HULC Gene

HGNC Family Non-coding RNAs
Name hepatocellular carcinoma up-regulated long non-coding RNA
Description This gene produces a long RNA that was discovered as upregulated in hepatocellular carcinoma and is associated with cancer progression. Expression of this transcript is regulated by microRNAs and at the transcriptional level by Sp1 family factors. The transcript may regulate gene expression by functioning as a competing RNA for microRNAs. [provided by RefSeq, Dec 2017]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n A recent meta‐analysis of 9 studies comprising 966 cancer patients demonstrated that high expression of the long non-coding RNA HULC is significantly associated with increased metastasis and poorer prognosis in various cancers. Elevated HULC levels were linked to a higher risk of both lymph node metastasis (pooled odds ratio = 4.83) and distant metastasis (pooled odds ratio = 5.44), as well as markedly reduced overall survival (pooled hazard ratio = 1.48), with even stronger associations observed in Chinese patients (pooled hazard ratio = 2.04). Moreover, high HULC expression correlated with an increased risk of recurrence, supporting its potential utility as a biomarker for therapeutic guidance and prognostic surveillance in cancer management."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiaoliang Chen, Jinbo Lin, Yi Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AlncRNA HULC as an effective biomarker for surveillance of the outcome of cancer: A meta-analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0171210"}], "href": "https://doi.org/10.1371/journal.pone.0171210"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28146578"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28146578"}]}]}]}
Synonyms LINC00078, HCCAT1, NCRNA00078
NCBI Gene ID 728655
API
Download Associations
Predicted Functions View HULC's ARCHS4 Predicted Functions.
Co-expressed Genes View HULC's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View HULC's ARCHS4 Predicted Functions.

Functional Associations

HULC has 648 functional associations with biological entities spanning 5 categories (molecular profile, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 18 datasets.

Click the + buttons to view associations for HULC from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of HULC gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of HULC gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of HULC gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of HULC gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at HULC gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of HULC gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of HULC gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with HULC gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of HULC gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of HULC gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
GWASdb SNP-Disease Associations diseases associated with HULC gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.
GWASdb SNP-Phenotype Associations phenotypes associated with HULC gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.
HuGE Navigator Gene-Phenotype Associations phenotypes associated with HULC gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of HULC gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of HULC gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of HULC gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of HULC gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
TCGA Signatures of Differentially Expressed Genes for Tumors tissue samples with high or low expression of HULC gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.