{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n HM13‐AS1 is a long non‐coding RNA that appears to be involved in the regulation of cancer cell growth. In a high‐throughput CRISPR‐Cas9 deletion screen, perturbation of candidate lncRNAs—including HM13‐AS1—was shown to either enhance or suppress tumor cell proliferation, suggesting that HM13‐AS1 may function as a modulator of oncogenic or tumor suppressive cellular programs."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In a separate multi‐omics analysis of colorectal cancer, deregulation of lncRNAs driven by copy number variations was linked to poor patient prognosis. Although HM13‐AS1 was not explicitly listed among the ten lncRNAs forming the prognostic signature, its categorization among functionally important lncRNAs highlights the broader role that genomic and epigenomic aberrations can play in disease progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, while large‐scale genome wide association studies of complex traits such as corneal curvature have primarily implicated coding genes and other non‐coding elements, the diversity of regulatory roles occupied by lncRNAs like HM13‐AS1 reinforces the concept that non‐coding RNAs can have pleiotropic effects. These effects may extend from cell proliferation in cancer to the regulation of structural and developmental eye characteristics, emphasizing the extensive influence of non‐coding transcription in human biology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, HM13‐AS1 functions as a key regulatory component within the network of long non‐coding RNAs influencing cell growth and malignancy, and its study within various genomic contexts underscores the importance of non‐coding elements in both oncogenesis and other complex human traits.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shiyou Zhu, Wei Li, Jingze Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-scale deletion screening of human long non-coding RNAs using a paired-guide RNA CRISPR-Cas9 library."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Biotechnol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nbt.3715"}], "href": "https://doi.org/10.1038/nbt.3715"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27798563"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27798563"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Huimin Liu, Xiaoyu Gu, Guihua Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Copy number variations primed lncRNAs deregulation contribute to poor prognosis in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.102168"}], "href": "https://doi.org/10.18632/aging.102168"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31442207"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31442207"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Qiao Fan, Alfred Pozarickij, Nicholas Y Q Tan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association meta-analysis of corneal curvature identifies novel loci and shared genetic influences across axial length and refractive error."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Commun Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s42003-020-0802-y"}], "href": "https://doi.org/10.1038/s42003-020-0802-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32193507"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32193507"}]}]}]}