HSF4 Gene

Name	heat shock transcription factor 4
Description	Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nHSF4 is a pivotal transcription factor in the eye that governs lens development and differentiation, with mutations in its coding regions causing both congenital and age‐related cataracts. Multiple family‐based and experimental studies have shown that diverse mutations—including missense, nonsense, and frameshift alterations—in HSF4’s DNA‐binding or functional domains impair its ability to regulate essential target genes. In doing so, HSF4 normally activates the transcription of lens structural proteins (such as crystallins and beaded filament proteins) and factors required for fiber cell maturation and nuclear degradation (for example, DLAD), thereby ensuring proper lens proteostasis. Disruption of these processes leads to abnormal lens cell proliferation, defective fiber cell denucleation, and subsequent lens opacities."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAt the molecular level, HSF4 functions as a transcriptional regulator by binding to heat shock elements (HSEs) in the promoters of its target genes, thereby modulating stress responses, DNA repair, and cell cycle regulation in lens epithelial cells. HSF4 not only stimulates the expression of key anti‐oxidant and DNA repair mediators such as HMOX‑1 and Rad51 but also orchestrates the balance between cell proliferation and differentiation by engaging signaling pathways that involve p53 and its downstream effector p21. Its activity is further modulated by co‐regulatory proteins (for instance, by recruiting chromatin remodelers like Brg1 and interacting with factors such as BCAS2) and by phosphorylation events mediated by MAP kinase p38, which together ensure precise temporal control of gene transcription during the cell cycle."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond the ocular lens, emerging evidence highlights roles for HSF4 in non‐ocular tissues where it influences cellular stress responses and oncogenic processes. In cancer cells, for example, HSF4 – together with related family members – contributes to the maintenance of a repressed state of hypoxia‐inducible factor 1α (HIF‑1α) transcription, thereby modulating VEGF production and angiogenesis. Increased HSF4 expression has been correlated with advanced tumor stage and poorer clinical outcomes in colorectal cancer, and recent studies have begun to uncover regulatory mechanisms affecting HSF4 activity such as miRNA binding within its coding region. These findings suggest that HSF4’s regulatory functions may extend to broader roles in tumor biology and stress adaptation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "19", "end_ref": "22"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lei Bu, Yiping Jin, Yuefeng Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutant DNA-binding domain of HSF4 is associated with autosomal dominant lamellar and Marner cataract."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng921"}], "href": "https://doi.org/10.1038/ng921"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12089525"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12089525"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Nizar Smaoui, Omar Beltaief, Sonia BenHamed, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A homozygous splice mutation in the HSF4 gene is associated with an autosomal recessive congenital cataract."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Invest Ophthalmol Vis Sci (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1167/iovs.03-1370"}], "href": "https://doi.org/10.1167/iovs.03-1370"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15277496"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15277496"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "T Somasundaram, Suraj P Bhat "}, {"type": "b", "children": [{"type": "t", "text": "Developmentally dictated expression of heat shock factors: exclusive expression of HSF4 in the postnatal lens and its specific interaction with alphaB-crystallin heat shock promoter."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M405813200"}], "href": "https://doi.org/10.1074/jbc.M405813200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15308659"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15308659"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Tim Forshew, Colin A Johnson, Shagufta Khaliq, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Locus heterogeneity in autosomal recessive congenital cataracts: linkage to 9q and germline HSF4 mutations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Genet (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00439-005-1309-9"}], "href": "https://doi.org/10.1007/s00439-005-1309-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15959809"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15959809"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Tie Ke, Qing K Wang, Binchu Ji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel HSF4 mutation causes congenital total white cataract in a Chinese family."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Ophthalmol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajo.2006.03.056"}], "href": "https://doi.org/10.1016/j.ajo.2006.03.056"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16876512"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16876512"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yuefeng Shi, Xiaohe Shi, Yiping Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutation screening of HSF4 in 150 age-related cataract patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Vis (2008)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18941546"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18941546"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Naheed Sajjad, Ingrid Goebel, Naseebullah Kakar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel HSF4 gene mutation (p.R405X) causing autosomal recessive congenital cataracts in a large consanguineous family from Pakistan."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Med Genet (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2350-9-99"}], "href": "https://doi.org/10.1186/1471-2350-9-99"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19014451"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19014451"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yasuaki Enoki, Yuka Mukoda, Chie Furutani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DNA-binding and transcriptional activities of human HSF4 containing mutations that associate with congenital and age-related cataracts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbadis.2010.06.001"}], "href": "https://doi.org/10.1016/j.bbadis.2010.06.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20670914"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20670914"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Xiukun Cui, Lei Wang, Jing Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HSF4 regulates DLAD expression and promotes lens de-nucleation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbadis.2013.03.007"}], "href": "https://doi.org/10.1016/j.bbadis.2013.03.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23507146"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23507146"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Meng Gao, Yuwen Huang, Ling Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HSF4 regulates lens fiber cell differentiation by activating p53 and its downstream regulators."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cddis.2017.478"}], "href": "https://doi.org/10.1038/cddis.2017.478"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28981088"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28981088"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "V Berry, N Pontikos, A Moore, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel missense mutation in HSF4 causes autosomal-dominant congenital lamellar cataract in a British family."