| Name | heat shock transcription factor family, X-linked member 4 |
| Description | Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Mar 2025] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe provided abstract"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "does not contain any information on HSFX4. Instead, it focuses on Nek3, a member of the NIMA‐related kinases, and its role in neuronal morphogenesis. According to the study, Nek3 influences neuronal polarity and morphology by modulating microtubule dynamics. In particular, the phosphorylation of Nek3 at Thr475 within its C-terminal PEST domain regulates its catalytic activity. When unphosphorylated, Nek3 triggers deacetylation of microtubules via HDAC6, leading to altered neuronal structure and polarity, which may contribute to pathological conditions involving axonal degeneration. Since no details about HSFX4 are provided in this abstract, its function remains unaddressed in this context.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jufang Chang, Robert H Baloh, Jeffrey Milbrandt "}, {"type": "b", "children": [{"type": "t", "text": "The NIMA-family kinase Nek3 regulates microtubule acetylation in neurons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.048975"}], "href": "https://doi.org/10.1242/jcs.048975"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19509051"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19509051"}]}]}]}
|
| NCBI Gene ID | 101927685 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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HSFX4 has 168 functional associations with biological entities spanning 5 categories (functional term, phrase or reference, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 8 datasets.
Click the + buttons to view associations for HSFX4 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of HSFX4 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with HSFX4 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with HSFX4 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of HSFX4 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of HSFX4 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of HSFX4 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of HSFX4 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with HSFX4 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |