{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In several cancers, the long non‐coding RNA HOXC‑AS2 has emerged as an important regulatory molecule that modulates tumor progression by affecting cellular proliferation, migration, epithelial–mesenchymal transition (EMT) and cell death pathways. In non‐small cell lung cancer, HOXC‑AS2 is significantly upregulated and promotes tumor growth and metastasis by reciprocally regulating HOXC13, thereby enhancing cell proliferation, migration and EMT while inhibiting apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In glioma, elevated HOXC‑AS2 facilitates malignant progression by sponging miR‑876‑5p, which leads to increased ZEB1 expression and in turn promotes migration, invasion and EMT."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In high‑glucose–related endometrial cancer, HOXC‑AS2 is implicated in the regulation of cell pyroptosis by modulating the miR‑876‑5p/HKDC1 axis; this action contributes to an altered inflammatory tumor microenvironment that favors disease progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Additionally, HOXC‑AS2 has been identified as a potential diagnostic biomarker in gastric adenocarcinoma, possibly acting in cis to regulate a cluster of HOX genes that may influence tumor behavior."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings indicate that HOXC‑AS2 plays multifaceted roles in oncogenesis by interfacing with critical signaling pathways and molecular targets across diverse tumor types, highlighting its potential both as a therapeutic target and as a biomarker for cancer diagnosis.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Bin Liu, Jing Li, Ji-Man Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HOXC-AS2 mediates the proliferation, apoptosis, and migration of non-small cell lung cancer by combining with HOXC13 gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2020.1868161"}], "href": "https://doi.org/10.1080/15384101.2020.1868161"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33427025"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33427025"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Nan Dong, Junxiu Guo, Song Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Positive feedback loop of lncRNA HOXC-AS2/miR-876-5p/ZEB1 to regulate EMT in glioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Onco Targets Ther (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/OTT.S216134"}], "href": "https://doi.org/10.2147/OTT.S216134"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31571911"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31571911"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jing Guo, Feng Ye, Wenli Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The HOXC-AS2/miR-876-5p/HKDC1 axis regulates endometrial cancer progression in a high glucose-related tumor microenvironment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.15384"}], "href": "https://doi.org/10.1111/cas.15384"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35485648"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35485648"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Tao Fu, Xin Ji, Zhaode Bu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of key long non-coding RNAs in gastric adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biomark (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/CBM-192389"}], "href": "https://doi.org/10.3233/CBM-192389"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32176636"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32176636"}]}]}]}