IGKV@ Gene

Name immunoglobulin kappa variable cluster
Description Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains (see MIM 147100) and 2 identical light chains, either kappa or lambda (see MIM 147220), joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. The kappa and lambda light chains have no apparent functional differences. Each Ig kappa light chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by a C region gene (IGKC; MIM 147200), that provides signaling functions. The kappa light chain V region is encoded by 2 types of genes: V genes and joining (J) genes (see MIM 146970). Random selection of just 1 gene of each type to assemble a V region accounts for the great diversity of V regions among Ig molecules. The kappa light chain locus on chromosome 2 contains approximately 40 functional V genes, followed by approximately 5 functional J genes. Due to polymorphism, the numbers of functional V and J genes differ among individuals (Janeway et al., 2005).[supplied by OMIM, Apr 2008]
Synonyms IGKV, IGKV2, IGKV2@, IGKV1@, IGKV3, IGKV3@, IGKV1
NCBI Gene ID 3519
API
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Predicted Functions View IGKV@'s ARCHS4 Predicted Functions.
Co-expressed Genes View IGKV@'s ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View IGKV@'s ARCHS4 Predicted Functions.

Functional Associations

IGKV@ has 23 functional associations with biological entities spanning 2 categories (disease, phenotype or trait, functional term, phrase or reference) extracted from 4 datasets.

Click the + buttons to view associations for IGKV@ from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
GAD Gene-Disease Associations diseases associated with IGKV@ gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
GAD High Level Gene-Disease Associations diseases associated with IGKV@ gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with IGKV@ gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
HuGE Navigator Gene-Phenotype Associations phenotypes associated with IGKV@ gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.