{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n INTS14 is a core component of a distinct nucleic acid–binding sub‐module within the Integrator complex. In particular, INTS14, together with INTS10 and INTS13, forms an intertwined complex that displays a unique “chain interlink” architecture reminiscent of the Ku70–Ku80 DNA repair complex. This structural feature underlies its affinity for nucleic acids—with a marked preference for binding RNA hairpin structures—and suggests that the module plays a critical role in positioning the catalytic cleavage machinery near its RNA targets. Functionally, although this INTS10–INTS13–INTS14 module contributes in an accessory manner to the proper 3′‐end processing of spliceosomal small nuclear RNAs, its most pronounced impact is on promoting transcription termination following transcriptional pausing. Thus, INTS14 helps bridge the cleavage module to target transcripts, ensuring accurate termination and proper regulation of gene expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kevin Sabath, Melanie L Stäubli, Sabrina Marti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "INTS10-INTS13-INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-020-17232-2"}], "href": "https://doi.org/10.1038/s41467-020-17232-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32647223"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32647223"}]}]}]}