IGFBP5 Gene

Name	insulin-like growth factor binding protein 5
Description	Enables insulin-like growth factor I binding activity and receptor ligand activity. Involved in several processes, including cellular response to cAMP; regulation of smooth muscle cell migration; and regulation of smooth muscle cell proliferation. Part of insulin-like growth factor ternary complex. Biomarker of pulmonary fibrosis. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Insulin‐like growth factor binding protein‑5 (IGFBP5) has emerged as a multifunctional modulator of insulin‐like growth factor (IGF) bioactivity with context‐dependent roles in cell growth, differentiation, survival, and tissue remodeling. In cancer, IGFBP5 appears to have dual roles. In certain settings, such as in prostate cancer models with NANOG overexpression and in cells harboring a Vgll1–TEAD complex, IGFBP5 is up‐regulated and promotes proliferation and anchorage‐independent growth (see"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "). In contrast, functional studies in human breast cancer and osteosarcoma cells indicate that overexpression of IGFBP5 induces G2/M arrest and apoptosis, thereby inhibiting tumor cell growth and metastatic progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In osteoarthritis chondrocytes, IGFBP5 is directly targeted by microRNA‑140, and its regulation appears to contribute to disease‐related changes in extracellular matrix turnover."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Moreover, in idiopathic pulmonary fibrosis, enhanced IGFBP5 expression in lung fibroblasts is associated with extracellular matrix production and may help perpetuate fibrotic processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Developmentally, proteolytic processing of IGFBP5 is critical for regulating IGF availability. A mutated isoform of MASP1 that impairs IGFBP5 processing has been linked to craniofacial and musculoskeletal anomalies"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ", and derepression of IGFBP5 in the mesenchymal compartment negatively affects epithelial regeneration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " In bone, IGFBP5 can inhibit osteoblast differentiation by blocking IGF‑stimulated PI3‑kinase/Akt signaling, thereby impairing BMP2‐mediated osteogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Similarly, in cardiac tissues, Akt activation elevates IGFBP5 expression, which may contribute to cardiomyocyte survival"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ", whereas in endothelial and dermal cells IGFBP5 overexpression can trigger premature senescence via a p53‐dependent pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In myogenic cells, IGFBP5 is among the target genes induced by MyoD and Myf5 during the proliferative phase"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": ", and in thyroid cancer cells, suppression of IGFBP5 by microRNA‑204‑5p reduces cell proliferation, supporting an oncogenic role in that setting."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": " Furthermore, failure to process IGFBP5 due to mutations in the protease PAPP‑A2 leads to reduced free IGF‑I and consequent growth failure, underscoring its importance in regulating systemic IGF action during development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": " Finally, sustained overexpression of IGFBP5 in the mammary gland disrupts normal development by attenuating IGF‑I receptor activation, increasing pro‐apoptotic markers, and impairing cell proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies highlight that IGFBP5 functions as a critical regulator of IGF signaling with diverse roles ranging from modulation of cell proliferation and apoptotic balance in cancer to influencing differentiation, tissue remodeling, and senescence in various tissues."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_fs", "start_ref": "5", "end_ref": "12"}, {"type": "fg_f", "ref": "2"}, {"type": "fg_f", "ref": "14"}, {"type": "fg_f", "ref": "13"}, {"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "C R Jeter, B Liu, X Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NANOG promotes cancer stem cell characteristics and prostate cancer resistance to androgen deprivation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2011.114"}], "href": "https://doi.org/10.1038/onc.2011.114"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21499299"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21499299"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ajaybabu V Pobbati, Siew Wee Chan, Ian Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural and functional similarity between the Vgll1-TEAD and the YAP-TEAD complexes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Structure (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.str.2012.04.004"}], "href": "https://doi.org/10.1016/j.str.2012.04.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22632831"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22632831"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Alison J Butt, Kristie A Dickson, Fiona McDougall, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Insulin-like growth factor-binding protein-5 inhibits the growth of human breast cancer cells in vitro and in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M301965200"}], "href": "https://doi.org/10.1074/jbc.M301965200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12777377"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12777377"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Y Su, E R Wagner, Q Luo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Insulin-like growth factor binding protein 5 suppresses tumor growth and metastasis of human osteosarcoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2011.97"}], "href": "https://doi.org/10.1038/onc.2011.97"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21460855"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21460855"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Ginette Tardif, David Hum, Jean-Pierre Pelletier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Musculoskelet Disord (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2474-10-148"}], "href": "https://doi.org/10.1186/1471-2474-10-148"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19948051"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19948051"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Joseph M Pilewski, Lixin Liu, Adam C Henry, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Insulin-like growth factor binding proteins 3 and 5 are overexpressed in idiopathic pulmonary fibrosis and contribute to extracellular matrix deposition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/S0002-9440(10)62263-8"}], "href": "https://doi.org/10.1016/S0002-9440(10"}, {"type": "t", "text": "62263-8) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15681824"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15681824"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Caroline Rooryck, Anna Diaz-Font, Daniel P S