| Name | inactivation escape 1 (non-protein coding) |
| Description | X chromosome inactivation provides dosage compensation for the expression level of X-linked genes from the single X in males and the two in females. This X chromosome gene is intronless and was identified because its transcription escapes X inactivation in females. This gene does not make a protein.[provided by RefSeq, May 2010] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n INE1 exhibits multifaceted roles that span both human disease and genome evolution. In prostate cancer, INE1 is expressed as a long non‐coding RNA that is part of an autophagy‐associated prognostic signature, with its altered expression independently correlating with patient survival outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In Drosophila, the same sequence—often referred to as DINE‑1—is one of the most abundant non‐autonomous transposable elements. These elements have undergone recurrent cycles of transposition and divergence, contributing to gene duplications and broader genome restructuring that influence the evolution of gene architecture."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, Drosophila produces stable intronic sequence RNAs (sisRNAs) derived from INE1 sequences. Their levels are tightly regulated by the RNA‐binding protein DIP1, with additional factors (such as Dsn) protecting nascent INE1‐containing transcripts from premature degradation. This regulation is crucial for maintaining proper germline stem cell homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Finally, mapping analyses in human X‐chromosomal regions have identified an “inactivation‐escape‐1” (INE1) gene within a gene‐rich segment. Although its precise function remains to be fully elucidated, its location suggests that it may contribute to regulatory processes that allow certain genes to escape X‐chromosome inactivation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these studies underscore the evolutionary and functional complexity of INE1, revealing its dual roles as both a regulatory non‐coding RNA marker in human disease and as a dynamic transposable element that shapes genomic organization and gene regulation across species.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jun Li, Hong Du, Wenqiang Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of potential autophagy-associated lncRNA in prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.202997"}], "href": "https://doi.org/10.18632/aging.202997"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33971627"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33971627"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jainy Thomas, Komal Vadnagara, Ellen J Pritham "}, {"type": "b", "children": [{"type": "t", "text": "DINE-1, the highest copy number repeats in Drosophila melanogaster are non-autonomous endonuclease-encoding rolling-circle transposable elements (Helentrons)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mob DNA (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1759-8753-5-18"}], "href": "https://doi.org/10.1186/1759-8753-5-18"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24959209"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24959209"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Hsiao-Pei Yang, Daniel A Barbash "}, {"type": "b", "children": [{"type": "t", "text": "Abundant and species-specific DINE-1 transposable elements in 12 Drosophila genomes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genome Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/gb-2008-9-2-r39"}], "href": "https://doi.org/10.1186/gb-2008-9-2-r39"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18291035"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18291035"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Galina L Kogan, Lev A Usakin, Sergei S Ryazansky, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expansion and evolution of the X-linked testis specific multigene families in the melanogaster species subgroup."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0037738"}], "href": "https://doi.org/10.1371/journal.pone.0037738"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22649555"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22649555"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jun Wang, Peter D Keightley, Daniel L Halligan "}, {"type": "b", "children": [{"type": "t", "text": "Effect of divergence time and recombination rate on molecular evolution of Drosophila INE-1 transposable elements and other candidates for neutrally evolving sites."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Evol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00239-007-9028-6"}], "href": "https://doi.org/10.1007/s00239-007-9028-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17896069"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17896069"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jing Ting Wong, Farzanah Akhbar, Amanda Yunn Ee Ng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DIP1 modulates stem cell homeostasis in Drosophila through regulation of sisR-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-017-00684-4"}], "href": "https://doi.org/10.1038/s41467-017-00684-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28970471"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28970471"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Mandy Li-Ian Tay, Jun Wei Pek "}, {"type": "b", "children": [{"type": "t", "text": "SON protects nascent transcripts from unproductive degradation by counteracting DIP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1008498"}], "href": "https://doi.org/10.1371/journal.pgen.1008498"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31730657"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31730657"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Dawn L Thiselton, Jennifer McDowall, Oliver Brandau, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An integrated, functionally annotated gene map of the DXS8026-ELK1 interval on human Xp11.3-Xp11.23: potential hotspot for neurogenetic disorders."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genomics (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1006/geno.2002.6733"}], "href": "https://doi.org/10.1006/geno.2002.6733"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11944989"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11944989"}]}]}]}
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| Synonyms | NCRNA00010 |
| Proteins | INE1_HUMAN |
| NCBI Gene ID | 8552 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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INE1 has 1,981 functional associations with biological entities spanning 7 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 39 datasets.
Click the + buttons to view associations for INE1 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of INE1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of INE1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of INE1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of INE1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of INE1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of INE1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of INE1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with INE1 gene from the CellMarker Gene-Cell Type Associations dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of INE1 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of INE1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of INE1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with INE1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of INE1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with INE1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with INE1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at INE1 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of INE1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of INE1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of INE1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing INE1 from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of INE1 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of INE1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of INE1 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of INE1 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of INE1 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of INE1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of INE1 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of INE1 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of INE1 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of INE1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of INE1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of INE1 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of INE1 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain INE1 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of INE1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of INE1 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
| Roadmap Epigenomics Cell and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of INE1 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at INE1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of INE1 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
