HSPB6 Gene

HGNC Family	Protein phosphatase 1 regulatory subunits (PPP1R), Heat shock proteins
Name	heat shock protein, alpha-crystallin-related, B6
Description	This locus encodes a heat shock protein. The encoded protein likely plays a role in smooth muscle relaxation. [provided by RefSeq, Jan 2012]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n HSPB6 (also known as Hsp20) is a multifunctional small heat‐shock protein that plays key roles in promoting cellular protection, regulating contractile function, and maintaining protein homeostasis in diverse tissues. In the heart, HSPB6 exerts potent cardioprotective effects against ischemia/reperfusion injury, sustained β‐adrenergic stimulation, and even septic insults by modulating critical signal transduction pathways – for example, by inhibiting stress kinase cascades and orchestrating sarcoplasmic reticulum Ca²⁺ cycling through effects on phospholamban phosphorylation and PP1 activity (see."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": " These protective effects are highly dependent on post‐translational modifications. In particular, phosphorylation of HSPB6 at Ser16 is required for its antiapoptotic and cytoprotective actions, as it enables binding to regulatory proteins such as 14–3–3; this interaction not only promotes structural remodeling of HSPB6 into an active conformation but also augments its chaperone activity (see."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "9"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its direct cardioprotective roles, HSPB6 functions as an important chaperone that interacts with co‐chaperones including BAG3. Through such interactions—where BAG3 binds HSPB6 via conserved IPV motifs—HSPB6 participates in the clearance of misfolded and aggregation‐prone proteins, thereby contributing to proteostasis in muscle and neuronal cells."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "12"}]}, {"type": "t", "text": " Moreover, in cardiac tissue HSPB6 is secreted via exosomes to function as a cardiokine; secreted HSPB6 can promote angiogenesis through its engagement with VEGF receptor signaling"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": ", and in smooth muscle such as the myometrium, acetylation of HSPB6 has been linked to the regulation of contractile activity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Outside the cardiovascular system, alterations in HSPB6 expression—such as promoter hypermethylation observed in melanoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "and its upregulation in non‐tumor liver tissues"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": "—suggest a potential role in modulating cellular growth and differentiation, implicating HSPB6 as a candidate tumor suppressor. Collectively, the structural dynamics, post‐translational modifications, and protein–protein interactions of HSPB6 underscore its central role in integrating stress signaling, chaperone-mediated protein quality control, and contractile regulation, making it an attractive therapeutic target in cardiovascular, fibrotic, and neoplastic diseases."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiao-Ping Ren, Jinghai Wu, Xiaohong Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-320 is involved in the regulation of cardiac ischemia/reperfusion injury by targeting heat-shock protein 20."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circulation (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCULATIONAHA.108.814145"}], "href": "https://doi.org/10.1161/CIRCULATIONAHA.108.814145"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19380620"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19380620"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Evangelia G Kranias, Roger J Hajjar "}, {"type": "b", "children": [{"type": "t", "text": "Modulation of cardiac contractility by the phospholamban/SERCA2a regulatome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.111.259754"}], "href": "https://doi.org/10.1161/CIRCRESAHA.111.259754"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22679139"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22679139"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jiang Qian, Xiaoping Ren, Xiaohong Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Blockade of Hsp20 phosphorylation exacerbates cardiac ischemia/reperfusion injury by suppressed autophagy and increased cell death."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.109.200378"}], "href": "https://doi.org/10.1161/CIRCRESAHA.109.200378"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19850943"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19850943"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Guo-Chang Fan, Qunying Yuan, Guojie Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Small heat-shock protein Hsp20 attenuates beta-agonist-mediated cardiac remodeling through apoptosis signal-regulating kinase 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/01.RES.0000251074.19348.af"}], "href": "https://doi.org/10.1161/01.RES.0000251074.19348.af"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17068291"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17068291"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jiang Qian, Elizabeth Vafiadaki, Stela M Florea, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Small heat shock protein 20 interacts with protein phosphatase-1 and enhances sarcoplasmic reticulum calcium cycling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.110.237644"}], "href": "https://doi.org/10.1161/CIRCRESAHA.110.237644"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21493896"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21493896"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xiaohong Wang, Basilia Zingarelli, Michael O'Connor, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of Hsp20 prevents endotoxin-induced myocardial dysfunction and apoptosis via inhibition of NF-kappaB activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Cell Cardiol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yjmcc.2009.05.016"}], "href": "https://doi.org/10.1016/j.yjmcc.2009.05.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19501592"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19501592"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Nikolai N Sluchanko, Steven Beelen, Alexandra A Kulikova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural Basis for the Interaction of a Human Small Heat Shock Protein with the 14-3-3 Universal Signaling Regulator."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Structure (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.str.2016.12.005"}], "href": "https://doi.org/10.1016/j.str.2016.12.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28089448"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28089448"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Ivan S Chernik, Alim S Seit-Nebi, Steven B Marston, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Small heat shock protein Hsp20 (HspB6) as a partner of 14-3-3gamma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-006-9266-8"}], "href": "https://doi.org/10.1007/s11010-006-9266-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17109079"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17109079"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Persoulla Nicolaou, Ralph Knöll, Kobra Haghighi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human mutation in the anti-apoptotic heat shock protein 20 abrogates its cardioprotective effects."