{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n HOATZ is a vertebrate‐specific protein that plays a critical role in the biogenesis of motile cilia and flagella. In studies using Hoatz knockout mice, loss of HOATZ led to hydrocephalus and male infertility, outcomes attributed to disorganized ependymal cilia and the collapse of developing spermatid flagella. Mechanistically, HOATZ associates with the flagellar glycolytic enzyme ENO4 and is required for its proper maturation; without HOATZ the immature form of ENO4 accumulates in abnormal cytoplasmic puncta. Although other investigations have focused on mechanisms underlying chromosomal rearrangements in leukemia"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "and amyloid‐β–dependent neurodegeneration with associated alterations in cilia functions"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", this work establishes that HOATZ is indispensable for proper ciliogenesis and flagellar assembly."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " These findings underscore that by mediating the maturation of key components required for the energy metabolism of motile structures, HOATZ is essential for maintaining the cellular functions that underpin both fluid movement in the brain and sperm motility.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "C Meyer, J Hofmann, T Burmeister, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The MLL recombinome of acute leukemias in 2013."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leukemia (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/leu.2013.135"}], "href": "https://doi.org/10.1038/leu.2013.135"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23628958"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23628958"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Srinivas V Koduru, Ashley N Leberfinger, Dino J Ravnic "}, {"type": "b", "children": [{"type": "t", "text": "Small Non-coding RNA Abundance in Adrenocortical Carcinoma: A Footprint of a Rare Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Genomics (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/jgen.22060"}], "href": "https://doi.org/10.7150/jgen.22060"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28943972"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28943972"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Teresa Ubina, Martha Magallanes, Saumya Srivastava, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Human Embryonic Stem Cell Model of Aβ-Dependent Chronic Progressive Neurodegeneration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Neurosci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fnins.2019.01007"}], "href": "https://doi.org/10.3389/fnins.2019.01007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31616241"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31616241"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Keishi Narita, Hiroaki Nagatomo, Hiroko Kozuka-Hata, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Discovery of a Vertebrate-Specific Factor that Processes Flagellar Glycolytic Enolase during Motile Ciliogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "iScience (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.isci.2020.100992"}], "href": "https://doi.org/10.1016/j.isci.2020.100992"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32248064"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32248064"}]}]}]}