HPSE Gene

Name	heparanase
Description	Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. The protein encoded by this gene is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through remodeling of the extracellular matrix. In addition, this cleavage can release bioactive molecules from the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Heparanase (HPSE) is a unique mammalian endoglycosidase that degrades heparan sulfate (HS) side chains on proteoglycans, thereby remodeling the extracellular matrix and basement membranes. This enzymatic activity facilitates the penetration of cells through dense stroma, as evidenced by its ability to improve the infiltration of engineered T lymphocytes into solid tumors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In transgenic mouse models, heightened HPSE expression not only alters HS chain size but also impacts tissue morphogenesis, vascularization, and even hair follicle branching, indicating a broader role in tissue remodeling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In cancer, HPSE promotes tumor growth, metastasis, and angiogenesis by degrading HS within the tumor microenvironment; for instance, in multiple myeloma HPSE activity enhances syndecan-1 shedding and stimulates the release of exosomes that support chemoresistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Furthermore, numerous reviews have underscored HPSE’s central role in modulating oncogenic processes, inflammation, and chemoresistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In nonmalignant conditions, such as diabetic nephropathy, increased HPSE expression is linked to the degradation of HS in the glomerular basement membrane, which contributes to proteinuria and impaired kidney function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Studies using HPSE knockout mice reveal that loss of HPSE activity leads to the accumulation of long HS chains and triggers compensatory upregulation of matrix metalloproteinases, underscoring its role in regulating matrix dynamics."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Moreover, HPSE has been implicated in the regulation of autophagy in tumor cells, contributing to cellular stress resistance and diminished responsiveness to chemotherapy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " In breast cancer, increased HPSE expression correlates with decreased HS deposition and elevated metastatic potential"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ", and atomic-level structural studies have detailed the organization of its substrate-binding cleft, paving the way for rational inhibitor design."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " At the transcriptional level, HPSE expression is intricately regulated; for example, microRNA-558 binds directly to a site within the HPSE promoter to upregulate its transcription in neuroblastoma, while transcription factors such as EGR1 modulate its inducible expression in both T cells and various tumor cell types."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "14"}]}, {"type": "t", "text": " Finally, emerging evidence points to a nuclear role for HPSE in modulating gene transcription and T cell differentiation, as well as in altering the survival of insulin‐producing cells in autoimmune diabetes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": " Collectively, these findings establish HPSE as a pivotal mediator of extracellular matrix remodeling with far‐reaching effects on tumor progression, metastasis, angiogenesis, chemoresistance, and pathological alterations in nonmalignant diseases.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ignazio Caruana, Barbara Savoldo, Valentina Hoyos, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm.3833"}], "href": "https://doi.org/10.1038/nm.3833"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25849134"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25849134"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Eyal Zcharia, Shula Metzger, Tova Chajek-Shaul, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transgenic expression of mammalian heparanase uncovers physiological functions of heparan sulfate in tissue morphogenesis, vascularization, and feeding behavior."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.03-0572com"}], "href": "https://doi.org/10.1096/fj.03-0572com"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14769819"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14769819"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Joseph P Ritchie, Vishnu C Ramani, Yongsheng Ren, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SST0001, a chemically modified heparin, inhibits myeloma growth and angiogenesis via disruption of the heparanase/syndecan-1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-10-2476"}], "href": "https://doi.org/10.1158/1078-0432.CCR-10-2476"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21257720"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21257720"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Shyam K Bandari, Anurag Purushothaman, Vishnu C Ramani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chemotherapy induces secretion of exosomes loaded with heparanase that degrades extracellular matrix and impacts tumor and host cell behavior."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Matrix Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.matbio.2017.09.001"}], "href": "https://doi.org/10.1016/j.matbio.2017.09.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28888912"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28888912"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Ralph D Sanderson, Michael Elkin, Alan C Rapraeger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Heparanase regulation of cancer, autophagy and inflammation: new mechanisms and targets for therapy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS J (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/febs.13932"}], "href": "https://doi.org/10.1111/febs.13932"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27758044"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27758044"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Natali Gil, Rachel Goldberg, Tzahi Neuman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Heparanase is essential for the development of diabetic nephropathy in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2337/db11-1024"}], "href": "https://doi.org/10.2337/db11-1024"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22106160"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22106160"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Justin B Maxhimer, Michael Somenek, Geetha Rao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Heparanase-1 gene expression and regulation by high glucose in renal epithelial cells: a potential role in the pathogenesis of proteinuria in diabetic patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2337/diabetes.54.7.2172"}], "href": "https://doi.org/10.2337/diabetes.54.7.2172"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15983219"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15983219"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Eyal Zcharia, Juan Jia, Xiao Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Newly generated heparanase knock-out mice unravel co-regulation of heparanase and matrix metalloproteinases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0005181"}], "href": "https://doi.org/10.1371/journal.pone.0005181"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19360105"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19360105"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Anna Shteingauz, Ilanit Boyango, Inna Naroditsky, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Heparanase Enhances Tumor Growth and Chemoresistance by Promoting Autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-15-0037"}], "href": "https://doi.org/10.1158/0008-5472.CAN-15-0037"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26249176"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26249176"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Justin B Maxhimer, Roderick M Quiros, Robyn Stewart, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Heparanase-1 expression is associated with the metastatic potential of breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Surgery (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1067/msy.2002.125719"}], "href": "https://doi.org/10.1067/msy.2002.125719"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12219030"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12219030"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Liang Wu, Cristina M Viola, Andrzej M Brzozowski, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural characterization of human heparanase reveals insights into substrate recognition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nsmb.3136"}], "href": "https://doi.org/10.1038/nsmb.3136"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26575439"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26575439"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Hongxia Qu, Liduan Zheng, Jiarui Pu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miRNA-558 promotes tumorigenesis and aggressiveness of neuroblastoma cells through activating the transcription of heparanase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddv018"}], "href": "https://doi.org/10.1093/hmg/ddv018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25616966"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25616966"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Amanda M de Mestre, Sudha Rao, June R Hornby, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Early growth response gene 1 (EGR1) regulates heparanase gene transcription in tumor cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M503414200"}], "href": "https://doi.org/10.1074/jbc.M503414200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16093249"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16093249"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Amanda M de Mestre, Levon M Khachigian, Fernando S Santiago, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of inducible heparanase gene transcription in activated T cells by early growth response 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M310154200"}], "href": "https://doi.org/10.1074/jbc.M310154200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14522979"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14522979"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "C R Parish, C Freeman, A F Ziolkowski, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Unexpected new roles for heparanase in Type 1 diabetes and immune gene regulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Matrix Biol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.matbio.2013.02.007"}], "href": "https://doi.org/10.1016/j.matbio.2013.02.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23499527"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23499527"}]}]}]}
Synonyms	HSE1, HPA, HPA1, HPSE1
Proteins	HPSE_HUMAN
NCBI Gene ID	10855
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

HPSE has 8,858 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 126 datasets.

Click the + buttons to view associations for HPSE from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

HPSE Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of HPSE gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of HPSE gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of HPSE gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of HPSE gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of HPSE gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of HPSE gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of HPSE gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of HPSE gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of HPSE gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of HPSE gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of HPSE gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of HPSE gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with HPSE protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with HPSE gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of HPSE gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of HPSE gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of HPSE gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing HPSE protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of HPSE gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing HPSE protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing HPSE protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing HPSE protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with HPSE protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with HPSE protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with HPSE gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with HPSE gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with HPSE gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of HPSE protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by HPSE gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with HPSE gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with HPSE gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with HPSE gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with HPSE gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with HPSE gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for HPSE protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at HPSE gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of HPSE gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of HPSE gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing HPSE from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with HPSE gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.