsid proteins of the novel coronavirus SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19), are reported to contain multiple Class I epitopes with predicted HLA restrictions. Individual HLA genetic variation may help explain different immune responses to a virus across a population.[provided by RefSeq, Aug 2020] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n The classical major histocompatibility complex (MHC) class I molecule HLA‐C plays multifaceted roles in immune regulation. In adaptive immunity, HLA‐C presents peptides to cytotoxic T lymphocytes, and in innate immunity its cell‐surface expression levels, which are controlled by regulatory polymorphisms (e.g. within the 3′ untranslated region affecting microRNA binding), modulate antiviral responses – most notably influencing HIV‐1 control and disease progression (see."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": " In autoimmune conditions such as psoriasis and psoriatic arthritis, a specific HLA‐C allele (HLA‐Cw6) is a primary risk determinant, and its interaction with antigen‐processing enzymes (for example, ERAP1) suggests that fine‐tuning of peptide presentation by HLA‐C critically influences disease susceptibility."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "9"}]}, {"type": "t", "text": " Moreover, in the setting of allogeneic transplantation, mismatches at the HLA‐C locus adversely impact outcomes such as acute graft‐versus‐host disease and overall survival, underscoring its importance in donor–recipient immune compatibility."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "12"}]}, {"type": "t", "text": " In addition, HLA‐C is central to the regulation of natural killer (NK) cell functions by serving as the primary ligand for killer immunoglobulin‐like receptors (KIRs). Differential binding of inhibitory and activating KIRs to HLA‐C allotypes (grouped as C1 and C2) influences NK cell education, cytotoxicity, and cytokine release, which in turn affects processes such as tumor surveillance and placentation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "17"}]}, {"type": "t", "text": " Together, these studies highlight that HLA‐C not only contributes to antigen presentation for adaptive immune responses but also regulates innate immune functions through its interactions with NK cell receptors, influencing viral control, autoimmunity, transplantation outcomes, and maternal–fetal tolerance.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jacques Fellay, Kevin V Shianna, Dongliang Ge, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A whole-genome association study of major determinants for host control of HIV-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1143767"}], "href": "https://doi.org/10.1126/science.1143767"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17641165"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17641165"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Florencia Pereyra, Xiaoming Jia, Paul J McLaren, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The major genetic determinants of HIV-1 control affect HLA class I peptide presentation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1195271"}], "href": "https://doi.org/10.1126/science.1195271"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21051598"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21051598"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Smita Kulkarni, Ram Savan, Ying Qi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential microRNA regulation of HLA-C expression and its association with HIV control."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature09914"}], "href": "https://doi.org/10.1038/nature09914"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21499264"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21499264"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Rasmi Thomas, Richard Apps, Ying Qi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HLA-C cell surface expression and control of HIV/AIDS correlate with a variant upstream of HLA-C."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.486"}], "href": "https://doi.org/10.1038/ng.486"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19935663"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19935663"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Sophie Limou, Sigrid Le Clerc, Cédric Coulonges, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Infect Dis (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1086/596067"}], "href": "https://doi.org/10.1086/596067"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19115949"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19115949"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Rajan P Nair, Kristina Callis Duffin, Cynthia Helms, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.311"}], "href": "https://doi.org/10.1038/ng.311"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19169254"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19169254"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Rajan P Nair, Philip E Stuart, Ioana Nistor, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1086/503821"}], "href": "https://doi.org/10.1086/503821"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16642438"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16642438"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Rafael de Cid, Eva Riveira-Munoz, Patrick L J M Zeeuwen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.313"}], "href": "https://doi.org/10.1038/ng.313"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19169253"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19169253"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Francesca Capon, Michael H Allen, Mahreen Ameen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A synonymous SNP of the corneodesmosin gene leads to increased mRNA stability and demonstrates association with psoriasis across diverse ethnic groups."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddh273"}], "href": "https://doi.org/10.1093/hmg/ddh273"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15333584"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15333584"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Stephanie J Lee, John Klein, Michael Haagenson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2007-06-097386"}], "href": "https://doi.org/10.1182/blood-2007-06-097386"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17785583"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17785583"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Neal Flomenberg, Lee Ann Baxter-Lowe, Dennis Confer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2004-03-0803"}], "href": "https://doi.org/10.1182/blood-2004-03-0803"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15191952"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15191952"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Yasuo Morishima, Takehiko Sasazuki, Hidetoshi Inoko, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The clinical significance of human leukocyte antigen (HLA) allele compatibility in patients receiving a marrow transplant from serologically HLA-A, HLA-B, and HLA-DR matched unrelated donors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood.v99.11.4200"}], "href": "https://doi.org/10.1182/blood.v99.11.4200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12010826"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12010826"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Achim K Moesta, Paul J Norman, Makoto Yawata, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Synergistic polymorphism at two positions distal to the ligand-binding site makes KIR2DL2 a stronger receptor for HLA-C than KIR2DL3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.180.6.3969"}], "href": "https://doi.org/10.4049/jimmunol.180.6.3969"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18322206"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18322206"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Susan E Hiby, Richard Apps, Andrew M Sharkey, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Maternal activating KIRs protect against human reproductive failure mediated by fetal HLA-C2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI43998"}], "href": "https://doi.org/10.1172/JCI43998"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20972337"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20972337"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "S E Hiby, L Regan, W Lo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of maternal killer-cell immunoglobulin-like receptors and parental HLA-C genotypes with recurrent miscarriage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Reprod (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/humrep/den011"}], "href": "https://doi.org/10.1093/humrep/den011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18263639"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18263639"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Shiqiu Xiong, Andrew M Sharkey, Philippa R Kennedy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Maternal uterine NK cell-activating receptor KIR2DS1 enhances placentation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI68991"}], "href": "https://doi.org/10.1172/JCI68991"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24091323"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24091323"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Thorsten Graef, Achim K Moesta, Paul J Norman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "KIR2DS4 is a product of gene conversion with KIR3DL2 that introduced specificity for HLA-A*11 while diminishing avidity for HLA-C."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20091010"}], "href": "https://doi.org/10.1084/jem.20091010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19858347"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19858347"}]}]}]}
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| Synonyms | HLA-JY3, D6S204, HLC-C, HLAC, PSORS1 |
| Proteins | 1C03_HUMAN |
| NCBI Gene ID | 3107 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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HLA-C has 11,595 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 104 datasets.
