{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ID2‐AS1 is a long noncoding RNA that plays distinct roles in different disease contexts. In hepatocellular carcinoma (HCC), reduced expression of ID2‐AS1 is associated with enhanced migration, invasion, and metastasis of cancer cells, which correlates with poorer overall patient survival. Mechanistically, ID2‐AS1 suppresses HCC metastasis by regulating the transcription of its adjacent gene, ID2, through interfering with the binding of histone deacetylase 8 (HDAC8) on the ID2 enhancer. This regulation ultimately impedes Twist‐induced epithelial–mesenchymal transition, highlighting an important epigenetic mechanism in cancer metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In contrast, in a Parkinson’s disease model using MPP⁺‐treated SH‐SY5Y neuroblastoma cells, ID2‐AS1 is upregulated in a concentration‐ and time‐dependent manner. Here, ID2‐AS1 acts as a sponge for miR‐199a‐5p, thereby modulating the expression of interferon alpha and beta receptor subunit 1 (IFNAR1) and influencing the downstream JAK2/STAT1 signaling pathway. Knockdown of ID2‐AS1 in this context alleviates neuronal injury by enhancing cell proliferation, reducing oxidative stress and cytotoxicity, and diminishing inflammatory responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these findings suggest that ID2‐AS1 exerts its effects context‐dependently—suppressing tumor metastasis in HCC through chromatin modification and EMT regulation, while its inhibition in Parkinson’s disease models protects against neuronal injury via the miR‐199a‐5p/IFNAR1/JAK2/STAT1 axis.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yuqiang Zhou, Lin Huan, Yangjun Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA ID2-AS1 suppresses tumor metastasis by activating the HDAC8/ID2 pathway in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2019.11.007"}], "href": "https://doi.org/10.1016/j.canlet.2019.11.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31730902"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31730902"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Furong Xu, Hui Wang, Ju Tian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Down-Regulation of ID2-AS1 Alleviates the Neuronal Injury Induced by 1-Methy1-4-Phenylpyridinium in Human Neuroblastoma Cell Line SH-SY5Y Cells Through Regulating miR-199a-5p/IFNAR1/JAK2/STAT1 Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurochem Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11064-021-03356-4"}], "href": "https://doi.org/10.1007/s11064-021-03356-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34050453"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34050453"}]}]}]}