{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n IL12A‑AS1 is an antisense long noncoding RNA that has been implicated as a susceptibility gene in Behçet’s disease. In a genome‐wide association study involving an Iranian cohort, a variant within IL12A‑AS1 (rs17810546) was significantly associated with disease risk, supporting its role in modulating immune responses pertinent to the pathogenesis of Behçet’s disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " \n Although subsequent large‐scale multiethnic genetic investigations have identified additional risk loci for Behçet’s disease, the confirmed association of IL12A‑AS1 underscores the importance of noncoding RNAs in the genetic regulation of inflammatory pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its genetic association with Behçet’s disease, recent transcriptional and epigenetic analyses during fungal infections have highlighted the broader immunomodulatory functions of long noncoding RNAs—including antisense RNAs—in regulating chemokine and cytokine signaling. This functional perspective suggests that IL12A‑AS1 may participate in fine‐tuning immune responses, thus representing a promising target for future research into therapeutic interventions for inflammatory conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Inês Sousa, Farhad Shahram, David Francisco, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Brief report: association of CCR1, KLRC4, IL12A-AS1, STAT4, and ERAP1 With Behçet's disease in Iranians."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arthritis Rheumatol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/art.39240"}], "href": "https://doi.org/10.1002/art.39240"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26097239"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26097239"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Lourdes Ortiz Fernández, Patrick Coit, Vuslat Yilmaz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic Association of a Gain-of-Function IFNGR1 Polymorphism and the Intergenic Region LNCAROD/DKK1 With Behçet's Disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arthritis Rheumatol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/art.41637"}], "href": "https://doi.org/10.1002/art.41637"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33393726"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33393726"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Konstantin Riege, Martin Hölzer, Tilman E Klassert, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Massive Effect on LncRNAs in Human Monocytes During Fungal and Bacterial Infections and in Response to Vitamins A and D."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep40598"}], "href": "https://doi.org/10.1038/srep40598"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28094339"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28094339"}]}]}]}