{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n HOXC‐AS1 is a long noncoding RNA with context‐dependent functions in diverse diseases. In atherosclerosis, HOXC‐AS1 is downregulated in carotid plaques, and its overexpression in macrophages increases HOXC6 expression and mitigates oxidized LDL‐induced cholesterol accumulation, suggesting a protective role in regulating lipid homeostasis and plaque stability."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In castration‐resistant prostate cancer, HOXC‐AS1 is an androgen receptor–regulated transcript whose silencing decreases tumor growth by repressing both full‐length and variant AR expression, likely through modulation of splicing factor distribution."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In gastric cancer, multiple studies have demonstrated that HOXC‐AS1 is upregulated and functions as an oncogene: it promotes cell proliferation, epithelial–mesenchymal transition, and metastasis. Mechanistically, HOXC‐AS1 is trans‐activated by c‐MYC and establishes a positive feedback loop that upregulates MYC via both cytoplasmic (targeting the miR‐590-3p/MYC axis) and nuclear (modulating the BRG1/β-catenin complex) mechanisms, and it also interacts with eIF4AIII to regulate Wnt/β-catenin signaling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "5"}]}, {"type": "t", "text": " Moreover, in nasopharyngeal carcinoma, HOXC‐AS1 enhances tumor progression by sponging miR-4651 to regulate FOXO6 expression, thereby promoting cell proliferation, migration, and invasion while inhibiting apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Taken together, these findings indicate that HOXC‐AS1 plays multifaceted roles in both tumorigenesis and cardiovascular disease, highlighting its potential as a biomarker and therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chuan Huang, Yan-Wei Hu, Jing-Jing Zhao, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "HOXC-AS1-MYC regulatory loop contributes to the growth and metastasis in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-019-1482-7"}], "href": "https://doi.org/10.1186/s13046-019-1482-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31870402"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31870402"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Chao Zhou, Na An, Chunyan Cao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA HOXC-AS1 promotes gastric cancer via binding eIF4AIII by activating Wnt/β-catenin signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gene Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jgm.3202"}], "href": "https://doi.org/10.1002/jgm.3202"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32307743"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32307743"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Shumin Zhang, Lianzhen Wang, Yuting Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular Mechanism of 73HOXC-AS1-Activated Wnt"}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "β"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "-Catenin Signaling and eIF4AIII in Promoting Progression of Gastric Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2021/8814843"}], "href": "https://doi.org/10.1155/2021/8814843"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33954199"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33954199"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Zhiyuan Tang, Xianhai Zeng, Juanjuan Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA HOXC-AS1 promotes nasopharyngeal carcinoma (NPC) progression by sponging miR-4651 and subsequently upregulating FOXO6."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Pharmacol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jphs.2021.08.002"}], "href": "https://doi.org/10.1016/j.jphs.2021.08.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34507637"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34507637"}]}]}]}