IL6R Gene

HGNC Family	Interleukin receptors, CD molecules (CD), Immunoglobulin superfamily domain containing
Name	interleukin 6 receptor
Description	This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been identified in this gene. A pseudogene of this gene is found on chromosome 9. [provided by RefSeq, Aug 2020]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Interleukin‑6 receptor (IL6R) is a central mediator of IL‑6 signaling that operates via two distinct modes. In classic signaling, membrane‐bound IL6R (in conjunction with the signal‐transducing subunit gp130) promotes regenerative and anti‑bacterial responses, whereas in trans‑signaling the soluble form of IL6R confers pro‑inflammatory properties to virtually all cell types expressing gp130."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the oncologic context, IL6R engagement activates downstream STAT transcription factors that contribute to cancer progression. In colorectal cancer, for example, IL6R is a component of a feedback loop with STAT3 and miR‑34a that promotes epithelial–mesenchymal transition (EMT) and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Similarly, in cervical cancer, IL6R‐mediated signal transduction via STAT3 triggers upregulation of vascular endothelial growth factor (VEGF), thereby stimulating tumor angiogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In aggressive tumors such as glioblastoma and triple‑negative breast cancer, high expression of IL6R on cancer stem cells or within the tumor microenvironment sustains STAT3‑dependent survival, invasion, and stemness."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its roles in cancer, genetic studies have identified common variants in the IL6R gene that influence circulating levels of inflammatory markers such as C‑reactive protein, underscoring its involvement in systemic inflammatory and metabolic regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " In the musculoskeletal system, IL6R signaling in concert with IL‑6 modulates bone resorption by regulating the expression of RANKL and osteoprotegerin in osteoclasts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In immune regulation, IL‑6 signals via IL6R to direct T cell differentiation, including the generation of T follicular helper cells, through activation of STAT1 and STAT3 pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " Moreover, IL6R signaling in myeloid cells is critical for alternative macrophage polarization, a process that can limit insulin resistance and inflammation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": " The therapeutic potential of IL6R blockade is highlighted by the successful use of anti‑IL6R agents (e.g., tocilizumab) in treating inflammatory diseases and emerging strategies in oncology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies demonstrate that IL6R functions as a versatile receptor orchestrating multiple context‑dependent processes—from directing immune cell fate and maintaining bone homeostasis to driving tumor progression and angiogenesis—making it a promising target for therapeutic intervention in inflammatory, metabolic, and oncologic diseases.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Janina Wolf, Stefan Rose-John, Christoph Garbers "}, {"type": "b", "children": [{"type": "t", "text": "Interleukin-6 and its receptors: a highly regulated and dynamic system."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cytokine (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cyto.2014.05.024"}], "href": "https://doi.org/10.1016/j.cyto.2014.05.024"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24986424"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24986424"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Fred Schaper, Stefan Rose-John "}, {"type": "b", "children": [{"type": "t", "text": "Interleukin-6: Biology, signaling and strategies of blockade."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cytokine Growth Factor Rev (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cytogfr.2015.07.004"}], "href": "https://doi.org/10.1016/j.cytogfr.2015.07.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26189695"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26189695"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Matjaz Rokavec, Meryem Gülfem Öner, Huihui Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI73531"}], "href": "https://doi.org/10.1172/JCI73531"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24642471"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24642471"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Maria Hatziapostolou, Christos Polytarchou, Eleni Aggelidou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An HNF4α-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2011.10.043"}], "href": "https://doi.org/10.1016/j.cell.2011.10.043"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22153071"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22153071"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Qing Xu, Jon Briggs, Sungman Park, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1208719"}], "href": "https://doi.org/10.1038/sj.onc.1208719"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16007214"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16007214"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Lin-Hung Wei, Min-Liang Kuo, Chi-An Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1206226"}], "href": "https://doi.org/10.1038/sj.onc.1206226"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12629515"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12629515"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Hui Wang, Justin D Lathia, Qiulian Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cells (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/stem.188"}], "href": "https://doi.org/10.1002/stem.188"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19658188"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19658188"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yueh-Shan Weng, Hong-Yu Tseng, Yen-An Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MCT-1/miR-34a/IL-6/IL-6R signaling axis promotes EMT progression, cancer stemness and M2 macrophage polarization in triple-negative breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12943-019-0988-0"}], "href": "https://doi.org/10.1186/s12943-019-0988-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30885232"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30885232"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Paul Elliott, John C Chambers, Weihua Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "JAMA (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1001/jama.2009.954"}], "href": "https://doi.org/10.1001/jama.2009.954"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19567438"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19567438"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "David Melzer, John R B Perry, Dena Hernandez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A genome-wide association study identifies protein quantitative trait loci (pQTLs)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1000072"}], "href": "https://doi.org/10.1371/journal.pgen.1000072"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18464913"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18464913"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Py Palmqvist, Emma Persson, H Herschel Conaway, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IL-6, leukemia inhibitory factor, and oncostatin M stimulate bone resorption and regulate the expression of receptor activator of NF-kappa B ligand, osteoprotegerin, and receptor activator of NF-kappa B in mouse calvariae."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.169.6.3353"}], "href": "https://doi.org/10.4049/jimmunol.169.6.3353"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12218157"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12218157"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Markus F Neurath, Susetta Finotto "}, {"type": "b", "children": [{"type": "t", "text": "IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cytokine Growth Factor Rev (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cytogfr.2011.02.003"}], "href": "https://doi.org/10.1016/j.cytogfr.2011.02.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21377916"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21377916"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Youn Soo Choi, Danelle Eto, Jessica A Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cutting edge: STAT1 is required for IL-6-mediated Bcl6 induction for early follicular helper cell differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1203032"}], "href": "https://doi.org/10.4049/jimmunol.1203032"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23447690"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23447690"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Jan Mauer, Bhagirath Chaurasia, Julia Goldau, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Immunol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ni.2865"}], "href": "https://doi.org/10.1038/ni.2865"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24681566"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24681566"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Jean-François Rossi, Zhao-Yang Lu, Michel Jourdan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interleukin-6 as a therapeutic target."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-14-2291"}], "href": "https://doi.org/10.1158/1078-0432.CCR-14-2291"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25589616"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25589616"}]}]}]}
Synonyms	CD126, GP80, IL6Q, IL6RQ, IL-6RA, IL-6R-1, IL6RA
Proteins	IL6RA_HUMAN
NCBI Gene ID	3570
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

IL6R has 10,413 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 119 datasets.

Click the + buttons to view associations for IL6R from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

IL6R Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by IL6R gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of IL6R gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of IL6R gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of IL6R gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of IL6R gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of IL6R gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving IL6R protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of IL6R gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of IL6R gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of IL6R gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of IL6R gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of IL6R gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with IL6R gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of IL6R gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of IL6R gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of IL6R gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of IL6R gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing IL6R protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing IL6R protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with IL6R protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with IL6R protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of IL6R gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with IL6R gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with IL6R gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with IL6R gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with IL6R gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by IL6R gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving IL6R gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving IL6R gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with IL6R gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with IL6R gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with IL6R gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with IL6R gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with IL6R gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with IL6R gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for IL6R protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at IL6R gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of IL6R gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of IL6R gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing IL6R from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.