IDH1 Gene

Name	isocitrate dehydrogenase 1 (NADP+), soluble
Description	Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n IDH1 is a cytosolic, NADP⁺‐dependent isocitrate dehydrogenase that in its wild‐type form catalyzes the oxidative decarboxylation of isocitrate to generate α–ketoglutarate (α–KG) and NADPH, thereby playing a central role in cellular metabolism and redox homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": " In many cancers—notably in gliomas, secondary glioblastomas, acute myeloid leukemia, and intrahepatic cholangiocarcinomas—recurrent heterozygous mutations occur almost exclusively at arginine 132. These mutations bestow a neomorphic enzymatic activity that converts α–KG into the oncometabolite 2–hydroxyglutarate (2–HG)."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": " The accumulation of 2–HG competitively inhibits a broad class of α–KG–dependent dioxygenases—including histone demethylases and TET family enzymes—leading to widespread epigenetic alterations, aberrant histone and DNA methylation, and impaired cellular differentiation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " These metabolic and epigenetic changes contribute to tumor initiation and progression as well as to the distinctive molecular classification and prognostic stratification observed in gliomas and leukemias."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "13"}]}, {"type": "t", "text": " Moreover, preclinical studies have shown that mutant IDH1 not only alters cellular metabolism but also creates therapeutic vulnerabilities—since inhibition of the mutant enzyme can reduce 2–HG levels, partially reverse epigenetic abnormalities, and induce differentiation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "17"}]}, {"type": "t", "text": " Collectively, these studies establish that both the normal enzymatic function and the mutant neomorphic activity of IDH1—through altered metabolic flux and epigenomic reprogramming—play a pivotal role in oncogenic transformation and tumor behavior."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "18", "end_ref": "25"}, {"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "26"}, {"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Roel G W Verhaak, Katherine A Hoadley, Elizabeth Purdom, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccr.2009.12.020"}], "href": "https://doi.org/10.1016/j.ccr.2009.12.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20129251"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20129251"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hai Yan, D Williams Parsons, Genglin Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IDH1 and IDH2 mutations in gliomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "N Engl J Med (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1056/NEJMoa0808710"}], "href": "https://doi.org/10.1056/NEJMoa0808710"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19228619"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19228619"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jörg Balss, Jochen Meyer, Wolf Mueller, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of the IDH1 codon 132 mutation in brain tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Neuropathol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00401-008-0455-2"}], "href": "https://doi.org/10.1007/s00401-008-0455-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18985363"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18985363"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Koichi Ichimura, Danita M Pearson, Sylvia Kocialkowski, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuro Oncol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1215/15228517-2009-025"}], "href": "https://doi.org/10.1215/15228517-2009-025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19435942"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19435942"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Lenny Dang, David W White, Stefan Gross, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cancer-associated IDH1 mutations produce 2-hydroxyglutarate."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature08617"}], "href": "https://doi.org/10.1038/nature08617"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19935646"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19935646"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Dan Rohle, Janeta Popovici-Muller, Nicolaos Palaskas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1236062"}], "href": "https://doi.org/10.1126/science.1236062"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23558169"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23558169"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Stefan Gross, Rob A Cairns, Mark D Minden, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20092506"}], "href": "https://doi.org/10.1084/jem.20092506"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20142433"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20142433"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Wei Xu, Hui Yang, Ying Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccr.2010.12.014"}], "href": "https://doi.org/10.1016/j.ccr.2010.12.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21251613"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21251613"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Peppi Koivunen, Sungwoo Lee, Christopher G Duncan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature10898"}], "href": "https://doi.org/10.1038/nature10898"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22343896"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22343896"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "D Williams Parsons, Siân Jones, Xiaosong Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An integrated genomic analysis of human glioblastoma multiforme."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1164382"}], "href": "https://doi.org/10.1126/science.1164382"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18772396"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18772396"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Marc Sanson, Yannick Marie, Sophie Paris, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Isocitrate dehydrogenase 1 codon 132 mutation is an important prognostic biomarker in gliomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Oncol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1200/JCO.2009.21.9832"}], "href": "https://doi.org/10.1200/JCO.2009.21.9832"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19636000"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19636000"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Sumihito Nobusawa, Takuya Watanabe, Paul Kleihues, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IDH1 mutations as molecular signature and predictive factor of secondary glioblastomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-09-0715"}], "href": "https://doi.org/10.1158/1078-0432.CCR-09-0715"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19755387"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19755387"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yuchen Jiao, Timothy M Pawlik, Robert A Anders, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.2813"}], "href": "https://doi.org/10.1038/ng.2813"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24185509"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24185509"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Daniel J