{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n IGF2BP2‐AS1 appears to participate in cancer progression by modulating key cellular processes associated with tumor growth and metastasis. In oral squamous cell carcinoma, IGF2BP2‐AS1 is highly expressed and is primarily localized in the cytoplasm, suggesting a role in post‐transcriptional regulation. Its elevated expression is linked to poor patient survival, and functional studies indicate that IGF2BP2‐AS1 promotes cell proliferation and migration while inhibiting apoptosis. Mechanistically, knockdown of this lncRNA leads to cell‐cycle arrest and apoptosis, with concurrent downregulation of oncogenic proteins such as β‐catenin, Cyclin D1, Bcl‑2, and MMP2, and upregulation of the pro‐apoptotic factor Bax. Moreover, the inhibitory effects of IGF2BP2‐AS1 knockdown can be partially reversed by stimulation of the Wnt/β‑catenin pathway, underscoring its involvement in this signaling cascade."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In contrast, in lung squamous cell carcinoma, alterations in IGF2BP2‐AS1 have been associated with improved overall survival, suggesting that its prognostic impact may be context‐dependent. This finding, derived from integrated genomic analyses across lung cancer types, highlights the complexity of lncRNA functions and their potential as biomarkers or therapeutic targets in distinct tumor settings."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shuqing Tong, Xiaoyang Wang, Xiangrui Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of lncRNA IGF2BP2-AS1 inhibits proliferation and migration of oral squamous cell carcinoma cells via the Wnt/β-catenin pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Oral Pathol Med (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jop.13248"}], "href": "https://doi.org/10.1111/jop.13248"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34637162"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34637162"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Bing Liu, Yifei Chen, Jiong Yang "}, {"type": "b", "children": [{"type": "t", "text": "LncRNAs are altered in lung squamous cell carcinoma and lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.13651"}], "href": "https://doi.org/10.18632/oncotarget.13651"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27903974"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27903974"}]}]}]}