| HGNC Family | Homeoboxes |
| Name | homeobox A1 |
| Description | In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. The encoded protein may be involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development. Two transcript variants encoding two different isoforms have been found for this gene, with only one of the isoforms containing the homeodomain region. [provided by RefSeq, Jul 2008] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nHOXA1 is a key homeobox transcription factor with seminal roles in early embryogenesis and patterning. In the developing hindbrain, HOXA1 (together with related paralogues) directs the formation and maintenance of segmental units and cranial neural crest‐derived structures, establishing regional identity and proper craniofacial morphogenesis. Moreover, germline truncating mutations and allelic variants in HOXA1 cause complex congenital disorders—such as Bosley–Salih–Alorainy and Athabascan brainstem dysgenesis syndromes—and have been linked to neurodevelopmental traits including abnormal head growth and autism features, partly through effects of polyhistidine repeat expansions that promote aberrant protein aggregation and toxicity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its developmental roles, HOXA1 exerts potent oncogenic functions in multiple epithelial cancers. Its aberrant expression promotes cell survival, proliferation, migration, and invasion through several signal‐transduction pathways—including the p44/42 MAPK, STAT, and NF‑κB cascades—and by upregulating prosurvival factors such as Bcl‑2. HOXA1’s oncogenic potential, which depends on critical domains (including a hexapeptide required for Pbx protein interaction), is further modulated by epigenetic regulators (e.g. histone demethylases and associated non‑coding RNAs) and targeted by tumor‑suppressor microRNAs. In various cancers such as those of the breast, prostate, liver, lung, and hematologic malignancies, HOXA1 is subject to regulation by competing endogenous RNAs (including lincRNAs like HOTAIRM1 and SNHG1, as well as circular RNAs) that ultimately influence chemoresistance and metastatic propensity. These oncogenic and regulatory mechanisms underscore the dual developmental and pathological roles played by HOXA1, highlighting its promise as both a prognostic biomarker and a therapeutic target."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "36"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "M Studer, A Gavalas, H Marshall, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic interactions between Hoxa1 and Hoxb1 reveal new roles in regulation of early hindbrain patterning."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (1998)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.125.6.1025"}], "href": "https://doi.org/10.1242/dev.125.6.1025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "9463349"}], "href": "https://pubmed.ncbi.nlm.nih.gov/9463349"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "J R Barrow, M R Capecchi "}, {"type": "b", "children": [{"type": "t", "text": "Compensatory defects associated with mutations in Hoxa1 restore normal palatogenesis to Hoxa2 mutants."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (1999)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.126.22.5011"}], "href": "https://doi.org/10.1242/dev.126.22.5011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "10529419"}], "href": "https://pubmed.ncbi.nlm.nih.gov/10529419"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jun Li, Holly K Tabor, Loan Nguyen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lack of association between HoxA1 and HoxB1 gene variants and autism in 110 multiplex families."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.1618"}], "href": "https://doi.org/10.1002/ajmg.1618"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11840501"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11840501"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Bernie Devlin, Pamela Bennett, Edwin H Cook, et al. "}, {"type": "b", "children": [{"type": "t", "text": "No evidence for linkage of liability to autism to HOXA1 in a sample from the CPEA network."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.10603"}], "href": "https://doi.org/10.1002/ajmg.10603"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12210285"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12210285"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Patricia M Rodier "}, {"type": "b", "children": [{"type": "t", "text": "Converging evidence for brain stem injury in autism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Psychopathol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1017/s0954579402003085"}], "href": "https://doi.org/10.1017/s0954579402003085"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12349873"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12349873"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Monica Conciatori, Christopher J Stodgell, Susan L Hyman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association between the HOXA1 A218G polymorphism and increased head circumference in patients with autism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Psychiatry (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopsych.2003.10.005"}], "href": "https://doi.org/10.1016/j.biopsych.2003.10.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14960295"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14960295"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Max A Tischfield, Thomas M Bosley, Mustafa A M Salih, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Homozygous HOXA1 mutations disrupt human brainstem, inner ear, cardiovascular and cognitive development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng1636"}], "href": "https://doi.org/10.1038/ng1636"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16155570"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16155570"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Rubigilda C Paraguison, Katsumi Higaki, Yumiko Sakamoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polyhistidine tract expansions in HOXA1 result in intranuclear aggregation and increased cell death."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2005.08.212"}], "href": "https://doi.org/10.1016/j.bbrc.2005.08.212"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16168961"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16168961"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "J Huntriss, M Hinkins, H M Picton "}, {"type": "b", "children": [{"type": "t", "text": "cDNA cloning and expression of the human NOBOX gene in oocytes and ovarian follicles."