{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long noncoding RNA HOXB‐AS1 has emerged as an oncogenic regulator in several cancer types, exerting its function through diverse molecular mechanisms. In multiple myeloma, HOXB‐AS1 is highly expressed and promotes cell proliferation while inhibiting apoptosis through stabilization of FUT4 mRNA via enhanced interaction with ELAVL1. This, in turn, activates FUT4‐mediated Wnt/β‐catenin signaling, highlighting its potential as a therapeutic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In glioblastoma, HOXB‐AS1 not only facilitates tumor growth by recruiting ILF3 to upregulate the transcription of neighboring HOXB2 and HOXB3, but also acts in the cytoplasm as a competing endogenous RNA (ceRNA) that sponges miR‐885-3p, thereby modulating HOXB2 expression. These complementary mechanisms underscore its importance in glioblastoma progression"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ";."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, HOXB‐AS1 appears in prognostic panels for various tumors. In thymic epithelial tumors, it is one of several immune‐related lncRNAs whose differential expression helps classify patient risk and correlate with immune cell infiltration and immunotherapy response"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", while in triple‐negative breast cancer its altered expression contributes to a prognostic risk model."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Pan‐cancer analyses further suggest that HOXB‐AS1 is linked not only to oncogenesis but also to the modulation of the tumor immune microenvironment, being significantly upregulated in more aggressive cancers such as glioblastoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In endometrial carcinoma, upregulated HOXB‐AS1 is associated with poor patient survival and enhanced tumor aggressiveness. Functioning as a ceRNA, it sponges miR‐149-3p, leading to increased Wnt10b expression and subsequent activation of the β‐catenin signaling pathway, thereby promoting proliferation, invasion, and migration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies demonstrate that HOXB‐AS1 regulates key oncogenic pathways through both transcriptional and posttranscriptional mechanisms, making it a promising diagnostic and therapeutic target across multiple tumor types.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Rongsheng Chen, Xiaobo Zhang, Changsheng Wang "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA HOXB-AS1 promotes cell growth in multiple myeloma via FUT4 mRNA stability by ELAVL1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.29573"}], "href": "https://doi.org/10.1002/jcb.29573"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31886581"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31886581"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yongyan Bi, Yuhang Mao, Zuopeng Su, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HOXB-AS1 accelerates the tumorigenesis of glioblastoma via modulation of HOBX2 and HOBX3 at transcriptional and posttranscriptional levels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.29499"}], "href": "https://doi.org/10.1002/jcp.29499"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33459377"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33459377"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "X Chen, L Q Li, X Qiu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA HOXB-AS1 promotes proliferation, migration and invasion of glioblastoma cells via HOXB-AS1/miR-885-3p/HOXB2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasma (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4149/neo_2018_180606N377"}], "href": "https://doi.org/10.4149/neo_2018_180606N377"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30784279"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30784279"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yongchao Su, Yangpeng Ou, Yongbing Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Construction of immune-related LncRNAs classifier to predict prognosis and immunotherapy response in thymic epithelial tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20220317"}], "href": "https://doi.org/10.1042/BSR20220317"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35438133"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35438133"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jie Wu, Yan Cai, Gaiping Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A ten N6-methyladenosine-related long non-coding RNAs signature predicts prognosis of triple-negative breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Lab Anal (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcla.23779"}], "href": "https://doi.org/10.1002/jcla.23779"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33934391"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33934391"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Wei Shao, Qian Ding, Yugang Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Pan-Cancer Landscape of HOX-Related lncRNAs and Their Association With Prognosis and Tumor Microenvironment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Mol Biosci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fmolb.2021.767856"}], "href": "https://doi.org/10.3389/fmolb.2021.767856"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34805277"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34805277"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Da Liu, Min Qiu, Lili Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA HOXB-AS1 Is Upregulated in Endometrial Carcinoma and Sponged miR-149-3p to Upregulate Wnt10b."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Technol Cancer Res Treat (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1533033820967462"}], "href": "https://doi.org/10.1177/1533033820967462"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33073693"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33073693"}]}]}]}