HOXA11-AS Gene

HGNC Family Non-coding RNAs
Name HOXA11 antisense RNA
Description This gene produces a long non-coding RNA in antisense to transcription of the homeobox A11 gene. This transcript may associate with chromatin factors such as Polycomb repressive complex and act as a sponge for microRNAs, thereby participating in the regulation of expression of target genes. High levels of this transcript may be associated with tumor progression. [provided by RefSeq, Dec 2017]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n HOXA11‐AS is a long non‐coding RNA whose dysregulated expression plays a multifaceted role in cancer. In several malignancies – including gastric cancer, cervical cancer, glioma, breast cancer, oral squamous cell carcinoma, renal cancer, non‐small cell lung cancer, liver cancer, and others – HOXA11‐AS is aberrantly upregulated and acts in an oncogenic fashion by promoting cell proliferation, migration, invasion, epithelial–mesenchymal transition (EMT), chemoresistance, and cancer stemness while inhibiting apoptosis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Mechanistically, HOXA11‐AS can serve as a molecular scaffold that recruits chromatin‐modifying factors (such as EZH2, LSD1, DNMT1, and others) to regulate gene transcription, including repressing tumor‐suppressive genes (e.g., p21) and activating oncogenes (e.g., β‐catenin)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, HOXA11‐AS acts as a competing endogenous RNA (ceRNA) by sponging various microRNAs (for instance, miR‐1297, miR‐214‐3p, miR‐454‐3p, miR‐146b‐5p, miR‐124, and miR‐15a‐3p), which results in the de‐repression of downstream targets such as EZH2, STAT3, Sp1, PIM1, and MMP16 – key effectors that contribute to the malignant phenotypes observed in these tumors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}, {"type": "fg_f", "ref": "5"}, {"type": "fg_f", "ref": "7"}, {"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Notably, while the majority of studies report an oncogenic role for HOXA11‐AS, its function may be context dependent. For example, in epithelial ovarian cancer, lower expression of HOXA11‐AS and a specific genetic variant are associated with tumor‐suppressive effects, suggesting that HOXA11‐AS may also exhibit tumor‐inhibitory properties in certain contexts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these findings reveal that HOXA11‐AS is a critical regulator in cancer progression whose dual molecular functions – as a scaffold for epigenetic modifiers and as a ceRNA – modulate key signaling pathways and effector genes, highlighting its potential as both a prognostic biomarker and a therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ming Sun, Fengqi Nie, Yunfei Wang, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Regulation of HOXA11-AS/miR-214-3p/EZH2 axis on the growth, migration and invasion of glioma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2017.08.097"}], "href": "https://doi.org/10.1016/j.biopha.2017.08.097"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28946213"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28946213"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Wenlei Li, Guotao Jia, Yanwen Qu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Non-Coding RNA (LncRNA) HOXA11-AS Promotes Breast Cancer Invasion and Metastasis by Regulating Epithelial-Mesenchymal Transition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Sci Monit (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12659/msm.904892"}], "href": "https://doi.org/10.12659/msm.904892"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28701685"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28701685"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Xiaoyan Wang, Hong Li, Jing Shi "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA HOXA11-AS Promotes Proliferation and Cisplatin Resistance of Oral Squamous Cell Carcinoma by Suppression of miR-214-3p Expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2019/8645153"}], "href": "https://doi.org/10.1155/2019/8645153"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31275988"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31275988"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Feng-Qiang Yang, Jian-Qiu Zhang, Jiang-Jiang Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HOXA11-AS promotes the growth and invasion of renal cancer by sponging miR-146b-5p to upregulate MMP16 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.26864"}], "href": "https://doi.org/10.1002/jcp.26864"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29953617"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29953617"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Wanjun Yu, Weidong Peng, Hao Jiang, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "The lncRNA HOXA11-AS promotes glioma cell growth and metastasis by targeting miR-130a-5p/HMGB2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201901_16770"}], "href": "https://doi.org/10.26355/eurrev_201901_16770"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30657566"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30657566"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Edward J Richards, Jennifer Permuth-Wey, Yajuan Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A functional variant in HOXA11-AS, a novel long non-coding RNA, inhibits the oncogenic phenotype of epithelial ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.5784"}], "href": "https://doi.org/10.18632/oncotarget.5784"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26430965"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26430965"}]}]}]}
Synonyms HOXA11AS, HOXA11S, HOXA11-AS1, HOXA-AS5, NCRNA00076
NCBI Gene ID 221883
API
Download Associations
Predicted Functions View HOXA11-AS's ARCHS4 Predicted Functions.
Co-expressed Genes View HOXA11-AS's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View HOXA11-AS's ARCHS4 Predicted Functions.

Functional Associations

HOXA11-AS has 1,101 functional associations with biological entities spanning 7 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 24 datasets.

Click the + buttons to view associations for HOXA11-AS from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of HOXA11-AS gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
CCLE Cell Line Gene Expression Profiles cell lines with high or low expression of HOXA11-AS gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of HOXA11-AS gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of HOXA11-AS gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of HOXA11-AS gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at HOXA11-AS gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of HOXA11-AS gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of HOXA11-AS gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells PubMedIDs of publications reporting gene signatures containing HOXA11-AS from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing HOXA11-AS from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Diseases disease perturbations changing expression of HOXA11-AS gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of HOXA11-AS gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of HOXA11-AS gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations transcription factor perturbations changing expression of HOXA11-AS gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Viral Infections virus perturbations changing expression of HOXA11-AS gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of HOXA11-AS gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
GWASdb SNP-Disease Associations diseases associated with HOXA11-AS gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.
GWASdb SNP-Phenotype Associations phenotypes associated with HOXA11-AS gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of HOXA11-AS gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of HOXA11-AS gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of HOXA11-AS gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles cell types and tissues with high or low DNA methylation of HOXA11-AS gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at HOXA11-AS gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
TCGA Signatures of Differentially Expressed Genes for Tumors tissue samples with high or low expression of HOXA11-AS gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.