{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n HPN‐AS1 is a long noncoding RNA that has emerged as a potential prognostic biomarker in several cancer contexts. In hepatocellular carcinoma, HPN‐AS1 is one of eight lncRNAs whose expression levels were integrated into a prognostic scoring model that correlated with tumor mutation burden and immune infiltration, indicating that its dysregulation may influence tumor behavior and patient outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, in hormone‐related cancers, HPN‐AS1 was identified as an androgen‐responsive lncRNA with prognostic value, suggesting involvement in signaling pathways that modulate oncogenesis and disease progression (3). Its inclusion among the set of genes used in a transcriptome‐based diagnostic model for prostate cancer further supports its potential utility as a biomarker for disease classification."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Although the study examining lipid traits in type 2 diabetes"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "does not directly address HPN‐AS1 function, the cumulative evidence across these studies underscores HPN‐AS1’s emerging role in cancer prognosis and possibly in the regulation of tumorigenic pathways.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Feng Qi, Xiaojing Du, Zhiying Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor Mutation Burden-Associated LINC00638/miR-4732-3p/ULBP1 Axis Promotes Immune Escape "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "via"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " PD-L1 in Hepatocellular Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2021.729340"}], "href": "https://doi.org/10.3389/fonc.2021.729340"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34568062"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34568062"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Dan Wang, Mingyue Li, Jing Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive Characterization of Androgen-Responsive lncRNAs Mediated Regulatory Network in Hormone-Related Cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dis Markers (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2020/8884450"}], "href": "https://doi.org/10.1155/2020/8884450"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33082888"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33082888"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jason B Nikas, Nikos T Mitanis, Emily G Nikas "}, {"type": "b", "children": [{"type": "t", "text": "Whole Exome and Transcriptome RNA-Sequencing Model for the Diagnosis of Prostate Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "ACS Omega (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/acsomega.9b02995"}], "href": "https://doi.org/10.1021/acsomega.9b02995"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31956794"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31956794"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Skylar W Marvel, Daniel M Rotroff, Michael J Wagner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Common and rare genetic markers of lipid variation in subjects with type 2 diabetes from the ACCORD clinical trial."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PeerJ (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7717/peerj.3187"}], "href": "https://doi.org/10.7717/peerj.3187"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28480134"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28480134"}]}]}]}