{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent work has uncovered a novel role for an uncharacterized protein—referred to as IFTAP (encoded by C11ORF74)—in the regulation of ciliary protein trafficking. In vertebrate cells, IFTAP interacts specifically with the intraflagellar transport‐A (IFT‐A) complex via its IFT122 subunit. At least a sub‐population of IFTAP molecules is transported in a retrograde manner toward the distal tip of the cilium, as evidenced by their accumulation at the tip under conditions where an IFT‐A subunit (IFT139) is absent."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Functionally, IFTAP appears to facilitate the proper entry of the BBSome complex into cilia. In IFTAP knockout cells, although ciliary trafficking of certain G‐protein–coupled receptors (such as Smoothened and GPR161) remains intact, BBSome components are excluded from the ciliary compartment. This suggests that IFTAP plays a selective role, acting as a regulatory accessory that fine‐tunes the delivery of specific ciliary cargoes rather than serving as a core component of the bidirectional intraflagellar transport machinery.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Although the overall impact of IFTAP on ciliogenesis and Hedgehog signaling appears limited, its evolutionary conservation among vertebrates points to a specialized, perhaps context‐dependent, role in modulating ciliary composition and function. Further studies aimed at complete inactivation and functional dissection of IFTAP will be necessary to fully elucidate its transcriptional and posttranscriptional contributions within ciliated cells.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Mariko Takahara, Masataka Kunii, Kentaro Nakamura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "C11ORF74 interacts with the IFT-A complex and participates in ciliary BBSome localization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jb/mvy100"}], "href": "https://doi.org/10.1093/jb/mvy100"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30476139"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30476139"}]}]}]}