{"type": "root", "children": [{"type": "t", "text": "<head>\n <meta charset=\"UTF-8\">\n <title>HS1BP3-IT1 Function Summary</title>\n </head>\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the abstract by Goldberger et al"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", the primary focus is on identifying parent‐of‐origin effects on adiposity and glycemic traits – notably, a maternal‐specific association of a common variant in "}, {"type": "i", "children": [{"type": "t", "text": "APOB"}]}, {"type": "t", "text": " with body mass index, waist circumference, and glycemic measures. The study details regulatory annotations that point to tissue‐specific effects (with evidence of allelic‐specific methylation in liver), underscoring the role of epigenetic and regulatory mechanisms underlying cardio‐metabolic traits. However, within this abstract no direct mention or functional characterization of the lncRNA HS1BP3-IT1 is provided.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Thus, while the study exemplifies how regulatory elements can influence metabolic traits, no functional insights into HS1BP3-IT1 are described. As a result, its role within the regulatory landscape affecting adiposity and glycemic traits remains to be elucidated based on the evidence provided in this abstract.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hagit Hochner, Catherine Allard, Einat Granot-Hershkovitz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Parent-of-Origin Effects of the APOB Gene on Adiposity in Young Adults."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1005573"}], "href": "https://doi.org/10.1371/journal.pgen.1005573"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26451733"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26451733"}]}]}]}