{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ILF3‐AS1 is a long non‐coding RNA with context‐dependent functions that have been implicated in a wide range of human diseases, particularly in cancer. In several malignancies – including melanoma, osteosarcoma, hepatocellular carcinoma, retinoblastoma, nasopharyngeal carcinoma, gastric cancer, colorectal cancer, breast cancer, papillary thyroid carcinoma and colon adenocarcinoma – ILF3‐AS1 is frequently upregulated and functions as an oncogenic driver by promoting cell proliferation, migration, invasion and by inhibiting apoptosis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "11"}]}, {"type": "t", "text": " In many of these studies, ILF3‐AS1 has been shown to promote oncogenic processes through multiple mechanisms. It interacts with regulatory proteins – such as recruiting or stabilizing epigenetic modifiers like EZH2 and binding to ILF3 to enhance transcript stability – and also functions as a competing endogenous RNA (ceRNA) that sponges diverse microRNAs (including miR‐212, miR‐132‐3p, miR‐320a, miR‐454‐3p, miR‐29a, miR‐4429, miR‐628‐5p, miR‐493‐5p, miR‐4306 and miR‐619‐5p) to modulate downstream targets such as SOX5, SMAD2, BMI1, PTEN, PTBP3, RAB14, MEIS2, PDK1 and CAMK1D."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}, {"type": "fg_f", "ref": "2"}, {"type": "fg_f", "ref": "4"}, {"type": "fg_fs", "start_ref": "13", "end_ref": "15"}, {"type": "fg_f", "ref": "8"}, {"type": "fg_f", "ref": "16"}, {"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " In contrast, in certain contexts—such as in cervical cancer and myocardial infarction—ILF3‐AS1 appears to exert tumor‐suppressive or protective roles by inhibiting epithelial–mesenchymal transition and alleviating hypoxia‐induced injury via activation of the PI3K/Akt pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}, {"type": "fg_fs", "start_ref": "17", "end_ref": "19"}]}, {"type": "t", "text": " Furthermore, ILF3‐AS1 has been incorporated into prognostic signatures that effectively stratify patients with colon and cervical cancers according to recurrence and overall survival risk."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "20"}, {"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": " Collectively, these findings demonstrate that ILF3‐AS1 is a critical regulator of tumorigenesis and cellular homeostasis whose mechanisms—including modulation of protein partners and microRNA networks—are highly context dependent, indicating its potential utility as both a therapeutic target and a prognostic biomarker.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiangjun Chen, Sha Liu, Xiaochun Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA ILF3-AS1 promotes cell proliferation, migration, and invasion via negatively regulating miR-200b/a/429 in melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20171031"}], "href": "https://doi.org/10.1042/BSR20171031"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28935763"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28935763"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiao-Hui Hu, Jian Dai, Hou-Lai Shang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SP1-mediated upregulation of lncRNA ILF3-AS1 functions a ceRNA for miR-212 to contribute to osteosarcoma progression via modulation of SOX5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.02.110"}], "href": "https://doi.org/10.1016/j.bbrc.2019.02.110"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30819403"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30819403"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Changwen Bo, Na Li, Li He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA ILF3-AS1 facilitates hepatocellular carcinoma progression by stabilizing ILF3 mRNA in an m"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "6"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": "A-dependent manner."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Cell (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13577-021-00608-x"}], "href": "https://doi.org/10.1007/s13577-021-00608-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34491544"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34491544"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Shaoping Han, Lili Song, Yang Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The long non-coding RNA ILF3-AS1 increases the proliferation and invasion of retinoblastoma through the miR-132-3p/SMAD2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2020.112087"}], "href": "https://doi.org/10.1016/j.yexcr.2020.112087"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32407730"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32407730"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xuewen Yang, Feng Lin, Feng Gao "}, {"type": "b", "children": [{"type": "t", "text": "Up-regulated long non-coding RNA ILF3-AS1 indicates poor prognosis of nasopharyngeal carcinoma and promoted cell metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biol Markers (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1724600820955199"}], "href": "https://doi.org/10.1177/1724600820955199"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32962500"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32962500"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xiaoxue Zhang, Xianxin Xie, Kuiran Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ILF3-AS1 promotes cell proliferation and inhibits cell apoptosis of breast cancer by binding with miR-4429 to upregulate RAB14."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Exp Toxicol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/0960327121989422"}], "href": "https://doi.org/10.1177/0960327121989422"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33525948"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33525948"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Sen Hong, Shiquan Li, Miaomiao Bi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA ILF3-AS1 promotes proliferation and metastasis of colorectal cancer cells by recruiting histone methylase EZH2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Ther Nucleic Acids (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.omtn.2021.04.007"}], "href": "https://doi.org/10.1016/j.omtn.2021.04.