{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Among the long noncoding RNAs featured in these studies, HOXB‐AS4 was identified in pancreatic cancer as a gene displaying cancer‐specific DNA methylation. In a genome‐wide methylation screening of pancreatic neoplasms, HOXB‐AS4 was one of four loci—including SIM1, MIR129‐2, and NR1I2—that showed hypermethylation exclusively in cancer cells relative to noncancerous tissues. This cancer‐specific methylation underscores its potential utility as a biomarker for estimating the pancreatic cancer cell fraction in mixed DNA samples, thereby facilitating more precise molecular analyses of tumor specimens."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hiroki Ishihara, Satoshi Yamashita, Ryosuke Amano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pancreatic Cancer Cell Fraction Estimation in a DNA Sample."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncology (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000491637"}], "href": "https://doi.org/10.1159/000491637"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30149376"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30149376"}]}]}]}