| Name | human papillomavirus (type 18) E5 central sequence-like 1 |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n HPVC1 has recently emerged as a candidate gene implicated in the etiology of chronic periodontitis. Genome‐wide association studies have identified significant signals for HPVC1 in analyses of periodontal complex traits (PCTs)—specifically, a distinctive trait (PCT4) that may reflect alterations in the local inflammatory milieu and epithelial barrier function. These findings suggest that HPVC1 could play a role in modulating the host’s immune response to microbial dysbiosis, thereby influencing the progression and clinical features of periodontal disease. Replication studies have further supported the association of HPVC1 with periodontitis‐related clinical measures, including increased periodontal pocket depths, underscoring its potential as a biological marker for disease severity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Steven Offenbacher, Kimon Divaris, Silvana P Barros, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study of biologically informed periodontal complex traits offers novel insights into the genetic basis of periodontal disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddw069"}], "href": "https://doi.org/10.1093/hmg/ddw069"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26962152"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26962152"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Teresa Yang, Bin Cheng, James M Noble, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Replication of gene polymorphisms associated with periodontitis-related traits in an elderly cohort: the Washington Heights/Inwood Community Aging Project Ancillary Study of Oral Health."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Periodontol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcpe.13605"}], "href": "https://doi.org/10.1111/jcpe.13605"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35179257"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35179257"}]}]}]}
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| Synonyms | PE5L, HPV18E5L |
| NCBI Gene ID | 3262 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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HPVC1 has 397 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 12 datasets.
Click the + buttons to view associations for HPVC1 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of HPVC1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of HPVC1 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of HPVC1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of HPVC1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at HPVC1 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of HPVC1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of HPVC1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of HPVC1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of HPVC1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of HPVC1 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of HPVC1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of HPVC1 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