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34141456"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34141456"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Zhaohui Zeng, Qiangfeng Teng, Jinhong Xiao "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA ILF3-AS1 aggravates papillary thyroid carcinoma progression via regulating the miR-4306/PLAGL2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell Int (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12935-021-01950-8"}], "href": "https://doi.org/10.1186/s12935-021-01950-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34176471"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34176471"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Guozhen Gao, Wenjun Li, Sha Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The positive feedback loop between ILF3 and lncRNA ILF3-AS1 promotes melanoma proliferation, migration, and invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Manag Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/CMAR.S186777"}], "href": "https://doi.org/10.2147/CMAR.S186777"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30588088"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30588088"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Wen Q Huang, Qian R Zhuang, Zhi J He "}, {"type": "b", "children": [{"type": "t", "text": "ILF3-AS1 promotes the aerobic glycolysis and proliferation of melanoma cells by regulating miR-493-5p/PDK1 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ital J Dermatol Venerol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.23736/S2784-8671.21.06906-6"}], "href": "https://doi.org/10.23736/S2784-8671.21.06906-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33913671"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33913671"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Wei Liu, Shan Li "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA ILF3-AS1 Promotes the Progression of Colon Adenocarcinoma Cells Through the miR-619-5p/CAMK1D Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Onco Targets Ther (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/OTT.S296441"}], "href": "https://doi.org/10.2147/OTT.S296441"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33737811"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33737811"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Xiaodong Cai, Ling Long, Chao Zeng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA ILF3-AS1 mediated the occurrence of epilepsy through suppressing hippocampal miR-212 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.103148"}], "href": "https://doi.org/10.18632/aging.103148"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32404536"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32404536"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Linmei Zhu, Ruixia Chen, Chunlin Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mechanism underlying long non‑coding RNA ILF3‑AS1‑mediated inhibition of cervical cancer cell proliferation, invasion and migration, and promotion of apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2021.12193"}], "href": "https://doi.org/10.3892/mmr.2021.12193"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34080029"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34080029"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Zhen-Hu Ren, Gao-Pan Shang, Kun Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "WGCNA Co-Expression Network Analysis Reveals ILF3-AS1 Functions as a CeRNA to Regulate PTBP1 Expression by Sponging miR-29a in Gastric Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2020.00039"}], "href": "https://doi.org/10.3389/fgene.2020.00039"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32117452"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32117452"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Xiangbo Chen, Wenguang Liu, Bao Liu "}, {"type": "b", "children": [{"type": "t", "text": "Ginsenoside Rh7 Suppresses Proliferation, Migration and Invasion of NSCLC Cells Through Targeting ILF3-AS1 Mediated miR-212/SMAD1 Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2021.656132"}], "href": "https://doi.org/10.3389/fonc.2021.656132"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33996578"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33996578"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Guangxin Yan, Zhihui Chang, Chuanzhuo Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA ILF3-AS1 promotes cell migration, invasion and EMT process in hepatocellular carcinoma via the miR-628-5p/MEIS2 axis to activate the Notch pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dig Liver Dis (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.dld.2021.04.036"}], "href": "https://doi.org/10.1016/j.dld.2021.04.036"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34053876"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34053876"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "J-Y Zhang, Z Yang, K Fang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA ILF3-AS1 regulates myocardial infarction via the miR-212-3p/SIRT1 axis and PI3K/Akt signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202003_20534"}], "href": "https://doi.org/10.26355/eurrev_202003_20534"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32196615"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32196615"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Wenjuan Wu, Jing Sui, Tong Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrated analysis of two-lncRNA signature as a potential prognostic biomarker in cervical cancer: a study based on public database."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PeerJ (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7717/peerj.6761"}], "href": "https://doi.org/10.7717/peerj.6761"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31065456"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31065456"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Xiaogang Mao, Xiaomin Qin, Lin Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A 15-long non-coding RNA signature to improve prognosis prediction of cervical squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gynecol Oncol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ygyno.2017.12.011"}], "href": "https://doi.org/10.1016/j.ygyno.2017.12.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29525275"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29525275"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Meng Zhou, Long Hu, Zicheng Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Recurrence-Associated Long Non-coding RNA Signature for Determining the Risk of Recurrence in Patients with Colon Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Ther Nucleic Acids (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.omtn.2018.06.007"}], "href": "https://doi.org/10.1016/j.omtn.2018.06.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30195788"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30195788"}]}]}]}