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Hum Reprod (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/molehr/gal035"}], "href": "https://doi.org/10.1093/molehr/gal035"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16597639"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16597639"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Rubigilda C Paraguison, Katsumi Higaki, Kenji Yamamoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Enhanced autophagic cell death in expanded polyhistidine variants of HOXA1 reduces PBX1-coupled transcriptional activity and inhibits neuronal differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci Res (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jnr.21137"}], "href": "https://doi.org/10.1002/jnr.21137"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17131398"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17131398"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Lucia Anna Muscarella, Vito Guarnieri, Roberto Sacco, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HOXA1 gene variants influence head growth rates in humans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet B Neuropsychiatr Genet (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.b.30469"}], "href": "https://doi.org/10.1002/ajmg.b.30469"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17171652"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17171652"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "T M Bosley, M A Salih, I A Alorainy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinical characterization of the HOXA1 syndrome BSAS variant."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurology (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1212/01.wnl.0000276947.59704.cf"}], "href": "https://doi.org/10.1212/01.wnl.0000276947.59704.cf"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17875913"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17875913"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Thomas M Bosley, Ibrahim A Alorainy, Mustafa A Salih, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The clinical spectrum of homozygous HOXA1 mutations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.32262"}], "href": "https://doi.org/10.1002/ajmg.a.32262"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18412118"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18412118"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Fabrice Laroche, Nicolas Ramoz, Sophie Leroy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polymorphisms of coding trinucleotide repeats of homeogenes in neurodevelopmental psychiatric disorders."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Psychiatr Genet (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/YPG.0b013e3283060fa5"}], "href": "https://doi.org/10.1097/YPG.0b013e3283060fa5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19018235"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19018235"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Xin Zhang, Tao Zhu, Yong Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human growth hormone-regulated HOXA1 is a human mammary epithelial oncogene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M212050200"}], "href": "https://doi.org/10.1074/jbc.M212050200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12482855"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12482855"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "K M Mohankumar, X Q Xu, T Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HOXA1-stimulated oncogenicity is mediated by selective upregulation of components of the p44/42 MAP kinase pathway in human mammary carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1210180"}], "href": "https://doi.org/10.1038/sj.onc.1210180"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17213808"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17213808"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Kumarasamypet M Mohankumar, Jo K Perry, Nagarajan Kannan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptional activation of signal transducer and activator of transcription (STAT) 3 and STAT5B partially mediate homeobox A1-stimulated oncogenic transformation of the immortalized human mammary epithelial cell."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/en.2007-1320"}], "href": "https://doi.org/10.1210/en.2007-1320"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18276758"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18276758"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Joan D Beckman, Chunseng Chen, Julia Nguyen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of heme oxygenase-1 protein expression by miR-377 in combination with miR-217."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.148726"}], "href": "https://doi.org/10.1074/jbc.M110.148726"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21106538"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21106538"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Stéphanie Delval, Arnaud Taminiau, Juliette Lamy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Pbx interaction motif of Hoxa1 is essential for its oncogenic activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0025247"}], "href": "https://doi.org/10.1371/journal.pone.0025247"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21957483"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21957483"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Tian-Zhou Zha, Ben-Shun Hu, Hai-Feng Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of HOXA1 correlates with poor prognosis in patients with hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-012-0472-6"}], "href": "https://doi.org/10.1007/s13277-012-0472-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22864671"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22864671"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Dan Chen, Zujian Chen, Yi Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-99 family members suppress Homeobox A1 expression in epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0080625"}], "href": "https://doi.org/10.1371/journal.pone.0080625"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24312487"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24312487"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Ming Liu, Shuangyun Zhao, Qingjie Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "YAP regulates the expression of Hoxa1 and Hoxc13 in mouse and human oral and skin epithelial tissues."