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M802307200"}], "href": "https://doi.org/10.1074/jbc.M802307200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18790732"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18790732"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Margit Fuchs, Dominic J Poirier, Samuel J Seguin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of the key structural motifs involved in HspB8/HspB6-Bag3 interaction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20090907"}], "href": "https://doi.org/10.1042/BJ20090907"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19845507"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19845507"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Jennifer N Rauch, Eric Tse, Rebecca Freilich, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BAG3 Is a Modular, Scaffolding Protein that physically Links Heat Shock Protein 70 (Hsp70) to the Small Heat Shock Proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2016.11.013"}], "href": "https://doi.org/10.1016/j.jmb.2016.11.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27884606"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27884606"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Anton A Shemetov, Nikolai B Gusev "}, {"type": "b", "children": [{"type": "t", "text": "Biochemical characterization of small heat shock protein HspB8 (Hsp22)-Bag3 interaction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Biochem Biophys (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.abb.2011.06.014"}], "href": "https://doi.org/10.1016/j.abb.2011.06.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21767525"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21767525"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Xiaowei Zhang, Xiaohong Wang, Hongyan Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hsp20 functions as a novel cardiokine in promoting angiogenesis via activation of VEGFR2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0032765"}], "href": "https://doi.org/10.1371/journal.pone.0032765"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22427880"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22427880"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Magdalena Karolczak-Bayatti, Michèle Sweeney, Joanna Cheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Acetylation of heat shock protein 20 (Hsp20) regulates human myometrial activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.278549"}], "href": "https://doi.org/10.1074/jbc.M111.278549"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21803775"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21803775"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Luciana B Lopes, Elizabeth J Furnish, Padmini Komalavilas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cell permeant peptide analogues of the small heat shock protein, HSP20, reduce TGF-beta1-induced CTGF expression in keloid fibroblasts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Invest Dermatol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/jid.2008.264"}], "href": "https://doi.org/10.1038/jid.2008.264"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18787533"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18787533"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Yasuo Koga, Mattia Pelizzola, Elaine Cheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide screen of promoter methylation identifies novel markers in melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genome Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gr.091447.109"}], "href": "https://doi.org/10.1101/gr.091447.109"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19491193"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19491193"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Zongguo Yang, Liping Zhuang, Peter Szatmary, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of heat shock proteins (HSPA12A, HSP90B1, HSPA4, HSPA5 and HSPA6) in tumour tissues is associated with poor outcomes from HBV-related early-stage hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Med Sci (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/ijms.10735"}], "href": "https://doi.org/10.7150/ijms.10735"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25798051"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25798051"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "C Bagnéris, O A Bateman, C E Naylor, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Crystal structures of alpha-crystallin domain dimers of alphaB-crystallin and Hsp20."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2009.07.069"}], "href": "https://doi.org/10.1016/j.jmb.2009.07.069"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19646995"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19646995"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Jorunn Stamnaes, Burkhard Fleckenstein, Ludvig M Sollid "}, {"type": "b", "children": [{"type": "t", "text": "The propensity for deamidation and transamidation of peptides by transglutaminase 2 is dependent on substrate affinity and reaction conditions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbapap.2008.08.011"}], "href": "https://doi.org/10.1016/j.bbapap.2008.08.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18793760"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18793760"}]}]}]}
Synonyms	HEL55, PPP1R91, HSP20
Proteins	HSPB6_HUMAN
NCBI Gene ID	126393
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

HSPB6 has 5,939 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 114 datasets.

Click the + buttons to view associations for HSPB6 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

HSPB6 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of HSPB6 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of HSPB6 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of HSPB6 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of HSPB6 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of HSPB6 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of HSPB6 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of HSPB6 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of HSPB6 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of HSPB6 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of HSPB6 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of HSPB6 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of HSPB6 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with HSPB6 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of HSPB6 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of HSPB6 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of HSPB6 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of HSPB6 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing HSPB6 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing HSPB6 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with HSPB6 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with HSPB6 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of HSPB6 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with HSPB6 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with HSPB6 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with HSPB6 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by HSPB6 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with HSPB6 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with HSPB6 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with HSPB6 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with HSPB6 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with HSPB6 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at HSPB6 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of HSPB6 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of HSPB6 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing HSPB6 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with HSPB6 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of HSPB6 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with HSPB6 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing HSPB6 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of HSPB6 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.