{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‐coding RNA HLA-DQB1-AS1 has emerged as a multifunctional regulatory molecule with roles in both normal physiology and tumorigenesis. In the context of muscle function, genetic association studies have identified HLA-DQB1-AS1 as a candidate gene influencing hand grip strength, thereby implicating it in muscle performance and potentially in sarcopenia."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In several cancer types—including lung adenocarcinoma, hepatocellular carcinoma, and melanoma—HLA-DQB1-AS1 has been incorporated into distinct prognostic lncRNA risk models. For instance, in lung adenocarcinoma and melanoma, its inclusion in autophagy- and immune-related lncRNA signatures has been shown to correlate with patient survival outcomes, immune microenvironment characteristics, and differential responses to chemotherapeutic or immunotherapeutic agents."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "5"}]}, {"type": "t", "text": " Moreover, in hepatocellular carcinoma, functional assays have demonstrated that regulatory SNPs can modulate HLA-DQB1-AS1 expression via CTCF-mediated long-range enhancer–promoter interactions, with increased expression promoting oncogenic cell proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Similarly, in cutaneous melanoma, HLA-DQB1-AS1 is part of an immune-related lncRNA prognostic signature linked to enhanced immune infiltration and improved responses to immune checkpoint blockade."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Collectively, these studies suggest that HLA-DQB1-AS1 plays a pivotal role in modulating gene expression networks involved in autophagy, immune responses, and oncogenic signaling pathways, thereby influencing both muscle phenotypes and tumor progression.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Abhishek Narain Singh, Bili Gasman "}, {"type": "b", "children": [{"type": "t", "text": "Disentangling the genetics of sarcopenia: prioritization of NUDT3 and KLF5 as genes for lean mass & HLA-DQB1-AS1 for hand grip strength with the associated enhancing SNPs & a scoring system."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Med Genet (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12881-020-0977-6"}], "href": "https://doi.org/10.1186/s12881-020-0977-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32093658"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32093658"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Boxuan Liu, Shuanying Yang "}, {"type": "b", "children": [{"type": "t", "text": "A Five Autophagy-Related Long Non-Coding RNA Prognostic Model for Patients with Lung Adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Gen Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/IJGM.S334601"}], "href": "https://doi.org/10.2147/IJGM.S334601"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34737609"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34737609"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Liwei Wu, Zilu Wen, Yanzheng Song, et al. 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