Brat, Roel G W Verhaak, Kenneth D Aldape, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Insulator dysfunction and oncogene activation in IDH mutant gliomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature16490"}], "href": "https://doi.org/10.1038/nature16490"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26700815"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26700815"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Christian Hartmann, Bettina Hentschel, Wolfgang Wick, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Patients with IDH1 wild type anaplastic astrocytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: implications for classification of gliomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Neuropathol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00401-010-0781-z"}], "href": "https://doi.org/10.1007/s00401-010-0781-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21088844"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21088844"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Michael Weller, Jörg Felsberg, Christian Hartmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular predictors of progression-free and overall survival in patients with newly diagnosed glioblastoma: a prospective translational study of the German Glioma Network."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Oncol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1200/JCO.2009.23.0805"}], "href": "https://doi.org/10.1200/JCO.2009.23.0805"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19805672"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19805672"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Maria E Figueroa, Omar Abdel-Wahab, Chao Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccr.2010.11.015"}], "href": "https://doi.org/10.1016/j.ccr.2010.11.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21130701"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21130701"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Patrick S Ward, Jay Patel, David R Wise, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccr.2010.01.020"}], "href": "https://doi.org/10.1016/j.ccr.2010.01.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20171147"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20171147"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Timothy J Ley, Li Ding, Matthew J Walter, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1170944"}], "href": "https://doi.org/10.1126/science.1170944"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19359588"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19359588"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Takuya Watanabe, Sumihito Nobusawa, Paul Kleihues, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2353/ajpath.2009.080958"}], "href": "https://doi.org/10.2353/ajpath.2009.080958"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19246647"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19246647"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "M Fernanda Amary, Krisztian Bacsi, Francesca Maggiani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Pathol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/path.2913"}], "href": "https://doi.org/10.1002/path.2913"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21598255"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21598255"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Peter Paschka, Richard F Schlenk, Verena I Gaidzik, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Oncol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1200/JCO.2010.28.3762"}], "href": "https://doi.org/10.1200/JCO.2010.28.3762"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20567020"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20567020"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Guido Marcucci, Kati Maharry, Yue-Zhong Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Oncol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1200/JCO.2009.27.3730"}], "href": "https://doi.org/10.1200/JCO.2009.27.3730"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20368543"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20368543"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Elaine R Mardis, Li Ding, David J Dooling, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Recurring mutations found by sequencing an acute myeloid leukemia genome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "N Engl J Med (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1056/NEJMoa0903840"}], "href": "https://doi.org/10.1056/NEJMoa0903840"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19657110"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19657110"}]}]}]}
Synonyms	HEL-S-26, IDCD, PICD, IDH, HEL-216, IDP, IDPC
Proteins	IDHC_HUMAN
NCBI Gene ID	3417
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

IDH1 has 15,199 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 136 datasets.

Click the + buttons to view associations for IDH1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

IDH1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by IDH1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of IDH1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of IDH1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of IDH1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of IDH1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of IDH1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of IDH1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of IDH1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of IDH1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of IDH1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of IDH1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of IDH1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of IDH1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with IDH1 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with IDH1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with IDH1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of IDH1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of IDH1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of IDH1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with IDH1 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing IDH1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of IDH1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing IDH1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing IDH1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with IDH1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with IDH1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing IDH1 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with IDH1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with IDH1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with IDH1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of IDH1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by IDH1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving IDH1 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving IDH1 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with IDH1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with IDH1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with IDH1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with IDH1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with IDH1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for IDH1 protein from the curated DrugBank Drug Targets dataset.