{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n After reviewing the provided scientific abstracts, there is no mention or data on the gene “INSYN2B.” None of the studies (see"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "9"}]}, {"type": "t", "text": "—discussed its function. Instead, these abstracts focus on other genes and proteins involved in diverse biological \n processes and pathologies, such as:\n "}]}, {"type": "t", "text": "\n <ul>\n <li>\n Epigenetic biomarkers in breast cancer (e.g., hypermethylation of the DOK7 promoter) that may aid in early diagnosis \n (1).\n </li>\n <li>\n Genes regulated by the transcription factor Lmx1b during limb dorsalization, impacting skeletal formation (2).\n </li>\n <li>\n Novel markers of ovarian differentiation during fetal development (3).\n </li>\n <li>\n Genomic regions and candidate genes influencing the fatty acid profile in beef, with implications for human health \n (4).\n </li>\n <li>\n Genetic loci related to the risk of placental abruption, highlighting diverse functional pathways including endocrine \n and cardiovascular systems (5).\n </li>\n <li>\n Oncogenic roles of FAM196B in lung adenocarcinoma, as well as in other cancers such as esophageal and gastric cancer, \n where it supports cell proliferation through pathways like AKT signaling (6, 8, 9).\n </li>\n <li>\n The involvement of RMP in esophageal cancer progression and resistance to radiotherapy (7).\n </li>\n </ul>\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, while these abstracts provide valuable insights into potential biomarkers and mechanistic underpinnings of \n various diseases, none of them address the function or pathological role of INSYN2B. Therefore, based on the current \n literature provided, no conclusions regarding INSYN2B can be drawn.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Holger Heyn, F Javier Carmona, Antonio Gomez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DNA methylation profiling in breast cancer discordant identical twins identifies DOK7 as novel epigenetic biomarker."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgs321"}], "href": "https://doi.org/10.1093/carcin/bgs321"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23054610"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23054610"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jennifer M Feenstra, Kohei Kanaya, Charmaine U Pira, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Detection of genes regulated by Lmx1b during limb dorsalization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Growth Differ (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1440-169X.2012.01331.x"}], "href": "https://doi.org/10.1111/j.1440-169X.2012.01331.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22417325"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22417325"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Huijun Chen, James S Palmer, Rathi D Thiagarajan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of novel markers of mouse fetal ovary development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0041683"}], "href": "https://doi.org/10.1371/journal.pone.0041683"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22844512"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22844512"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Marcos V A Lemos, Hermenegildo Lucas Justino Chiaia, Mariana Piatto Berton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association between single nucleotide polymorphisms with beef fatty acid profile in Nellore cattle using the single step procedure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Genomics (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12864-016-2511-y"}], "href": "https://doi.org/10.1186/s12864-016-2511-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26960694"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26960694"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Tsegaselassie Workalemahu, Daniel A Enquobahrie, Bizu Gelaye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic variations and risk of placental abruption: A genome-wide association study and meta-analysis of genome-wide association studies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Placenta (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.placenta.2018.04.008"}], "href": "https://doi.org/10.1016/j.placenta.2018.04.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29884306"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29884306"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yu Feng, Xing Tong, Biao Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effect of FAM196B in human lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cancer (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/jca.24907"}], "href": "https://doi.org/10.7150/jca.24907"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30026842"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30026842"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Shaomu Chen, Yu Feng, Biao Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RMP promotes the proliferation and radioresistance of esophageal carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cancer (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/jca.32680"}], "href": "https://doi.org/10.7150/jca.32680"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31333787"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31333787"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Haifeng Xia, Fang Hu, Liangbin Pan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FAM196B promotes proliferation and migration via regulating epithelial-mesenchymal transition in esophageal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biomark (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/CBM-203023"}], "href": "https://doi.org/10.3233/CBM-203023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33749638"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33749638"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "J Zhang, D D Tong, M Xue, et al. 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