HMGN5 Gene

HGNC Family	High mobility group (HMG)
Name	high mobility group nucleosome binding domain 5
Description	This gene encodes a nuclear protein with similarities to the high mobility group proteins, HMG14 and HMG17, which suggests that this protein may function as a nucleosomal binding and transcriptional activating protein. [provided by RefSeq, Sep 2009]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n HMGN5, also referred to as NSBP1, is a member of the high‐mobility group nucleosome‐binding protein family that modulates chromatin architecture and influences gene transcription."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " By binding to nucleosomes, HMGN5 counteracts the chromatin‐compacting effects of linker histones, thereby promoting chromatin decompaction and altering nuclear mechanical properties."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}, {"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " This chromatin‐modifying activity is critical not only for the regulation of transcription across euchromatic regions but also for facilitating dynamic cellular processes.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Aberrant overexpression of HMGN5 has been implicated in the oncogenic progression of numerous malignancies. In several tumor types – including osteosarcoma (enhancing autophagy‐mediated chemoresistance and promoting cell cycle progression and invasive capacity)"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "6"}]}, {"type": "t", "text": ", bladder cancer (driving epithelial–mesenchymal transition and tumor aggressiveness)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ", clear cell renal cell carcinoma (supporting proliferation and invasion)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ", breast cancer (enhancing cell growth and metastatic potential)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ", as well as meningioma and esophageal squamous cell carcinoma (promoting tumor progression and resistance to chemotherapy)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "– HMGN5 appears to act as a potent oncogenic driver.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Mechanistically, HMGN5 exerts its oncogenic effects by regulating the expression of key cell cycle regulators (such as cyclin B1), anti‐apoptotic proteins (including Bcl-2), and matrix metalloproteinases, thereby stimulating cell proliferation, invasion, and chemoresistance. Furthermore, its expression is modulated by microRNAs – for instance, the targeting by miR-186 and miR-495 has been shown to suppress HMGN5 levels and inhibit tumorigenic behaviors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}, {"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Collectively, these findings underscore the dual role of HMGN5 as an architectural chromatin modulator and as an oncogenic factor, making it a promising potential target for therapeutic intervention in several cancers.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Cedric Malicet, Mark Rochman, Yuri Postnikov, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distinct properties of human HMGN5 reveal a rapidly evolving but functionally conserved nucleosome binding protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.05216-11"}], "href": "https://doi.org/10.1128/MCB.05216-11"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21518955"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21518955"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Takashi Furusawa, Mark Rochman, Leila Taher, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chromatin decompaction by the nucleosomal binding protein HMGN5 impairs nuclear sturdiness."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms7138"}], "href": "https://doi.org/10.1038/ncomms7138"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25609380"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25609380"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Mark Rochman, Yuri Postnikov, Sarah Correll, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The interaction of NSBP1/HMGN5 with nucleosomes in euchromatin counteracts linker histone-mediated chromatin compaction and modulates transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2009.07.002"}], "href": "https://doi.org/10.1016/j.molcel.2009.07.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19748358"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19748358"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yichen Meng, Rui Gao, Jun Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-140-5p regulates osteosarcoma chemoresistance by targeting HMGN5 and autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-017-00405-3"}], "href": "https://doi.org/10.1038/s41598-017-00405-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28341864"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28341864"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Chaoqun Yang, Rui Gao, Jirong Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High-mobility group nucleosome-binding domain 5 increases drug resistance in osteosarcoma through upregulating autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-014-1833-0"}], "href": "https://doi.org/10.1007/s13277-014-1833-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24664583"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24664583"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Weibo Jiang, Jia Zheng, Tao Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of microRNA-495 suppresses the proliferation and invasion and induces the apoptosis of osteosarcoma cells by targeting high-mobility group nucleosome-binding domain 5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2017.5715"}], "href": "https://doi.org/10.3892/or.2017.5715"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28627703"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28627703"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Kun Yao, Leye He, Yu Gan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-186 suppresses the growth and metastasis of bladder cancer by targeting NSBP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diagn Pathol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13000-015-0372-3"}], "href": "https://doi.org/10.1186/s13000-015-0372-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26290438"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26290438"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Shi-Qi Ji, Lin Yao, Xiao-Yu Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of the nucleosome binding protein 1 inhibits the growth and invasion of clear cell renal cell carcinoma cells in vitro and in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1756-9966-31-22"}], "href": "https://doi.org/10.1186/1756-9966-31-22"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22420896"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22420896"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Mingzhe Weng, Fangbin Song, Jinyu Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The high-mobility group nucleosome-binding domain 5 is highly expressed in breast cancer and promotes the proliferation and invasion of breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-014-2715-1"}], "href": "https://doi.org/10.1007/s13277-014-2715-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25315189"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25315189"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jing He, Chaoyang Liu, Bin Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HMGN5 blockade by siRNA enhances apoptosis, suppresses invasion and increases chemosensitivity to temozolomide in meningiomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2015.3131"}], "href": "https://doi.org/10.3892/ijo.2015.3131"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26315299"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26315299"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Xiaoping Liu, Weiping Ma, Yanli Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Silencing HMGN5 suppresses cell growth and promotes chemosensitivity in esophageal squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biochem Mol Toxicol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jbt.21996"}], "href": "https://doi.org/10.1002/jbt.21996"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28914995"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28914995"}]}]}]}
Synonyms	NBP-45, NSBP1
Proteins	HMGN5_HUMAN
NCBI Gene ID	79366
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

HMGN5 has 5,608 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 108 datasets.

Click the + buttons to view associations for HMGN5 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

HMGN5 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of HMGN5 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of HMGN5 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of HMGN5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of HMGN5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of HMGN5 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of HMGN5 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of HMGN5 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of HMGN5 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of HMGN5 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of HMGN5 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of HMGN5 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with HMGN5 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with HMGN5 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of HMGN5 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of HMGN5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of HMGN5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing HMGN5 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of HMGN5 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing HMGN5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing HMGN5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing HMGN5 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with HMGN5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with HMGN5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of HMGN5 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with HMGN5 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with HMGN5 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of HMGN5 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by HMGN5 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with HMGN5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with HMGN5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with HMGN5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with HMGN5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at HMGN5 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of HMGN5 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of HMGN5 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing HMGN5 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of HMGN5 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with HMGN5 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing HMGN5 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of HMGN5 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.