HGNC Family | G protein-coupled receptors, 5-hydroxytryptamine (serotonin) receptors (HTR) |
Name | 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled |
Description | The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member of 5-hydroxytryptamine (serotonin) receptor family and encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples to G-proteins. This protein has been shown to function in part through the regulation of intracellular Ca2+ mobilization. [provided by RefSeq, Jul 2008] |
Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n The serotonin 5A receptor (HTR5A) has emerged as a versatile modulator in both central and peripheral systems. Cloned as a 357–amino acid protein that is predominantly expressed in the brain, HTR5A shows a pharmacological profile similar to its rodent homologs, with high‐affinity binding to ergot alkaloids, underscoring its potential role in neurotransmission."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In neurodevelopment and behavior, genetic variations and differential expression of HTR5A have been implicated in autism spectrum disorder and mood regulation, with certain polymorphisms and epigenetic modifications being associated with altered risk for autism and mood disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, investigations in schizophrenia have identified specific single nucleotide polymorphisms in HTR5A that correlate with the disease and with measures of executive function"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", while studies in personality research suggest that HTR5A expression levels may be linked to traits such as openness and, by extension, to broader neurobehavioral phenotypes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its established roles in brain function, HTR5A is increasingly recognized for its involvement in peripheral physiology. Genetic studies have associated sequence variants in HTR5A with elevated plasma triglyceride levels, suggesting an as-yet–unappreciated interface between central serotonergic signaling and metabolic regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In line with this, cortisol has been shown to up-regulate the expression of HTR5A in adipocyte and macrophage cultures, contributing to enhanced adipogenesis under stress conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the realm of oncology, HTR5A has garnered attention as a promising therapeutic target. In prostate cancer, antagonists of the 5-HT5A receptor were found to suppress androgen receptor activity via protein kinase A signaling, while differential HTR5A expression has been reported in SPOP-mutant prostate tumors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Similarly, in breast cancer models, selective antagonism of HTR5A reduced the frequency of tumor-initiating cells and enhanced the efficacy of chemotherapy, highlighting its potential role in targeting cancer stem-like cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Additional studies indicate that HTR5A is also engaged in the modulation of stress and fear responses. Differential methylation of the HTR5A gene has been observed in animal models exposed to prenatal or acute stress, and its altered expression has been linked to variations in fear memory and behavioral reactivity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " Notably, decreased HTR5A expression in certain avian models correlates with heightened neophobic behavior, suggesting that HTR5A may contribute to the regulation of risk-taking and exploratory traits."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Finally, emerging data in developmental neuroscience show that HTR5A is expressed in glial populations within human cortical spheroids and avian raphe nuclei, implicating the receptor in the shaping of neural circuits during early brain development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": " There is also preliminary evidence hinting at a role for HTR5A in modulating cardiac sympathetic neurotransmission."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these findings portray HTR5A as a multifunctional serotonin receptor with diverse roles ranging from the fine-tuning of neuronal signaling and behavior to the regulation of metabolic pathways and tumor biology.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "S Rees, I den Daas, S Foord, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cloning and characterisation of the human 5-HT5A serotonin receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (1994)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/0014-5793(94)01209-1"}], "href": "https://doi.org/10.1016/0014-5793(94"}, {"type": "t", "text": "01209-1) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "7988681"}], "href": "https://pubmed.ncbi.nlm.nih.gov/7988681"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ana M Coutinho, Inês Sousa, Madalena Martins, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Evidence for epistasis between SLC6A4 and ITGB3 in autism etiology and in the determination of platelet serotonin levels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Genet (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00439-006-0301-3"}], "href": "https://doi.org/10.1007/s00439-006-0301-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17203304"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17203304"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "J Brezo, A Bureau, C Mérette, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differences and similarities in the serotonergic diathesis for suicide attempts and mood disorders: a 22-year longitudinal gene-environment study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Psychiatry (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/mp.2009.19"}], "href": "https://doi.org/10.1038/mp.2009.19"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19381154"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19381154"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Fanglin Guan, Huali Lin, Gang Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Evaluation of association of common variants in HTR1A and HTR5A with schizophrenia and executive function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep38048"}], "href": "https://doi.org/10.1038/srep38048"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27897266"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27897266"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Han-Na Kim, Seung-Ju Roh, Yeon Ah Sung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study of the five-factor model of personality in young Korean women."