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eye (Lond) (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/eye.2017.268"}], "href": "https://doi.org/10.1038/eye.2017.268"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29243736"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29243736"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Naxin Tu, Yanzhong Hu, Nahid F Mivechi "}, {"type": "b", "children": [{"type": "t", "text": "Heat shock transcription factor (Hsf)-4b recruits Brg1 during the G1 phase of the cell cycle and regulates the expression of heat shock proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.20865"}], "href": "https://doi.org/10.1002/jcb.20865"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16552721"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16552721"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Zheng-yi Ma, Jun Zhang, Xue-li Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Construction of eukaryotic plasmid expression Hsf4b and phosphorylation of Hsf4b by MAP kinase P38]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi (2010)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20564821"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20564821"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Xiukun Cui, Jing Zhang, Rong Du, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HSF4 is involved in DNA damage repair through regulation of Rad51."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbadis.2012.05.005"}], "href": "https://doi.org/10.1016/j.bbadis.2012.05.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22587838"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22587838"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Jin Jiang, Jing Zhou, Yong Yao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Copy number variations of DNA repair genes and the age-related cataract: Jiangsu Eye Study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Invest Ophthalmol Vis Sci (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1167/iovs.12-10948"}], "href": "https://doi.org/10.1167/iovs.12-10948"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23329665"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23329665"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Mi Huang, Duanzhuo Li, Yuwen Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HSF4 promotes G1/S arrest in human lens epithelial cells by stabilizing p53."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamcr.2015.04.018"}], "href": "https://doi.org/10.1016/j.bbamcr.2015.04.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25940838"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25940838"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Shengjie Liao, Rong Du, Lei Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BCAS2 interacts with HSF4 and negatively regulates its protein stability via ubiquitination."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biochem Cell Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biocel.2015.08.016"}], "href": "https://doi.org/10.1016/j.biocel.2015.08.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26319152"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26319152"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Xiaoyu Zhang, Rui Wei, Yizhuo Sun, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Cadherin 22 participates in the self-renewal of mouse female germ line stem cells via interaction with JAK2 and β-catenin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Life Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00018-017-2689-4"}], "href": "https://doi.org/10.1007/s00018-017-2689-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29063123"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29063123"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Vanita Berry, Alex Ionides, Nikolas Pontikos, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Variants in PAX6, PITX3 and HSF4 causing autosomal dominant congenital cataracts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eye (Lond) (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41433-021-01711-x"}], "href": "https://doi.org/10.1038/s41433-021-01711-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34345029"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34345029"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Jinghua Liu, Kelin Yue, Junya Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-330-5p Suppress Cell Growth and Invasion via Disrupting HSF4-mediated MACC1/STAT3 Pathway in Colorectal Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Biosci (Landmark Ed) (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.31083/j.fbl2902053"}], "href": "https://doi.org/10.31083/j.fbl2902053"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38420805"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38420805"}]}]}]}
Synonyms	CTM, CTRCT5
Proteins	HSF4_HUMAN
NCBI Gene ID	3299
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

HSF4 has 4,959 functional associations with biological entities spanning 8 categories (molecular profile, organism, disease, phenotype or trait, chemical, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 110 datasets.

Click the + buttons to view associations for HSF4 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

HSF4 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of HSF4 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of HSF4 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of HSF4 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of HSF4 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of HSF4 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of HSF4 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of HSF4 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of HSF4 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of HSF4 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of HSF4 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with HSF4 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of HSF4 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of HSF4 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of HSF4 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with HSF4 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of HSF4 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing HSF4 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing HSF4 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing HSF4 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with HSF4 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with HSF4 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of HSF4 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with HSF4 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with HSF4 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with HSF4 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by HSF4 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving HSF4 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving HSF4 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with HSF4 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with HSF4 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with HSF4 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with HSF4 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at HSF4 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of HSF4 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of HSF4 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing HSF4 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD High Level Gene-Disease Associations	diseases associated with HSF4 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of HSF4 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with HSF4 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing HSF4 from the GeneSigDB Published Gene Signatures dataset.