Click the + buttons to view associations for HLA-C from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Achilles Cell Line Gene Essentiality Profiles | cell lines with fitness changed by HLA-C gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset. | |
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of HLA-C gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of HLA-C gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of HLA-C gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of HLA-C gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of HLA-C gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of HLA-C gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of HLA-C gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| CCLE Cell Line Proteomics | Cell lines associated with HLA-C protein from the CCLE Cell Line Proteomics dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with HLA-C gene from the CellMarker Gene-Cell Type Associations dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of HLA-C gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of HLA-C gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of HLA-C gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of HLA-C gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing HLA-C protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing HLA-C protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with HLA-C protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with HLA-C protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of HLA-C gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with HLA-C gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| CTD Gene-Chemical Interactions | chemicals interacting with HLA-C gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
| CTD Gene-Disease Associations | diseases associated with HLA-C gene/protein from the curated CTD Gene-Disease Associations dataset. | |
| dbGAP Gene-Trait Associations | traits associated with HLA-C gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset. | |
| DeepCoverMOA Drug Mechanisms of Action | small molecule perturbations with high or low expression of HLA-C protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by HLA-C gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Curated Gene-Disease Association Evidence Scores | diseases involving HLA-C gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Curated Gene-Disease Association Evidence Scores 2025 | diseases involving HLA-C gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores | diseases associated with HLA-C gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with HLA-C gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with HLA-C gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with HLA-C gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with HLA-C gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with HLA-C gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| GAD Gene-Disease Associations | diseases associated with HLA-C gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
| GAD High Level Gene-Disease Associations | diseases associated with HLA-C gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
| GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of HLA-C gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with HLA-C gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing HLA-C from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of HLA-C gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of HLA-C gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of HLA-C gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of HLA-C gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of HLA-C gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of HLA-C gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GlyGen Glycosylated Proteins | ligands (chemical) binding HLA-C protein from the GlyGen Glycosylated Proteins dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving HLA-C gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving HLA-C gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2023 | cellular components containing HLA-C protein from the curated GO Cellular Component Annotations 2023 dataset. | |
| GO Cellular Component Annotations 2025 | cellular components containing HLA-C protein from the curated GO Cellular Component Annotations 2025 dataset. | |
| GTEx eQTL | SNPs regulating expression of HLA-C gene from the GTEx eQTL dataset. | |
| GTEx eQTL 2025 | SNPs regulating expression of HLA-C gene from the GTEx eQTL 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of HLA-C gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of HLA-C gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of HLA-C gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of HLA-C gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
| GWAS Catalog SNP-Phenotype Associations | phenotypes associated with HLA-C gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset. | |
| GWASdb SNP-Disease Associations | diseases associated with HLA-C gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
| GWASdb SNP-Phenotype Associations | phenotypes associated with HLA-C gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
| HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of HLA-C gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of HLA-C gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of HLA-C gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
| Hub Proteins Protein-Protein Interactions | interacting hub proteins for HLA-C from the curated Hub Proteins Protein-Protein Interactions dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with HLA-C gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for HLA-C protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of HLA-C gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| KEGG Pathways | pathways involving HLA-C protein from the KEGG Pathways dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of HLA-C gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of HLA-C gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of HLA-C gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of HLA-C gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of HLA-C gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
| LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of HLA-C gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| LOCATE Curated Protein Localization Annotations | cellular components containing HLA-C protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain HLA-C protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MiRTarBase microRNA Targets | microRNAs targeting HLA-C gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of HLA-C gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| MSigDB Cancer Gene Co-expression Modules | co-expressed genes for HLA-C from the MSigDB Cancer Gene Co-expression Modules dataset. | |
| NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of HLA-C gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
| OMIM Gene-Disease Associations | phenotypes associated with HLA-C gene from the curated OMIM Gene-Disease Associations dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for HLA-C from the Pathway Commons Protein-Protein Interactions dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of HLA-C gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PFOCR Pathway Figure Associations 2023 | pathways involving HLA-C protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving HLA-C protein from the Wikipathways PFOCR 2024 dataset. | |
| Reactome Pathways 2014 | pathways involving HLA-C protein from the Reactome Pathways dataset. | |
| Reactome Pathways 2024 | pathways involving HLA-C protein from the Reactome Pathways 2024 dataset. | |
| Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of HLA-C gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
| Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of HLA-C gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset. | |
| Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of HLA-C gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
| Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of HLA-C gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
| Roadmap Epigenomics Cell and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of HLA-C gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of HLA-C gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of HLA-C gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Sanger Dependency Map Cancer Cell Line Proteomics | cell lines associated with HLA-C protein from the Sanger Dependency Map Cancer Cell Line Proteomics dataset. | |
| Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of HLA-C gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of HLA-C gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of HLA-C gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of HLA-C protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of HLA-C protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of HLA-C protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of HLA-C protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with HLA-C protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with HLA-C protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
| WikiPathways Pathways 2014 | pathways involving HLA-C protein from the Wikipathways Pathways 2014 dataset. | |
| WikiPathways Pathways 2024 | pathways involving HLA-C protein from the WikiPathways Pathways 2024 dataset. | |