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00765-14"}], "href": "https://doi.org/10.1128/MCB.00765-14"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25691658"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25691658"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Shun Fang, Hongyi Gao, Yue Tong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA-HOTAIR affects chemoresistance by regulating HOXA1 methylation in small cell lung cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Lab Invest (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/labinvest.2015.123"}], "href": "https://doi.org/10.1038/labinvest.2015.123"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26707824"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26707824"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Chenwei Yuan, Xingwu Zhu, Yang Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Elevated HOXA1 expression correlates with accelerated tumor cell proliferation and poor prognosis in gastric cancer partly via cyclin D1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-016-0294-2"}], "href": "https://doi.org/10.1186/s13046-016-0294-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26791264"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26791264"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Feng Xu, Li Liu, Chun-Kang Chang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genomic loss of EZH2 leads to epigenetic modifications and overexpression of the HOX gene clusters in myelodysplastic syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.6992"}], "href": "https://doi.org/10.18632/oncotarget.6992"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26812882"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26812882"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Arnaud Taminiau, Amandine Draime, Janne Tys, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HOXA1 binds RBCK1/HOIL-1 and TRAF2 and modulates the TNF/NF-κB pathway in a transcription-independent manner."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkw606"}], "href": "https://doi.org/10.1093/nar/gkw606"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27382069"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27382069"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Zhi-Qiang Ning, Hai-Lin Lu, Chao Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-30e reduces cell growth and enhances drug sensitivity to gefitinib in lung carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.13944"}], "href": "https://doi.org/10.18632/oncotarget.13944"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27992364"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27992364"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Xin Xu, Stefan Nagel, Hilmar Quentmeier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "KDM3B shows tumor-suppressive activity and transcriptionally regulates HOXA1 through retinoic acid response elements in acute myeloid leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leuk Lymphoma (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/10428194.2017.1324156"}], "href": "https://doi.org/10.1080/10428194.2017.1324156"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28540746"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28540746"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Yu Zhang, Xiao-Jiao Li, Rong-Quan He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of HOXA1 promotes tumorigenesis and development of non‑small cell lung cancer: A comprehensive investigation based on reverse transcription-quantitative polymerase chain reaction and bioinformatics analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2018.4372"}], "href": "https://doi.org/10.3892/ijo.2018.4372"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29658571"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29658571"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Feng Wang, Zhongqiong Tang, Honglian Shao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA HOTTIP cooperates with CCCTC-binding factor to coordinate HOXA gene expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.04.173"}], "href": "https://doi.org/10.1016/j.bbrc.2018.04.173"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29698677"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29698677"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Qi Li, Chengya Dong, Jiayue Cui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Over-expressed lncRNA HOTAIRM1 promotes tumor growth and invasion through up-regulating HOXA1 and sequestering G9a/EZH2/Dnmts away from the HOXA1 gene in glioblastoma multiforme."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-018-0941-x"}], "href": "https://doi.org/10.1186/s13046-018-0941-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30376874"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30376874"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "J-J Zheng, X-J Du, H-P Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA 00152 promotes cell proliferation in cervical cancer via regulating miR-216b-5p/HOXA1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201905_17789"}], "href": "https://doi.org/10.26355/eurrev_201905_17789"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31114990"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31114990"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Zhiyang Han, Yinghui Guan, Bing Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-99a-5p alleviates atherosclerosis via regulating Homeobox A1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Life Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.lfs.2019.116664"}], "href": "https://doi.org/10.1016/j.lfs.2019.116664"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31325426"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31325426"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Jun Li, Tianyu Zeng, Wei Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA SNHG1 activates HOXA1 expression via sponging miR-193a-5p in breast cancer progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.103123"}], "href": "https://doi.org/10.18632/aging.103123"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32497022"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32497022"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Bal Krishna Chand Thakuri, Jinyu Zhang, Juan Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA HOTAIRM1 promotes MDSC expansion and suppressive functions through the HOXA1-miR124 axis during HCV infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-020-78786-1"}], "href": "https://doi.org/10.1038/s41598-020-78786-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33328510"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33328510"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Wei Zhong, Lei Bao, Yangyi Yuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CircRASSF2 acts as a prognostic factor and promotes breast cancer progression by modulating miR-1205/HOXA1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1933300"}], "href": "https://doi.org/10.1080/21655979.2021.1933300"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34180753"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34180753"}]}]}]}
|
| Synonyms | HOX1F, BSAS |
| Proteins | HXA1_HUMAN |
| NCBI Gene ID | 3198 |
| API | |
| Download Associations | |
| Predicted Functions |
 |
| Co-expressed Genes |
|
| Expression in Tissues and Cell Lines |
|
HOXA1 has 5,771 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 108 datasets.