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hum Genet (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/jhg.2013.75"}], "href": "https://doi.org/10.1038/jhg.2013.75"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23903073"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23903073"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Y Zhang, E M Smith, T M Baye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Serotonin (5-HT) receptor 5A sequence variants affect human plasma triglyceride levels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Physiol Genomics (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/physiolgenomics.00038.2010"}], "href": "https://doi.org/10.1152/physiolgenomics.00038.2010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20388841"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20388841"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Sushri Priyadarshini, Biswaranjan Pradhan, Philip Griebel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cortisol regulates immune and metabolic processes in murine adipocytes and macrophages through HTR2c and HTR5a serotonin receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Cell Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejcb.2018.07.004"}], "href": "https://doi.org/10.1016/j.ejcb.2018.07.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30097291"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30097291"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Momoe Itsumi, Masaki Shiota, Yohei Sekino, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High-throughput screen identifies 5-HT receptor as a modulator of AR and a therapeutic target for prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Prostate (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/pros.24022"}], "href": "https://doi.org/10.1002/pros.24022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32483877"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32483877"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Guanxiong Ding, Jianliang Sun, Lianhua Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Key pathways in prostate cancer with SPOP mutation identified by bioinformatic analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Open Med (Wars) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1515/med-2020-0237"}], "href": "https://doi.org/10.1515/med-2020-0237"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33336059"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33336059"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "William D Gwynne, Mirza S Shakeel, Adele Girgis-Gabardo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Antagonists of the serotonin receptor 5A target human breast tumor initiating cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-020-07193-6"}], "href": "https://doi.org/10.1186/s12885-020-07193-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32758183"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32758183"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Brittni P Littlejohn, Deborah M Price, Don A Neuendorff, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Influence of prenatal transportation stress-induced differential DNA methylation on the physiological control of behavior and stress response in suckling Brahman bull calves."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Anim Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jas/skz368"}], "href": "https://doi.org/10.1093/jas/skz368"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31807776"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31807776"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Yan Sun, Wei Lu, Kaixin Du, et al. "}, {"type": "b", "children": [{"type": "t", "text": "microRNA and mRNA profiles in the amygdala are relevant to fear memory induced by physical or psychological stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurophysiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/jn.00215.2019"}], "href": "https://doi.org/10.1152/jn.00215.2019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31268807"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31268807"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Christine R Lattin, Tosha R Kelly, Morgan W Kelly, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Constitutive gene expression differs in three brain regions important for cognition in neophobic and non-neophobic house sparrows (Passer domesticus)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0267180"}], "href": "https://doi.org/10.1371/journal.pone.0267180"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35536842"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35536842"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Kinsley Tate, Brenna Kirk, Alisia Tseng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effects of the Selective Serotonin Reuptake Inhibitor Fluoxetine on Developing Neural Circuits in a Model of the Human Fetal Cortex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms221910457"}], "href": "https://doi.org/10.3390/ijms221910457"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34638815"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34638815"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Toshiyuki Fujita, Naoya Aoki, Chihiro Mori, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Serotonergic Neurons in the Chick Brainstem Express Various Serotonin Receptor Subfamily Genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Physiol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fphys.2021.815997"}], "href": "https://doi.org/10.3389/fphys.2021.815997"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35111079"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35111079"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "José Ángel García-Pedraza, Oswaldo Hernández-Abreu, Asunción Morán, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of peripheral 5-HT"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "5A"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": " receptors in 5-HT-induced cardiac sympatho-inhibition in type 1 diabetic rats."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-020-76298-6"}], "href": "https://doi.org/10.1038/s41598-020-76298-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33168874"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33168874"}]}]}]}
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Synonyms | 5-HT5A |
Proteins | 5HT5A_HUMAN |
NCBI Gene ID | 3361 |
API | |
Download Associations | |
Predicted Functions |
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Co-expressed Genes |
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Expression in Tissues and Cell Lines |
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HTR5A has 3,311 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 94 datasets.
Click the + buttons to view associations for HTR5A from the datasets below.
