{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n IBA57‐AS1 is an antisense long noncoding RNA that is implicated in the regulation of gene expression through mechanisms that include epistatic interactions and isoform‐specific modulation. Although its precise biological role requires further elucidation, emerging analytical tools are beginning to shed light on its function within complex regulatory networks. A recently developed nonlinear functional regression model for epistasis analysis enables the integration of RNA‐seq data with whole genome sequencing to capture detailed position‐level read count patterns, splicing variability, and transcriptional initiation differences (1). This innovative framework not only overcomes traditional limitations in summarizing gene expression with a single number but also provides enhanced power to detect gene–gene interactions by simultaneously analyzing all single nucleotide polymorphism (SNP) pairs within two genomic regions. By offering a finer resolution of isoform and position‐dependent information, the approach presents a promising strategy to uncover the potential regulatory roles of noncoding RNAs such as IBA57‐AS1, which may contribute to the modulation of transcriptomic complexity and genetic architecture underlying gene expression."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kelin Xu, Li Jin, Momiao Xiong "}, {"type": "b", "children": [{"type": "t", "text": "Functional regression method for whole genome eQTL epistasis analysis with sequencing data."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Genomics (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12864-017-3777-4"}], "href": "https://doi.org/10.1186/s12864-017-3777-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28521784"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28521784"}]}]}]}