{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n IGFBP7‐AS1 is a long noncoding RNA that appears to function as a critical regulator in diverse cellular contexts, particularly in tumorigenesis and differentiation. In Epstein–Barr virus (EBV)‐associated malignancies such as B‐cell lymphoma, IGFBP7‐AS1 expression is downregulated by EBV infection, thereby disrupting its normal tumor‐suppressive role. Under physiological conditions, the tumor suppressor p53 transcriptionally activates IGFBP7‐AS1, which in turn stabilizes IGFBP7 mRNA through formation of an overlapping duplex. The resultant p53/IGFBP7‐AS1/IGFBP7 axis promotes cellular apoptosis and inhibits proliferation by modulating downstream signaling pathways including the cGMP‐PKG cascade and reducing secretion of pro‐tumorigenic factors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In glioblastoma, elevated levels of IGFBP7‐AS1 are incorporated into an lncRNA signature that robustly stratifies patient outcomes. Bioinformatics analyses have linked higher IGFBP7‐AS1 expression to enrichment of epithelial–mesenchymal transition and p53 pathway genes, and functional studies indicate that IGFBP7‐AS1 supports glioma cell viability, migration, and invasion, underscoring its potential role in tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, emerging evidence from dental tissue engineering research suggests that IGFBP7‐AS1 may participate in the odontogenic differentiation of stem cells derived from human exfoliated deciduous teeth, hinting at broader roles in cellular differentiation and tissue regeneration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Additionally, IGFBP7‐AS1 is among a spectrum of host lncRNAs modulated by EBV‐encoded products, further emphasizing its involvement in the complex interplay between viral infection and host gene regulation in tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wei Dang, Pengfei Cao, Qijia Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IGFBP7-AS1 is a p53-responsive long noncoding RNA downregulated by Epstein-Barr virus that contributes to viral tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2021.10.006"}], "href": "https://doi.org/10.1016/j.canlet.2021.10.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34634383"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34634383"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Depei Li, Jie Lu, Hong Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a long noncoding RNA signature to predict outcomes of glioblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2019.10184"}], "href": "https://doi.org/10.3892/mmr.2019.10184"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31059035"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31059035"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Dan Wang, Ningxin Zhu, Fei Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA IGFBP7-AS1 Promotes Odontogenesis of Stem Cells from Human Exfoliated Deciduous Teeth via the p38 MAPK Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cells Int (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2022/9227248"}], "href": "https://doi.org/10.1155/2022/9227248"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35469296"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35469296"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yitong Liu, Zhizhong Hu, Yang Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNAs in Epstein-Barr virus-related cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell Int (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12935-021-01986-w"}], "href": "https://doi.org/10.1186/s12935-021-01986-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34034760"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34034760"}]}]}]}