If available, associations are ranked by standardized value
Dataset | Summary | |
---|---|---|
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of HTR5A gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of HTR5A gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of HTR5A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of HTR5A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of HTR5A gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of HTR5A gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of HTR5A gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of HTR5A gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of HTR5A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of HTR5A gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of HTR5A gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
ChEA Transcription Factor Targets | transcription factors binding the promoter of HTR5A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of HTR5A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of HTR5A gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing HTR5A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing HTR5A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with HTR5A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with HTR5A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of HTR5A gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
COSMIC Cell Line Gene Mutation Profiles | cell lines with HTR5A gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
CTD Gene-Disease Associations | diseases associated with HTR5A gene/protein from the curated CTD Gene-Disease Associations dataset. | |
DepMap CRISPR Gene Dependency | cell lines with fitness changed by HTR5A gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with HTR5A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with HTR5A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DisGeNET Gene-Disease Associations | diseases associated with HTR5A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
DisGeNET Gene-Phenotype Associations | phenotypes associated with HTR5A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
DrugBank Drug Targets | interacting drugs for HTR5A protein from the curated DrugBank Drug Targets dataset. | |
ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at HTR5A gene from the ENCODE Histone Modification Site Profiles dataset. | |
ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of HTR5A gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
ENCODE Transcription Factor Targets | transcription factors binding the promoter of HTR5A gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing HTR5A from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
GAD Gene-Disease Associations | diseases associated with HTR5A gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
GAD High Level Gene-Disease Associations | diseases associated with HTR5A gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of HTR5A gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
GeneRIF Biological Term Annotations | biological terms co-occuring with HTR5A gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing HTR5A from the GeneSigDB Published Gene Signatures dataset. | |
GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of HTR5A gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of HTR5A gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of HTR5A gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of HTR5A gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of HTR5A gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of HTR5A gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
GO Biological Process Annotations 2015 | biological processes involving HTR5A gene from the curated GO Biological Process Annotations 2015 dataset. | |
GO Biological Process Annotations 2023 | biological processes involving HTR5A gene from the curated GO Biological Process Annotations 2023 dataset. | |
GO Biological Process Annotations 2025 | biological processes involving HTR5A gene from the curated GO Biological Process Annotations2025 dataset. | |
GO Cellular Component Annotations 2015 | cellular components containing HTR5A protein from the curated GO Cellular Component Annotations 2015 dataset. | |
GO Cellular Component Annotations 2023 | cellular components containing HTR5A protein from the curated GO Cellular Component Annotations 2023 dataset. | |
GO Cellular Component Annotations 2025 | cellular components containing HTR5A protein from the curated GO Cellular Component Annotations 2025 dataset. | |
GO Molecular Function Annotations 2015 | molecular functions performed by HTR5A gene from the curated GO Molecular Function Annotations 2015 dataset. | |
GO Molecular Function Annotations 2023 | molecular functions performed by HTR5A gene from the curated GO Molecular Function Annotations 2023 dataset. | |
GO Molecular Function Annotations 2025 | molecular functions performed by HTR5A gene from the curated GO Molecular Function Annotations 2025 dataset. | |
GTEx eQTL 2025 | SNPs regulating expression of HTR5A gene from the GTEx eQTL 2025 dataset. | |
GTEx Tissue Gene Expression Profiles | tissues with high or low expression of HTR5A gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of HTR5A gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
Guide to Pharmacology Chemical Ligands of Receptors | ligands (chemical) binding HTR5A receptor from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset. | |
GWASdb SNP-Disease Associations | diseases associated with HTR5A gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
GWASdb SNP-Phenotype Associations | phenotypes associated with HTR5A gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of HTR5A gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
HMDB Metabolites of Enzymes | interacting metabolites for HTR5A protein from the curated HMDB Metabolites of Enzymes dataset. | |
HPA Tissue Protein Expression Profiles | tissues with high or low expression of HTR5A protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
HuGE Navigator Gene-Phenotype Associations | phenotypes associated with HTR5A gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
InterPro Predicted Protein Domain Annotations | protein domains predicted for HTR5A protein from the InterPro Predicted Protein Domain Annotations dataset. | |
JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of HTR5A gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
KEGG Pathways | pathways involving HTR5A protein from the KEGG Pathways dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of HTR5A gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of HTR5A gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of HTR5A gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
LOCATE Curated Protein Localization Annotations | cellular components containing HTR5A protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by HTR5A gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of HTR5A gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
MPO Gene-Phenotype Associations | phenotypes of transgenic mice caused by HTR5A gene mutations from the MPO Gene-Phenotype Associations dataset. | |
PANTHER Pathways | pathways involving HTR5A protein from the PANTHER Pathways dataset. | |
Pathway Commons Protein-Protein Interactions | interacting proteins for HTR5A from the Pathway Commons Protein-Protein Interactions dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of HTR5A gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of HTR5A gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PFOCR Pathway Figure Associations 2023 | pathways involving HTR5A protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
PFOCR Pathway Figure Associations 2024 | pathways involving HTR5A protein from the Wikipathways PFOCR 2024 dataset. | |
Reactome Pathways 2014 | pathways involving HTR5A protein from the Reactome Pathways dataset. | |
Reactome Pathways 2024 | pathways involving HTR5A protein from the Reactome Pathways 2024 dataset. | |
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of HTR5A gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at HTR5A gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of HTR5A gene from the RummaGEO Drug Perturbation Signatures dataset. | |
RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of HTR5A gene from the RummaGEO Gene Perturbation Signatures dataset. | |
SynGO Synaptic Gene Annotations | synaptic terms associated with HTR5A gene from the SynGO Synaptic Gene Annotations dataset. | |
TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of HTR5A gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of HTR5A gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of HTR5A gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of HTR5A protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of HTR5A protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of HTR5A protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with HTR5A protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with HTR5A protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
WikiPathways Pathways 2014 | pathways involving HTR5A protein from the Wikipathways Pathways 2014 dataset. | |
WikiPathways Pathways 2024 | pathways involving HTR5A protein from the WikiPathways Pathways 2024 dataset. | |