Click the + buttons to view associations for HOXA1 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of HOXA1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of HOXA1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of HOXA1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of HOXA1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of HOXA1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| Carcinogenome Chemical Perturbation Carcinogenicity Signatures | small molecule perturbations changing expression of HOXA1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of HOXA1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of HOXA1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with HOXA1 gene from the CellMarker Gene-Cell Type Associations dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of HOXA1 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of HOXA1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of HOXA1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| ClinVar Gene-Phenotype Associations 2025 | phenotypes associated with HOXA1 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset. | |
| CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of HOXA1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing HOXA1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing HOXA1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with HOXA1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with HOXA1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of HOXA1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with HOXA1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| CTD Gene-Chemical Interactions | chemicals interacting with HOXA1 gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
| CTD Gene-Disease Associations | diseases associated with HOXA1 gene/protein from the curated CTD Gene-Disease Associations dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by HOXA1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with HOXA1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with HOXA1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with HOXA1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with HOXA1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with HOXA1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at HOXA1 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of HOXA1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of HOXA1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing HOXA1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GAD Gene-Disease Associations | diseases associated with HOXA1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
| GAD High Level Gene-Disease Associations | diseases associated with HOXA1 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
| GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of HOXA1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with HOXA1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing HOXA1 from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of HOXA1 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of HOXA1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of HOXA1 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of HOXA1 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of HOXA1 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of HOXA1 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving HOXA1 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving HOXA1 gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving HOXA1 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing HOXA1 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Cellular Component Annotations 2023 | cellular components containing HOXA1 protein from the curated GO Cellular Component Annotations 2023 dataset. | |
| GO Cellular Component Annotations 2025 | cellular components containing HOXA1 protein from the curated GO Cellular Component Annotations 2025 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by HOXA1 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by HOXA1 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by HOXA1 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx eQTL 2025 | SNPs regulating expression of HOXA1 gene from the GTEx eQTL 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of HOXA1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of HOXA1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of HOXA1 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of HOXA1 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with HOXA1 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of HOXA1 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of HOXA1 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of HOXA1 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of HOXA1 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of HOXA1 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
| HPO Gene-Disease Associations | phenotypes associated with HOXA1 gene by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset. | |
| Hub Proteins Protein-Protein Interactions | interacting hub proteins for HOXA1 from the curated Hub Proteins Protein-Protein Interactions dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with HOXA1 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for HOXA1 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of HOXA1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of HOXA1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of HOXA1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| KEGG Pathways 2026 | pathways involving HOXA1 protein from the KEGG Pathways 2026 dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of HOXA1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with HOXA1 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of HOXA1 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of HOXA1 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of HOXA1 gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
| LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of HOXA1 gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| LOCATE Curated Protein Localization Annotations | cellular components containing HOXA1 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain HOXA1 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by HOXA1 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
| MiRTarBase microRNA Targets | microRNAs targeting HOXA1 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of HOXA1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| MPO Gene-Phenotype Associations | phenotypes of transgenic mice caused by HOXA1 gene mutations from the MPO Gene-Phenotype Associations dataset. | |
| MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of HOXA1 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
| NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of HOXA1 gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
| OMIM Gene-Disease Associations | phenotypes associated with HOXA1 gene from the curated OMIM Gene-Disease Associations dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for HOXA1 from the Pathway Commons Protein-Protein Interactions dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of HOXA1 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of HOXA1 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PFOCR Pathway Figure Associations 2023 | pathways involving HOXA1 protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving HOXA1 protein from the Wikipathways PFOCR 2024 dataset. | |
| Reactome Pathways 2024 | pathways involving HOXA1 protein from the Reactome Pathways 2024 dataset. | |
| Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of HOXA1 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at HOXA1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of HOXA1 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of HOXA1 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of HOXA1 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
| TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of HOXA1 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of HOXA1 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of HOXA1 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of HOXA1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of HOXA1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of HOXA1 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of HOXA1 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with HOXA1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with HOXA1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
| WikiPathways Pathways 2014 | pathways involving HOXA1 protein from the Wikipathways Pathways 2014 dataset. | |
| WikiPathways Pathways 2024 | pathways involving HOXA1 protein from the WikiPathways Pathways 2024 dataset. | |
