HYCC2 Gene

Name hyccin PI4KA lipid kinase complex subunit 2
Description Predicted to be involved in phosphatidylinositol phosphate biosynthetic process and protein localization to plasma membrane. Predicted to be located in cytosol and membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nHYCC2 is a testis‐enriched gene that has been flagged as a potential regulator in spermatogenesis, a process whereby developing sperm cells mature in the testes. Although its expression pattern suggests a role in the complex orchestration of germ cell development, the precise molecular functions and pathways mediated by HYCC2 remain unclear. The available evidence underscores that, like several other testis‐specific genes, HYCC2 may contribute to key signaling cascades or structural modifications critical for normal spermatogenic progression, yet its definitive mechanism of action awaits further elucidation (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nEmerging studies imply that HYCC2 might be part of a broader regulatory network that controls the proliferation and differentiation of germ cells. This potential involvement positions HYCC2 as an intriguing candidate for future research aimed at dissecting the molecular underpinnings of male fertility. Comprehensive functional analyses are needed to clarify the exact role of HYCC2 among the many testis‐enriched factors whose contributions to spermatogenesis have not been fully characterized (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hongge Xu, Hongyan Ding, Haoyu Zheng "}, {"type": "b", "children": [{"type": "t", "text": "Murine fertility and spermatogenesis are independent of the testis-specific Spdye4a gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gen Comp Endocrinol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ygcen.2022.114148"}], "href": "https://doi.org/10.1016/j.ygcen.2022.114148"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36272447"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36272447"}]}]}]}
NCBI Gene ID 285172
API
Download Associations
Predicted Functions View HYCC2's ARCHS4 Predicted Functions.
Co-expressed Genes View HYCC2's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View HYCC2's ARCHS4 Predicted Functions.

Functional Associations

HYCC2 has 1,277 functional associations with biological entities spanning 5 categories (functional term, phrase or reference, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 22 datasets.

Click the + buttons to view associations for HYCC2 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles tissue samples with high or low expression of HYCC2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
CellMarker Gene-Cell Type Associations cell types associated with HYCC2 gene from the CellMarker Gene-Cell Type Associations dataset.
CM4AI KOLF21J CRISPRi Gene Perturbation Atlas gene perturbations changing expression of HYCC2 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with HYCC2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
GO Biological Process Annotations 2025 biological processes involving HYCC2 gene from the curated GO Biological Process Annotations2025 dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of HYCC2 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
GWAS Catalog SNP-Phenotype Associations 2025 phenotypes associated with HYCC2 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.
JASPAR Predicted Human Transcription Factor Targets 2025 transcription factors regulating expression of HYCC2 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
JASPAR Predicted Mouse Transcription Factor Targets 2025 transcription factors regulating expression of HYCC2 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset.
Kinase Library Tyrosine Kinome Atlas kinases that phosphorylate HYCC2 protein from the Kinase Library Tyrosine Kinome Atlas dataset.
MoTrPAC Rat Endurance Exercise Training tissue samples with high or low expression of HYCC2 gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset.
Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of HYCC2 gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset.
Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of HYCC2 gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset.
Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of HYCC2 gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset.
Rummagene Transcription Factor Associations 2026 transcription factors regulating expression of HYCC2 gene from the Rummagene Transcription Factor Associations 2026 dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of HYCC2 gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of HYCC2 gene from the RummaGEO Gene Perturbation Signatures dataset.
Sci-Plex Drug Perturbation Signatures drug perturbations changing expression of HYCC2 gene from the Sci-Plex Drug Perturbation Signatures dataset.
Tahoe Therapeutics Tahoe 100M Perturbation Atlas drug perturbations changing expression of HYCC2 gene from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 tissues with high expression of HYCC2 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 tissues with high expression of HYCC2 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with HYCC2 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.