{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n IGBP1‐AS1 plays distinct roles in tumorigenesis in a cancer‐type–dependent manner. In breast cancer, IGBP1‐AS1 is significantly downregulated, and its overexpression suppresses cell proliferation and invasion, thereby improving patient survival outcomes. Mechanistically, IGBP1‐AS1 functions by modulating the miR‐24‐1/ZIC3 axis, which ultimately restricts tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In contrast, in nasopharyngeal carcinoma, IGBP1‐AS1 is markedly upregulated. Its knockdown impairs tumor progression through the regulation of miR‐150‐5p and subsequent control of ZEB1 expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " These findings indicate that IGBP1‐AS1 may serve as a promising biomarker and therapeutic target, albeit with cancer‐specific regulatory mechanisms.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Deqin Chen, Yangfan Fan, Fang Wan "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA IGBP1-AS1/miR-24-1/ZIC3 loop regulates the proliferation and invasion ability in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12935-020-01214-x"}], "href": "https://doi.org/10.1186/s12935-020-01214-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32390766"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32390766"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Li-Jun Wang, Yan-Sheng Wang, Ying Zhao "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA IGBP1-AS1 targets miR-150-5p to increase ZEB1 expression in nasopharyngeal carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Cancer Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.21037/tcr-22-291"}], "href": "https://doi.org/10.21037/tcr-22-291"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35402187"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35402187"}]}]}]}