Osborn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in lectin complement pathway genes COLEC11 and MASP1 cause 3MC syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.757"}], "href": "https://doi.org/10.1038/ng.757"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21258343"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21258343"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Raghu R Chivukula, Guanglu Shi, Asha Acharya, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An essential mesenchymal function for miR-143/145 in intestinal epithelial regeneration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2014.03.055"}], "href": "https://doi.org/10.1016/j.cell.2014.03.055"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24855947"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24855947"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Aditi Mukherjee, Peter Rotwein "}, {"type": "b", "children": [{"type": "t", "text": "Akt promotes BMP2-mediated osteoblast differentiation and bone development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.042770"}], "href": "https://doi.org/10.1242/jcs.042770"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19208758"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19208758"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Stuart A Cook, Takashi Matsui, Ling Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptional effects of chronic Akt activation in the heart."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M201462200"}], "href": "https://doi.org/10.1074/jbc.M201462200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11956204"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11956204"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Kwang Seok Kim, Young Bae Seu, Suk-Hwan Baek, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Induction of cellular senescence by insulin-like growth factor binding protein-5 through a p53-dependent mechanism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e07-03-0280"}], "href": "https://doi.org/10.1091/mbc.e07-03-0280"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17804819"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17804819"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Jeff Ishibashi, Robert L Perry, Atsushi Asakura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MyoD induces myogenic differentiation through cooperation of its NH2- and COOH-terminal regions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200502101"}], "href": "https://doi.org/10.1083/jcb.200502101"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16275751"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16275751"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Lianyong Liu, Jingnan Wang, Xiangqi Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-204-5p suppresses cell proliferation by inhibiting IGFBP5 in papillary thyroid carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2015.01.037"}], "href": "https://doi.org/10.1016/j.bbrc.2015.01.037"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25603050"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25603050"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Andrew Dauber, María T Muñoz-Calvo, Vicente Barrios, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in pregnancy-associated plasma protein A2 cause short stature due to low IGF-I availability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Mol Med (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/emmm.201506106"}], "href": "https://doi.org/10.15252/emmm.201506106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26902202"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26902202"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Elizabeth Tonner, Michael C Barber, Gordon J Allan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Insulin-like growth factor binding protein-5 (IGFBP-5) induces premature cell death in the mammary glands of transgenic mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.129.19.4547"}], "href": "https://doi.org/10.1242/dev.129.19.4547"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12223411"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12223411"}]}]}]}
Synonyms	IBP5
Proteins	IBP5_HUMAN
NCBI Gene ID	3488
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

IGFBP5 has 19,105 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 123 datasets.

Click the + buttons to view associations for IGFBP5 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

IGFBP5 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by IGFBP5 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of IGFBP5 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of IGFBP5 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of IGFBP5 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of IGFBP5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of IGFBP5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of IGFBP5 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of IGFBP5 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of IGFBP5 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of IGFBP5 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of IGFBP5 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of IGFBP5 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of IGFBP5 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with IGFBP5 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with IGFBP5 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with IGFBP5 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of IGFBP5 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of IGFBP5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of IGFBP5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing IGFBP5 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of IGFBP5 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing IGFBP5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing IGFBP5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with IGFBP5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with IGFBP5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with IGFBP5 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with IGFBP5 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with IGFBP5 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of IGFBP5 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by IGFBP5 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with IGFBP5 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with IGFBP5 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with IGFBP5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with IGFBP5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with IGFBP5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with IGFBP5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at IGFBP5 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of IGFBP5 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of IGFBP5 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing IGFBP5 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.