{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n HOXB‐AS2 is a long non‐coding RNA that appears to play multifaceted roles in distinct disease contexts. In ovarian cancer, HOXB‐AS2 was identified as one of seven immune‐related lncRNAs whose differential expression can serve as an independent prognostic factor. Within this context, the lncRNA signature—including HOXB‐AS2—not only stratified patients into high‐ and low‐risk groups based on survival outcomes but also highlighted potential immune regulatory mechanisms that could impact tumor behavior."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Conversely, in the setting of atrial fibrillation, HOXB‐AS2, together with other HOX cluster antisense transcripts, was found to be significantly downregulated in epicardial adipose tissues. This downregulation suggests that HOXB‐AS2 may be involved in modulating inflammatory pathways, such as those linked to TNF signaling, thereby contributing to the molecular pathogenesis of atrial fibrillation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xue Pan, Fangfang Bi "}, {"type": "b", "children": [{"type": "t", "text": "A Potential Immune-Related Long Non-coding RNA Prognostic Signature for Ovarian Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2021.694009"}], "href": "https://doi.org/10.3389/fgene.2021.694009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34367253"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34367253"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xin Shi, Xuelian Shao, Ban Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide screening of functional long noncoding RNAs in the epicardial adipose tissues of atrial fibrillation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta Mol Basis Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbadis.2020.165757"}], "href": "https://doi.org/10.1016/j.bbadis.2020.165757"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32147422"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32147422"}]}]}]}