{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Inka1 functions as a potent endogenous regulator of p21‐activated kinase 4 (PAK4), acting as an inhibitor by directly binding to its catalytic domain. Structural studies in mammalian cells have revealed that Inka1 engages PAK4 with high affinity to block its kinase activity, providing a molecular tool for controlled inhibition of PAK4 signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In developmental contexts, Inka1 is expressed in neural crest cells and their derivatives where it contributes to craniofacial morphogenesis. Although its expression domain appears to be conserved among vertebrates, the regulatory mechanisms and specific developmental roles of Inka1 can vary between species."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Furthermore, as a known regulator of actin cytoskeleton remodeling, Inka1 is implicated in controlling cell migration and differentiation during neural development, underscoring its importance in modulating cytoskeletal dynamics via inhibition of PAK4."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yohendran Baskaran, Khay C Ang, Praju V Anekal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms9681"}], "href": "https://doi.org/10.1038/ncomms9681"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26607847"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26607847"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Bethany S Reid, Thomas D Sargent, Trevor Williams "}, {"type": "b", "children": [{"type": "t", "text": "Generation and characterization of a novel neural crest marker allele, Inka1-LacZ, reveals a role for Inka1 in mouse neural tube closure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Dyn (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/dvdy.22248"}], "href": "https://doi.org/10.1002/dvdy.22248"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20175189"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20175189"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yumi Iwasaki, Takahito Yumoto, Shin-Ichi Sakakibara "}, {"type": "b", "children": [{"type": "t", "text": "Expression profiles of inka2 in the murine nervous system."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene Expr Patterns (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gep.2015.08.002"}], "href": "https://doi.org/10.1016/j.gep.2015.08.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26292052"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26292052"}]}]}]}