{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have demonstrated that the long intergenic non-coding RNA LINC00337 plays a critical oncogenic role in esophageal cancer. In one investigation, LINC00337 was shown to recruit the transcription factor E2F4, thereby promoting TPX2 expression which in turn elevates autophagy-related proteins (Beclin1 and LC3II/LC3I) to enhance cell viability and resistance to cisplatin treatment. In a parallel study, LINC00337 was revealed to bind miR-145, releasing the miR-145-mediated inhibition of FSCN1 and consequently fostering cell proliferation, migration, invasion, and tumor growth while suppressing apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond esophageal malignancies, LINC00337 has been evaluated in other tumor types. In colorectal cancer, its expression has been correlated with tumor progression, suggesting that it may serve as an important biomarker or therapeutic target. Similarly, emerging data in pancreatic ductal adenocarcinoma indicate that LINC00337 is implicated in tumor development, extending its oncogenic influence across multiple gastrointestinal malignancies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, in the context of breast cancer, LINC00337 appears to contribute to tumor progression by modulating the tumor microenvironment. Specifically, it has been associated with the regulation of M2 tumor-associated macrophages, a cell type known to affect both tumor growth and therapeutic resistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chengliang Yang, Sining Shen, Xiaoli Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA LINC00337 induces autophagy and chemoresistance to cisplatin in esophageal squamous cell carcinoma cells via upregulation of TPX2 by recruiting E2F4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.201900731RR"}], "href": "https://doi.org/10.1096/fj.201900731RR"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32239565"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32239565"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Lixia Shi, Qing Chen, Xiaofen Ge "}, {"type": "b", "children": [{"type": "t", "text": "Long intergenic non-coding RNA 00337 confers progression of esophageal cancer by mediating microrna-145-dependent fscn1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.202000470"}], "href": "https://doi.org/10.1096/fj.202000470"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32654289"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32654289"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Z-G Wang, Y-G Yang, G-S Fu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Silencing of linc00337 inhibits proliferation, cell cycle progression, migration, and invasion of colorectal cancer cells through the MEK/ERK pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202005_21318"}], "href": "https://doi.org/10.26355/eurrev_202005_21318"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32495869"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32495869"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Huakai Wang, Shiyong Yu, Huan Peng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA Linc00337 functions as an E2F1 co-activator and promotes cell proliferation in pancreatic ductal adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-020-01725-5"}], "href": "https://doi.org/10.1186/s13046-020-01725-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33054826"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33054826"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Zeyu Xing, Menglu Zhang, Jiaqi Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00337 induces tumor development and chemoresistance to paclitaxel of breast cancer by recruiting M2 tumor-associated macrophages."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Immunol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molimm.2021.07.009"}], "href": "https://doi.org/10.1016/j.molimm.2021.07.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34314939"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34314939"}]}]}]}